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Influence of epigenetics on periodontitis and peri-implantitis pathogenesis
dc.contributor.authorLarsson, Lena
dc.contributor.authorKavanagh, Nolan M.
dc.contributor.authorNguyen, Trang V. N.
dc.contributor.authorCastilho, Rogerio M.
dc.contributor.authorBerglundh, Tord
dc.contributor.authorGiannobile, William V.
dc.date.accessioned2022-10-05T15:54:23Z
dc.date.available2023-11-05 11:54:20en
dc.date.available2022-10-05T15:54:23Z
dc.date.issued2022-10
dc.identifier.citationLarsson, Lena; Kavanagh, Nolan M.; Nguyen, Trang V. N.; Castilho, Rogerio M.; Berglundh, Tord; Giannobile, William V. (2022). "Influence of epigenetics on periodontitis and peri-implantitis pathogenesis." Periodontology 2000 (1): 125-137.
dc.identifier.issn0906-6713
dc.identifier.issn1600-0757
dc.identifier.urihttps://hdl.handle.net/2027.42/174979
dc.description.abstractPeriodontitis is a disease characterized by tooth-associated microbial biofilms that drive chronic inflammation and destruction of periodontal-supporting tissues. In some individuals, disease progression can lead to tooth loss. A similar condition can occur around dental implants in the form of peri-implantitis. The immune response to bacterial challenges is not only influenced by genetic factors, but also by environmental factors. Epigenetics involves the study of gene function independent of changes to the DNA sequence and its associated proteins, and represents a critical link between genetic and environmental factors. Epigenetic modifications have been shown to contribute to the progression of several diseases, including chronic inflammatory diseases like periodontitis and peri-implantitis. This review aims to present the latest findings on epigenetic influences on periodontitis and to discuss potential mechanisms that may influence peri-implantitis, given the paucity of information currently available.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherbiomaterials, dental implants, disease pathogenesis, epigenetics, genetics, periodontal diseases
dc.titleInfluence of epigenetics on periodontitis and peri-implantitis pathogenesis
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/174979/1/prd12453.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/174979/2/prd12453_am.pdf
dc.identifier.doi10.1111/prd.12453
dc.identifier.sourcePeriodontology 2000
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