View Item 

Show simple item record

Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient
dc.contributor.authorBaang, JH
dc.contributor.authorSmith, C
dc.contributor.authorMirabelli, C
dc.contributor.authorValesano, AL
dc.contributor.authorManthei, DM
dc.contributor.authorBachman, MA
dc.contributor.authorWobus, CE
dc.contributor.authorAdams, M
dc.contributor.authorWasher, L
dc.contributor.authorMartin, ET
dc.contributor.authorLauring, AS
dc.coverage.spatialUnited States
dc.date.accessioned2022-08-26T19:25:20Z
dc.date.available2022-08-26T19:25:20Z
dc.date.issued2021-01-01
dc.identifier.issn0022-1899
dc.identifier.issn1537-6613
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/33089317
dc.identifier.urihttps://hdl.handle.net/2027.42/174139en
dc.description.abstractWe describe a case of chronic coronavirus disease 2019 (COVID-19) in a patient with lymphoma and associated B-cell immunodeficiency. Viral cultures and sequence analysis demonstrate ongoing replication of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for at least 119 days. The patient had 3 admissions related to COVID-19 over a 4-month period and was treated twice with remdesivir and convalescent plasma with resolution of symptoms. The patient's lack of seroconversion and prolonged course illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection. This case highlights challenges in managing immunocompromised hosts, who may act as persistent shedders and sources of transmission.
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectantibody
dc.subjectevolution
dc.subjectimmunocompromise
dc.subjectAdenosine Monophosphate
dc.subjectAlanine
dc.subjectAntibodies, Viral
dc.subjectCOVID-19
dc.subjectHospitalization
dc.subjectHumans
dc.subjectImmunity, Humoral
dc.subjectImmunocompromised Host
dc.subjectLymphoma, Mantle-Cell
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrimary Immunodeficiency Diseases
dc.subjectSARS-CoV-2
dc.subjectSeroconversion
dc.subjectVirus Replication
dc.titleProlonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient
dc.typeArticle
dc.identifier.pmid33089317
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/174139/2/Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient.pdf
dc.identifier.doi10.1093/infdis/jiaa666
dc.identifier.doihttps://dx.doi.org/10.7302/5870
dc.identifier.sourceJournal of Infectious Diseases
dc.description.versionPublished version
dc.date.updated2022-08-26T19:25:19Z
dc.identifier.orcid0000-0002-5925-4289
dc.identifier.orcid0000-0003-2507-6987
dc.identifier.orcid0000-0001-5286-0924
dc.identifier.orcid0000-0003-2906-8335
dc.description.filedescriptionDescription of Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient.pdf : Accepted version
dc.identifier.volume223
dc.identifier.issue1
dc.identifier.startpage23
dc.identifier.endpage27
dc.identifier.name-orcidBaang, JH; 0000-0002-5925-4289
dc.identifier.name-orcidSmith, C
dc.identifier.name-orcidMirabelli, C
dc.identifier.name-orcidValesano, AL
dc.identifier.name-orcidManthei, DM
dc.identifier.name-orcidBachman, MA; 0000-0003-2507-6987
dc.identifier.name-orcidWobus, CE; 0000-0001-5286-0924
dc.identifier.name-orcidAdams, M
dc.identifier.name-orcidWasher, L
dc.identifier.name-orcidMartin, ET
dc.identifier.name-orcidLauring, AS; 0000-0003-2906-8335
dc.working.doi10.7302/5870en
dc.owningcollnameInternal Medicine, Department of


Files in this item

Name:
Prolonged Severe Acute Respiratory ...
Size:
396.1KB
Format:
PDF
Description:
Accepted version
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.