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Into the unknown: Diagnosing mysterious brain lesions

dc.contributor.authorKassab, Ihab
dc.contributor.authorIsada, Carlos
dc.contributor.authorAzar, Marwan M.
dc.contributor.authorSarsam, Nadine
dc.contributor.authorJiang, Min
dc.contributor.authorCamelo-Piragua, Sandra
dc.contributor.authorKaul, Daniel
dc.contributor.authorMalinis, Maricar
dc.date.accessioned2022-09-26T16:02:38Z
dc.date.available2023-09-26 12:02:36en
dc.date.available2022-09-26T16:02:38Z
dc.date.issued2022-08
dc.identifier.citationKassab, Ihab; Isada, Carlos; Azar, Marwan M.; Sarsam, Nadine; Jiang, Min; Camelo-Piragua, Sandra ; Kaul, Daniel; Malinis, Maricar (2022). "Into the unknown: Diagnosing mysterious brain lesions." Transplant Infectious Disease 24(4): n/a-n/a.
dc.identifier.issn1398-2273
dc.identifier.issn1399-3062
dc.identifier.urihttps://hdl.handle.net/2027.42/174791
dc.description.abstractIn this inaugural clinicopathological conference, the invited experts discussed the diagnostic approach to central nervous system infections in immunocompromised hosts. The case presented involved a pancreas- kidney transplant recipient with multiple brain abscesses caused by Bartonella henselae. CSF metagenomic next- generation sequencing played a significant role in the diagnosis. Bartonella henselae is a gram- negative zoonotic pathogen that causes cat- scratch disease, which can be transmitted to humans through cat bites or scratches. Symptoms can vary in severity, correlating with the patient’s immune status. Visceral organ involvement, ocular involvement, and neurological manifestations have been reported in immunocompromised patients, but brain abscesses are rare.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherBartonella henselae
dc.subject.otherbrain abscess
dc.subject.otherorgan transplant
dc.titleInto the unknown: Diagnosing mysterious brain lesions
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMicrobiology and Immunology
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/174791/1/tid13829.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/174791/2/tid13829_am.pdf
dc.identifier.doi10.1111/tid.13829
dc.identifier.sourceTransplant Infectious Disease
dc.identifier.citedreferenceDoern GV. Detection of selected fastidious bacteria. Clin Infect Dis. 2000; 30 ( 1 ): 166 - 173. https://doi.org/10.1086/313586
dc.identifier.citedreferenceBross JE, Gordon G. Nocardial meningitis: case reports and review. Rev Infect Dis. 1991; 13 ( 1 ): 160 - 165. https://doi.org/10.1093/clinids/12.5.160
dc.identifier.citedreferenceGelfand JM, Genrich G, Green AJ, Tihan T, Cree BA. Encephalitis of unclear origin diagnosed by brain biopsy: a diagnostic challenge. JAMA Neurol. 2015; 72 ( 1 ): 66 - 72. https://doi.org/10.1001/jamaneurol.2014.2376
dc.identifier.citedreferenceCailleaux M, Pilmis B, Mizrahi A, et al. Impact of a multiplex PCR assay (FilmArray(R)) on the management of patients with suspected central nervous system infections. Eur J Clin Microbiol Infect Dis. 2020; 39 ( 2 ): 293 - 297. https://doi.org/10.1007/s10096- 019- 03724- 7
dc.identifier.citedreferenceO’Halloran JA, Franklin A, Lainhart W, Burnham CA, Powderly W, Dubberke E. Pitfalls associated with the use of molecular diagnostic panels in the diagnosis of cryptococcal meningitis. Open Forum Infect Dis. 2017; 4 ( 4 ): ofx242. https://doi.org/10.1093/ofid/ofx242
dc.identifier.citedreferenceWalker M, Sheets J, Hamer D, O’Neal C. Performance of the Biofire FilmArray meningitis/encephalitis panel in cryptococcal meningitis diagnosis. Open Forum Infect Dis. 2018; 5 (Suppl 1): S599
dc.identifier.citedreferenceSimner PJ, Miller S, Carroll KC. Understanding the promises and hurdles of metagenomic next- generation sequencing as a diagnostic tool for infectious diseases. Clin Infect Dis. 2018; 66 ( 5 ): 778 - 788. https://doi.org/10.1093/cid/cix881
dc.identifier.citedreferenceWilson MR, Sample HA, Zorn KC, et al. Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis. N Engl J Med. 2019; 380 ( 24 ): 2327 - 2340. https://doi.org/10.1056/NEJMoa1803396
dc.identifier.citedreferenceSalzberg SL, Breitwieser FP, Kumar A, et al. Next- generation sequencing in neuropathologic diagnosis of infections of the nervous system. Neurol Neuroimmunol Neuroinflamm. 2016; 3 ( 4 ): e251. https://doi.org/10.1212/NXI.0000000000000251
dc.identifier.citedreferenceNiles DT, Wijetunge DSS, Palazzi DL, Singh IR, Revell PA. Plasma metagenomic next- generation sequencing assay for identifying pathogens: a retrospective review of test utilization in a large children’s hospital. J Clin Microbiol. 2020; 58 ( 11 ). https://doi.org/10.1128/JCM.00794- 20
dc.identifier.citedreferenceBritt RH, Enzmann DR, Yeager AS. Neuropathological and computerized tomographic findings in experimental brain abscess. J Neurosurg. 1981; 55 ( 4 ): 590 - 603. https://doi.org/10.3171/jns.1981.55.4.0590
dc.identifier.citedreferenceRamachandran PS, Wilson MR. Metagenomics for neurological infections - expanding our imagination. Nat Rev Neurol. 2020; 16 ( 10 ): 547 - 556. https://doi.org/10.1038/s41582- 020- 0374- y
dc.identifier.citedreferenceNelson CA, Saha S, Mead PS. Cat- scratch disease in the United States, 2005- 2013. Emerg Infect Dis. 2016; 22 ( 10 ): 1741 - 1746. https://doi.org/10.3201/eid2210.160115
dc.identifier.citedreferenceBatts S, Demers DM. Spectrum and treatment of cat- scratch disease. Pediatr Infect Dis J. 2004; 23 ( 12 ): 1161 - 1162.
dc.identifier.citedreferenceWindsor JJ. Cat- scratch disease: epidemiology, aetiology and treatment. Br J Biomed Sci. 2001; 58 ( 2 ): 101 - 110.
dc.identifier.citedreferenceBehjati S, Tarpey PS. What is next generation sequencing? Arch Dis Child Educ Pract Ed. 2013; 98 ( 6 ): 236 - 238. https://doi.org/10.1136/archdischild- 2013- 304340
dc.identifier.citedreferenceDeurenberg RH, Bathoorn E, Chlebowicz MA, et al. Application of next generation sequencing in clinical microbiology and infection prevention. J Biotechnol. 2017; 243: 16 - 24. https://doi.org/10.1016/j.jbiotec.2016.12.022
dc.identifier.citedreferenceDura- Trave T, Yoldi- Petri ME, Gallinas- Victoriano F, Lavilla- Oiz A, Bove- Guri M. Neuroretinitis caused by Bartonella henselae (cat- scratch disease) in a 13- year- old girl. Int J Pediatr. 2010; 2010: 763105. https://doi.org/10.1155/2010/763105
dc.identifier.citedreferencePappas G, Cascio A, Rodriguez- Morales AJ. The immunology of zoonotic infections. Clin Dev Immunol. 2012; 2012: 208508. https://doi.org/10.1155/2012/208508
dc.identifier.citedreferenceGalindo- Bocero J, Sanchez- Garcia S, Alvarez- Coronado M, Rozas- Reyes P. Parinaud’s oculoglandular syndrome: a case report. Arch Soc Esp Oftalmol. 2017; 92 ( 1 ): 37 - 39. https://doi.org/10.1016/j.oftal.2016.02.003
dc.identifier.citedreferenceOkaro U, Addisu A, Casanas B, Anderson B. Bartonella species, an emerging cause of blood- culture- negative endocarditis. Clin Microbiol Rev. 2017; 30 ( 3 ): 709 - 746. https://doi.org/10.1128/CMR.00013- 17
dc.identifier.citedreferenceAl- Matar MJ, Petty RE, Cabral DA, et al. Rheumatic manifestations of Bartonella infection in 2 children. J Rheumatol. 2002; 29 ( 1 ): 184 - 186.
dc.identifier.citedreferenceFan J, Ali H. Cat scratch disease causing encephalitis. Proc Bayl Univ Med Cent. 2020; 33 ( 3 ): 440 - 441. https://doi.org/10.1080/08998280.2020.1756141
dc.identifier.citedreferenceBreitschwerdt E, Sontakke S, Hopkins S. Neurological Manifestations of Bartonellosis in Immunocompetent Patients: A Composite of Reports From 2005- 2012. November 4, 2012 https://www.omicsonline.org/open- access/neurological- manifestations- of- bartonellosis- in- immunocompetent- patients- a- composite- of- reports- from- 2314- 7326- 3- 124.php?aid=15914
dc.identifier.citedreferenceMarra CM. Neurologic complications of Bartonella henselae infection. Curr Opin Neurol. 1995; 8 ( 3 ): 164 - 169. https://doi.org/10.1097/00019052- 199506000- 00002
dc.identifier.citedreferenceWheeler SW, Wolf SM, Steinberg EA. Cat- scratch encephalopathy. Neurology. 1997; 49 ( 3 ): 876 - 878. https://doi.org/10.1212/wnl.49.3.876
dc.identifier.citedreferenceChomel BB, Boulouis HJ, Maruyama S, Breitschwerdt EB >. Bartonella spp. in pets and effect on human health. Emerg Infect Dis. 2006; 12 ( 3 ): 389 - 394.
dc.identifier.citedreferenceWright AJ, Fishman JA. Central nervous system syndromes in solid organ transplant recipients. Clin Infect Dis. 2014; 59 ( 7 ): 1001 - 1011. https://doi.org/10.1093/cid/ciu428
dc.identifier.citedreferenceCastro I, Ruiz J, Tasias M, Montero M, Salavert M. Central nervous system infections in immunocompromised patients. Rev Esp Quimioter. 2018; 31 (suppl 1 ): 56 - 61.
dc.identifier.citedreferenceMoritani T, Capizzano A, Kirby P, Policeni B. Viral infections and white matter lesions. Radiol Clin North Am. 2014; 52 ( 2 ): 355 - 382. https://doi.org/10.1016/j.rcl.2013.11.001
dc.identifier.citedreferenceCDC. Reported Tuberculosis in the United States. 2018. https://www.cdc.gov/tb/statistics/reports/2018/national_data.htm. Accessed August 10, 2021.
dc.identifier.citedreferenceBourgi K, Fiske C, Sterling TR. Tuberculosis meningitis. Curr Infect Dis Rep. 2017; 19 ( 11 ): 39. https://doi.org/10.1007/s11908- 017- 0595- 4
dc.identifier.citedreferenceBottieau E, Noe A, Florence E, Colebunders R. Multiple tuberculous brain abscesses in an HIV- infected patient successfully treated with HAART and antituberculous treatment. Infection. 2003; 31 ( 2 ): 118 - 120. https://doi.org/10.1007/s15010- 002- 2121- 2
dc.identifier.citedreferenceQian X, Nguyen DT, Lyu J, Albers AE, Bi X, Graviss EA. Risk factors for extrapulmonary dissemination of tuberculosis and associated mortality during treatment for extrapulmonary tuberculosis. Emerg Microbes Infect. 2018; 7 ( 1 ): 102. https://doi.org/10.1038/s41426- 018- 0106- 1
dc.identifier.citedreferenceWoldeamanuel YW, Girma B. A 43- year systematic review and meta- analysis: case- fatality and risk of death among adults with tuberculous meningitis in Africa. J Neurol. 2014; 261 ( 5 ): 851 - 865. https://doi.org/10.1007/s00415- 013- 7060- 6
dc.identifier.citedreferenceSelby R, Ramirez CB, Singh R, et al. Brain abscess in solid organ transplant recipients receiving cyclosporine- based immunosuppression. Arch Surg. 1997; 132 ( 3 ): 304 - 310. https://doi.org/10.1001/archsurg.1997.01430270090019
dc.identifier.citedreferenceBaddley JW, Salzman D, Pappas PG. Fungal brain abscess in transplant recipients: epidemiologic, microbiologic, and clinical features. Clin Transpl. 2002; 16 ( 6 ): 419 - 424. https://doi.org/10.1034/j.1399- 0012.2002.02033.x
dc.identifier.citedreferenceCoussement J, Lebeaux D, van Delden C, et al. Nocardia infection in solid organ transplant recipients: a multicenter European case- control study. Clin Infect Dis. 2016; 63 ( 3 ): 338 - 345. https://doi.org/10.1093/cid/ciw241
dc.identifier.citedreferenceCoussement J, Lebeaux D, Rouzaud C, Lortholary O. Nocardia infections in solid organ and hematopoietic stem cell transplant recipients. Curr Opin Infect Dis. 2017; 30 ( 6 ): 545 - 551. https://doi.org/10.1097/QCO.0000000000000404
dc.identifier.citedreferenceRobert- Gangneux F, Meroni V, Dupont D, et al. Toxoplasmosis in transplant recipients, Europe, 2010- 2014. Emerg Infect Dis. 2018; 24 ( 8 ): 1497 - 1504. https://doi.org/10.3201/eid2408.180045
dc.identifier.citedreferenceRamanan P, Scherger S, Benamu E, et al. Toxoplasmosis in non- cardiac solid organ transplant recipients: a case series and review of literature. Transpl Infect Dis. 2020; 22 ( 1 ): e13218. https://doi.org/10.1111/tid.13218
dc.identifier.citedreferencePereira MR, Rana MM, American Society of Transplantation Infectious Diseases Community of Practice. Methicillin- resistant Staphylococcus aureus in solid organ transplantation - guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019; 33 ( 9 ): e13611. https://doi.org/10.1111/ctr.13611
dc.identifier.citedreferenceMuccio CF, Caranci F, D’Arco F, et al. Magnetic resonance features of pyogenic brain abscesses and differential diagnosis using morphological and functional imaging studies: a pictorial essay. J Neuroradiol. 2014; 41 ( 3 ): 153 - 167. https://doi.org/10.1016/j.neurad.2014.05.004
dc.identifier.citedreferenceSaini J, Gupta RK, Jain KK. Intracranial infections: key neuroimaging findings. Semin Roentgenol. 2014; 49 ( 1 ): 86 - 98. https://doi.org/10.1053/j.ro.2013.09.001
dc.identifier.citedreferenceKontzialis M, Zamora CA. Teaching NeuroImages: starry- sky appearance in Rocky Mountain spotted fever. Neurology. 2015; 85 ( 12 ): e93. https://doi.org/10.1212/WNL.0000000000001959
dc.identifier.citedreferenceMichigan Disease Surveillance System. Weekly Disease Report for the Week Ending August 7th 2021. https://www.michigan.gov/documents/mdch/Current_WSR_272689_7.pdf. Accessed August 10, 2021.
dc.identifier.citedreferencevan Veen KE, Brouwer MC, van der Ende A, van de Beek D. Bacterial meningitis in solid organ transplant recipients: a population- based prospective study. Transpl Infect Dis. 2016; 18 ( 5 ): 674 - 680. https://doi.org/10.1111/tid.12570
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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