MDM2 Protein Degraders

Wang, shaomeng; Li, Yangbing; YANG, Jiuling; Aguilar, Angelo; Zhou, Bing; HU, Jiantao; Xu, Fuming; Rej, Rohan; Han, Xin

MDM2 Protein Degraders

dc.contributor.author	Wang, shaomeng
dc.contributor.author	Li, Yangbing
dc.contributor.author	YANG, Jiuling
dc.contributor.author	Aguilar, Angelo
dc.contributor.author	Zhou, Bing
dc.contributor.author	HU, Jiantao
dc.contributor.author	Xu, Fuming
dc.contributor.author	Rej, Rohan
dc.contributor.author	Han, Xin
dc.coverage.spatial	US
dc.date.accessioned	2022-09-17T01:56:46Z
dc.date.available	2022-09-17T01:56:46Z
dc.date.submitted	2016-04-01
dc.identifier.uri	https://hdl.handle.net/2027.42/174698
dc.description.abstract	Disclose non-peptide, small-molecule compounds that bind to human MDM2 protein and induce degradation of MDM2. Such compounds have the therapeutic potential for the treatment of human cancer, including both leukemia, lymphoma, breast, prostate, colon, lung, panceatic and other types of human cancers in which MDM2 plays a role. In addition to cancer treatment, small-molecule MDM2 degraders may also have an application for the treatment of other conditions, such as macular degeneration.
dc.title	MDM2 Protein Degraders
dc.type	Patent
dc.description.bitstreamurl	http://deepblue.lib.umich.edu/bitstream/2027.42/174698/2/79206568_1537160410.pdf
dc.identifier.doi	https://dx.doi.org/10.7302/6429
dc.date.updated	2022-09-17T01:56:42Z
dc.identifier.orcid	0000-0003-0904-9137
dc.identifier.name-orcid	Wang, shaomeng
dc.identifier.name-orcid	Li, Yangbing
dc.identifier.name-orcid	YANG, Jiuling
dc.identifier.name-orcid	Aguilar, Angelo
dc.identifier.name-orcid	Zhou, Bing
dc.identifier.name-orcid	HU, Jiantao
dc.identifier.name-orcid	Xu, Fuming
dc.identifier.name-orcid	Rej, Rohan; 0000-0003-0904-9137
dc.identifier.name-orcid	Han, Xin
dc.working.doi	10.7302/6429	en
dc.owningcollname	Internal Medicine, Department of

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