Effects of Helicobacter pylori treatment on the incidences of autoimmune diseases and inflammatory bowel disease in patients with diabetes mellitus
dc.contributor.author | Sheu, NW | |
dc.contributor.author | Huang, SH | |
dc.contributor.author | Wu, DC | |
dc.contributor.author | Kao, JY | |
dc.contributor.author | Lin, KD | |
dc.contributor.editor | Yamaoka, Yoshio | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2022-09-06T18:18:44Z | |
dc.date.available | 2022-09-06T18:18:44Z | |
dc.date.issued | 2022-05-01 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/35604898 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/174673 | en |
dc.description.abstract | Background Helicobacter pylori infection is known to decrease the incidences of autoimmune diseases and inflammatory bowel disease(IBD). Our aim was investigating the effect of H. pylori treatment in diabetes mellitus(DM) patients. Methods Adults with newly-diagnosed H. pylori infection or peptic ulcer disease(PUD) within the general population and DM population were identified from the National Health Insurance Research Database of Taiwan from 2000–2010. 79,181 patients were assigned to the 3 groups: general population with PUD without H. pylori treatment(PUD-HPRx in general population), DM patients with PUD without H. pylori treatment(PUD-HPRx in DM), and DM patients with PUD who received H. pylori treatment(PUD+HPRx in DM). Results Higher incidences of autoimmune diseases and IBD were observed in the PUD+HPRx in DM group than in the PUD-HPRx in general population and PUD-HPRx in DM groups (autoimmune diseases = 5.14% vs 3.47% and 3.65%; IBD = 5.60% vs 3.17% and 3.25%; P<0.0001). A lower all-cause mortality was noted in the PUD+HPRx in DM group (HR: 0.937, P<0.001) than in the PUD-HPRx in DM group. Trends of a higher incidence of IBD and a lower mortality in younger patients in the PUD+HPRx in DM group compared with the PUD-HPRx in DM group were noted. Conclusions The results revealed that H. pylori treatment increased the incidences of autoimmune diseases and IBD and decreased the all-cause mortality in the DM group with PUD. The effect was more significant in younger patients. This finding assists in realizing the influence of H. pylori treatment in the DM population. | |
dc.format.medium | Electronic-eCollection | |
dc.language | eng | |
dc.publisher | Public Library of Science (PLoS) | |
dc.rights | Licence for published version: Creative Commons Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Adult | |
dc.subject | Autoimmune Diseases | |
dc.subject | Chronic Disease | |
dc.subject | Diabetes Mellitus | |
dc.subject | Helicobacter Infections | |
dc.subject | Helicobacter pylori | |
dc.subject | Humans | |
dc.subject | Incidence | |
dc.subject | Inflammatory Bowel Diseases | |
dc.title | Effects of Helicobacter pylori treatment on the incidences of autoimmune diseases and inflammatory bowel disease in patients with diabetes mellitus | |
dc.type | Article | |
dc.identifier.pmid | 35604898 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/174673/2/Effects of Helicobacter pylori treatment on the incidences of autoimmune diseases and inflammatory bowel disease in patients.pdf | |
dc.identifier.doi | 10.1371/journal.pone.0265323 | |
dc.identifier.doi | https://dx.doi.org/10.7302/6404 | |
dc.identifier.source | PLoS ONE | |
dc.description.version | Published version | |
dc.date.updated | 2022-09-06T18:18:41Z | |
dc.identifier.orcid | 0000-0003-1238-8324 | |
dc.identifier.volume | 17 | |
dc.identifier.issue | 5 May | |
dc.identifier.startpage | e0265323 | |
dc.identifier.name-orcid | Sheu, NW | |
dc.identifier.name-orcid | Huang, SH | |
dc.identifier.name-orcid | Wu, DC | |
dc.identifier.name-orcid | Kao, JY; 0000-0003-1238-8324 | |
dc.identifier.name-orcid | Lin, KD | |
dc.working.doi | 10.7302/6404 | en |
dc.owningcollname | Internal Medicine, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.