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Development of the Nude Rabbit Model
dc.contributor.authorSong, J
dc.contributor.authorHoenerhoff, M
dc.contributor.authorYang, D
dc.contributor.authorYang, Y
dc.contributor.authorDeng, C
dc.contributor.authorWen, L
dc.contributor.authorMa, L
dc.contributor.authorPallas, B
dc.contributor.authorZhao, C
dc.contributor.authorKoike, Y
dc.contributor.authorKoike, T
dc.contributor.authorLester, P
dc.contributor.authorYang, B
dc.contributor.authorZhang, J
dc.contributor.authorChen, YE
dc.contributor.authorXu, J
dc.coverage.spatialUnited States
dc.date.accessioned2022-10-05T14:36:16Z
dc.date.available2022-10-05T14:36:16Z
dc.date.issued2021-03-09
dc.identifier.issn2213-6711
dc.identifier.issn2213-6711
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/33606990
dc.identifier.urihttps://hdl.handle.net/2027.42/174883en
dc.description.abstractCRISPR-Cas9-mediated gene knockout of FOXN1 in rabbits leads to the establishment of the nude rabbit (NuRabbit) colony, characterized by the nude and immunodeficient phenotypes. NuRabbits support iPSC teratoma assay and tissue-engineered blood vessel transplant. The larger size and longer lifespan of NuRabbits, compared with those of nude mice, offer unique application opportunities in regenerative medicine research.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier
dc.rightsLicence for published version: Creative Commons Attribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFOXN1
dc.subjectimmunodeficiency
dc.subjectnude rabbit
dc.subjectstem cell
dc.subjectxenotransplant
dc.subjectAnimals
dc.subjectAnimals, Genetically Modified
dc.subjectBlood Vessel Prosthesis
dc.subjectForkhead Transcription Factors
dc.subjectHumans
dc.subjectInduced Pluripotent Stem Cells
dc.subjectMice
dc.subjectMice, Nude
dc.subjectModels, Animal
dc.subjectMutation
dc.subjectRabbits
dc.subjectSevere Combined Immunodeficiency
dc.subjectT-Lymphocytes
dc.subjectTeratoma
dc.subjectTransplantation, Heterologous
dc.titleDevelopment of the Nude Rabbit Model
dc.typeArticle
dc.identifier.pmid33606990
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/174883/2/Development of the Nude Rabbit Model.pdf
dc.identifier.doi10.1016/j.stemcr.2021.01.010
dc.identifier.doihttps://dx.doi.org/10.7302/6512
dc.identifier.sourceStem Cell Reports
dc.description.versionPublished version
dc.date.updated2022-10-05T14:36:07Z
dc.identifier.orcid0000-0003-2449-8651
dc.identifier.orcid0000-0002-2158-9155
dc.identifier.orcid0000-0003-2357-7825
dc.identifier.volume16
dc.identifier.issue3
dc.identifier.startpage656
dc.identifier.endpage665
dc.identifier.name-orcidSong, J
dc.identifier.name-orcidHoenerhoff, M
dc.identifier.name-orcidYang, D; 0000-0003-2449-8651
dc.identifier.name-orcidYang, Y
dc.identifier.name-orcidDeng, C
dc.identifier.name-orcidWen, L
dc.identifier.name-orcidMa, L
dc.identifier.name-orcidPallas, B
dc.identifier.name-orcidZhao, C
dc.identifier.name-orcidKoike, Y
dc.identifier.name-orcidKoike, T
dc.identifier.name-orcidLester, P
dc.identifier.name-orcidYang, B; 0000-0002-2158-9155
dc.identifier.name-orcidZhang, J
dc.identifier.name-orcidChen, YE; 0000-0003-2357-7825
dc.identifier.name-orcidXu, J
dc.working.doi10.7302/6512en
dc.owningcollnameInternal Medicine, Department of


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Licence for published version: Creative Commons Attribution 4.0 International
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