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Genome engineering technologies in rabbits
dc.contributor.authorSong, J
dc.contributor.authorZhang, J
dc.contributor.authorXu, J
dc.contributor.authorGarcia-Barrio, M
dc.contributor.authorEugene Chen, Y
dc.contributor.authorYang, D
dc.coverage.spatialChina
dc.date.accessioned2022-10-05T14:52:33Z
dc.date.available2022-10-05T14:52:33Z
dc.date.issued2020-01-01
dc.identifier.issn1674-8301
dc.identifier.issn2352-4685
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/32934190
dc.identifier.urihttps://hdl.handle.net/2027.42/174896en
dc.description.abstractThe rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates. However, the technology for precise genome manipulations in rabbit has been stalled for decades, severely limiting its applications in biomedical research. Novel genome editing technologies, especially CRISPR/Cas9, have remarkably enhanced precise genome manipulation in rabbits, and shown their superiority and promise for generating rabbit models of human genetic diseases. In this review, we summarize the brief history of transgenic rabbit technology and the development of novel genome editing technologies in rabbits.
dc.format.mediumPrint
dc.languageeng
dc.publisherJournal of Biomedical Research
dc.rightsLicence for published version: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectbase editing
dc.subjectgene targeting
dc.subjectgenome editing
dc.subjectrabbit
dc.subjecttransgenic animal
dc.titleGenome engineering technologies in rabbits
dc.typeArticle
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/174896/2/Genome engineering technologies in rabbits.pdf
dc.identifier.doi10.7555/JBR.34.20190133
dc.identifier.doihttps://dx.doi.org/10.7302/6525
dc.identifier.sourceJournal of Biomedical Research
dc.description.versionPublished version
dc.date.updated2022-10-05T14:52:30Z
dc.identifier.orcid0000-0003-2449-8651
dc.identifier.volume34
dc.identifier.issue4
dc.identifier.startpage1
dc.identifier.endpage13
dc.identifier.name-orcidSong, J
dc.identifier.name-orcidZhang, J
dc.identifier.name-orcidXu, J
dc.identifier.name-orcidGarcia-Barrio, M
dc.identifier.name-orcidEugene Chen, Y
dc.identifier.name-orcidYang, D; 0000-0003-2449-8651
dc.working.doi10.7302/6525en
dc.owningcollnameInternal Medicine, Department of


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Licence for published version: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International

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