Host-microbe interactions and outcomes in multiple myeloma and hematopoietic stem cell transplantation.
dc.contributor.author | Pianko, MJ | |
dc.contributor.author | Golob, JL | |
dc.coverage.spatial | Netherlands | |
dc.date.accessioned | 2022-09-26T20:26:00Z | |
dc.date.available | 2023-09-26 16:26:01 | en |
dc.date.issued | 2022-04-29 | |
dc.identifier.issn | 0167-7659 | |
dc.identifier.issn | 1573-7233 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/35488106 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/174855 | en |
dc.description.abstract | Microbiota are essential to normal immune development and there is growing recognition of its importance to human health and disease and deepening understanding of the complexity of host-microbe interactions in the human gut and other tissues. Commensal microbes not only can influence host immunity locally through impacts of bioactive microbial metabolites and direct interactions with epithelial cells and innate immune receptors but also can exert systemic immunomodulatory effects via impacts on host immune cells capable of trafficking beyond the gut. Emerging data suggest microbiota influence the development of multiple myeloma (MM), a malignancy of the immune system derived from immunoglobulin-producing bone marrow plasma cells, through the promotion of inflammation. Superior treatment outcomes for MM correlate with a higher abundance of commensal microbiota capable of influencing inflammatory responses through the production of butyrate. In patients with hematologic malignancies, higher levels of diversity of the gut microbiota correlate with superior outcomes after hematopoietic stem cell transplantation. Correlative data support the impact of commensal microbiota on survival, risk of infection, disease relapse, and graft-versus-host disease (GVHD) after transplant. In this review, we will discuss the current understanding of the role of host-microbe interactions and the inflammatory tumor microenvironment of multiple myeloma, discuss data describing the key role of microbiota in hematopoietic stem cell transplantation for treatment of hematologic malignancies, and highlight several possible concepts for interventions directed at the gut microbiota to influence treatment outcomes. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | Springer Nature | |
dc.subject | Butyrate | |
dc.subject | Hematopoietic stem cell transplantation | |
dc.subject | Microbiome | |
dc.subject | Microbiota | |
dc.subject | Multiple myeloma | |
dc.subject | Short-chain fatty acids | |
dc.subject | Graft vs Host Disease | |
dc.subject | Hematologic Neoplasms | |
dc.subject | Hematopoietic Stem Cell Transplantation | |
dc.subject | Host Microbial Interactions | |
dc.subject | Humans | |
dc.subject | Multiple Myeloma | |
dc.subject | Tumor Microenvironment | |
dc.title | Host-microbe interactions and outcomes in multiple myeloma and hematopoietic stem cell transplantation. | |
dc.type | Article | |
dc.identifier.pmid | 35488106 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/174855/2/s10555-022-10033-7.pdf | |
dc.identifier.doi | 10.1007/s10555-022-10033-7 | |
dc.identifier.doi | https://dx.doi.org/10.7302/6484 | |
dc.identifier.source | Cancer Metastasis Reviews | |
dc.description.version | Published version | |
dc.date.updated | 2022-09-26T20:25:57Z | |
dc.identifier.orcid | 0000-0001-9295-9750 | |
dc.identifier.orcid | 0000-0003-0009-5815 | |
dc.description.filedescription | Description of s10555-022-10033-7.pdf : Published version | |
dc.identifier.volume | e-Rx ahead of print | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 367 | |
dc.identifier.endpage | 382 | |
dc.identifier.name-orcid | Pianko, MJ; 0000-0001-9295-9750 | |
dc.identifier.name-orcid | Golob, JL; 0000-0003-0009-5815 | |
dc.working.doi | 10.7302/6484 | en |
dc.owningcollname | Internal Medicine, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.