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Burden of early hospitalization after simultaneous liver–kidney transplantation: Results from the US Multicenter SLKT Consortium

dc.contributor.authorSharma, Pratima
dc.contributor.authorXie, Jiaheng
dc.contributor.authorWang, Leyi
dc.contributor.authorZhang, Min
dc.contributor.authorMagee, John
dc.contributor.authorAnswine, Adeline
dc.contributor.authorBarman, Pranab
dc.contributor.authorJo, Jennifer
dc.contributor.authorSinha, Jasmine
dc.contributor.authorSchluger, Aaron
dc.contributor.authorPerreault, Gabriel J.
dc.contributor.authorWalters, Kara E.
dc.contributor.authorCullaro, Giuseppe
dc.contributor.authorWong, Randi
dc.contributor.authorFilipek, Natalia
dc.contributor.authorBiggins, Scott W.
dc.contributor.authorLai, Jennifer C.
dc.contributor.authorVanWagner, Lisa B.
dc.contributor.authorVerna, Elizabeth C.
dc.contributor.authorPatel, Yuval A.
dc.date.accessioned2022-11-09T21:17:06Z
dc.date.available2023-12-09 16:17:05en
dc.date.available2022-11-09T21:17:06Z
dc.date.issued2022-11
dc.identifier.citationSharma, Pratima; Xie, Jiaheng; Wang, Leyi; Zhang, Min; Magee, John; Answine, Adeline; Barman, Pranab; Jo, Jennifer; Sinha, Jasmine; Schluger, Aaron; Perreault, Gabriel J.; Walters, Kara E.; Cullaro, Giuseppe; Wong, Randi; Filipek, Natalia; Biggins, Scott W.; Lai, Jennifer C.; VanWagner, Lisa B.; Verna, Elizabeth C.; Patel, Yuval A. (2022). "Burden of early hospitalization after simultaneous liver–kidney transplantation: Results from the US Multicenter SLKT Consortium." Liver Transplantation (11): 1756-1765.
dc.identifier.issn1527-6465
dc.identifier.issn1527-6473
dc.identifier.urihttps://hdl.handle.net/2027.42/175069
dc.description.abstractThe burden of early hospitalization (within 6 months) following simultaneous liver–kidney transplant (SLKT) is not known. We examined risk factors associated with early hospitalization after SLKT and their impact on patient mortality conditional on 6-month survival. We used data from the US Multicenter SLKT Consortium cohort study of all adult SLKT recipients between 2002 and 2017 who were discharged alive following SLKT. We used Poisson regression to model rates of early hospitalizations after SLKT. Cox regression was used to identify risk factors associated with mortality conditional on survival at 6 months after SLKT. Median age (N = 549) was 57.7 years (interquartile range [IQR], 50.6–63.9) with 63% males and 76% Whites; 33% had hepatitis C virus, 20% had non–alcohol-associated fatty liver disease, 23% alcohol-associated liver disease, and 24% other etiologies. Median body mass index (BMI) and Model for End-Stage Liver Disease–sodium scores were 27.2 kg/m2 (IQR, 23.6–32.2 kg/m2) and 28 (IQR, 23–34), respectively. Two-thirds of the cohort had at least one hospitalization within the first 6 months of SLKT. Age, race, hospitalization at SLKT, diabetes mellitus, BMI, and discharge to subacute rehabilitation (SAR) facility after SLKT were independently associated with a high incidence rate ratio of early hospitalization. Number of hospitalizations within the first 6 months did not affect conditional survival. Early hospitalizations after SLKT were very common but did not affect conditional survival. Although most of the risk factors for early hospitalization were nonmodifiable, discharge to SAR after initial SLKT was associated with a significantly higher incidence rate of early hospitalization. Efforts and resources should be focused on identifying SLKT recipients at high risk for early hospitalization to optimize their predischarge care, discharge planning, and long-term follow-up.
dc.publisherWiley Periodicals, Inc.
dc.titleBurden of early hospitalization after simultaneous liver–kidney transplantation: Results from the US Multicenter SLKT Consortium
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelSurgery and Anesthesiology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175069/1/lt26523_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175069/2/lt26523.pdf
dc.identifier.doi10.1002/lt.26523
dc.identifier.sourceLiver Transplantation
dc.identifier.citedreferenceEason JD, Gonwa TA, Davis CL, Sung RS, Gerber D, Bloom RD. Proceedings of consensus conference on simultaneous liver kidney transplantation (SLK). Am J Transplant. 2008; 8: 2243 – 51.
dc.identifier.citedreferenceHart A, Smith JM, Skeans MA, Gustafson SK, Wilk AR, Castro S, et al. OPTN/SRTR 2018 annual data report: kidney. Am J Transplant. 2020; 20 ( Suppl 1 ): 20 – 130.
dc.identifier.citedreferenceSharma P. Liver-kidney: indications, patient selection, and allocation policy. Clin Liver Dis (Hoboken). 2019; 13: 165 – 9.
dc.identifier.citedreferenceBari K, Sharma P. Optimizing the selection of patients for simultaneous liver-kidney transplant. Clin Liver Dis. 2021; 25: 89 – 102.
dc.identifier.citedreferenceLikhitsup A, Hassan A, Mellinger J, Askari F, Winder GS, Saeed N, et al. Impact of a prohibitive versus restrictive tobacco policy on liver transplant candidate outcomes. Liver Transpl. 2019; 25: 1165 – 76.
dc.identifier.citedreferenceCullaro G, Sharma P, Jo J, Rassiwala J, VanWagner LB, Wong R, et al. Temporal trends and evolving outcomes after simultaneous liver-kidney transplantation (SLKT): results from the US SLKT Consortium. Liver Transpl. 2021; 27: 1613 – 22.
dc.identifier.citedreferenceSharma P, Sui Z, Zhang M, Magee JC, Barman P, Patel Y, et al. Renal outcomes after simultaneous liver-kidney transplantation: results from the US multicenter simultaneous liver-kidney transplantation consortium. Liver Transpl. 2021; 27: 1144 – 53.
dc.identifier.citedreferenceBentley ST, Ortner NJ. 2020 U.S. organ and tissue transplants: cost estimates, discussion, and emerging issues. Milliman Res Rep. 2020. [cited 2021 Oct 10]. Available from: https://member.aanlcp.org/wp-content/uploads/2021/03/2020-US-organ-tissue-transplants.pdf
dc.identifier.citedreferenceMcAdams-Demarco MA, Grams ME, King E, Desai NM, Segev DL. Sequelae of early hospital readmission after kidney transplantation. Am J Transplant. 2014; 14: 397 – 403.
dc.identifier.citedreferenceBurra P, De Bona M. Quality of life following organ transplantation. Transpl Int. 2007; 20: 397 – 409.
dc.identifier.citedreferenceSharma P, Goodrich NP, Schaubel DE, Smith AR, Merion RM. National assessment of early hospitalization after liver transplantation: risk factors and association with patient survival. Liver Transpl. 2017; 23: 1143 – 52.
dc.identifier.citedreferenceAxon RN, Williams MV. Hospital readmission as an accountability measure. JAMA. 2011; 305: 504 – 5.
dc.identifier.citedreferenceCMS. Hospital readmissions reduction program; 2021. [cited 2022 Mar 31]. Available from: https://www.cms.gov/Medicare/Quality-Initiatives-Patient-Assessment-Instruments/Value-Based-Programs/HRRP/Hospital-Readmission-Reduction-Program
dc.identifier.citedreferenceVanWagner LB, Skaro AI. Program-specific reports: implications and impact on program behavior. Curr Opin Organ Transplant. 2013; 18: 210 – 5.
dc.identifier.citedreferenceLubetzky M, Yaffe H, Chen C, Ali H, Kayler LK. Early readmission after kidney transplantation: examination of discharge-level factors. Transplantation. 2016; 100: 1079 – 85.
dc.identifier.citedreferenceMcAdams-Demarco MA, Grams ME, Hall EC, Coresh J, Segev DL. Early hospital readmission after kidney transplantation: patient and center-level associations. Am J Transplant. 2012; 12: 3283 – 8.
dc.identifier.citedreferenceNadim MK, Sung RS, Davis CL, Andreoni KA, Biggins SW, Danovitch GM, et al. Simultaneous liver-kidney transplantation summit: current state and future directions. Am J Transplant. 2012; 12: 2901 – 8.
dc.identifier.citedreferenceSharma P, Goodrich NP, Schaubel DE, Guidinger MK, Merion RM. Patient-specific prediction of ESRD after liver transplantation. J Am Soc Nephrol. 2013; 24: 2045 – 52.
dc.identifier.citedreferenceRao PS, Schaubel DE, Guidinger MK, Andreoni KA, Wolfe RA, Merion RM, et al. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation. 2009; 88: 231 – 6.
dc.identifier.citedreferenceBuchanan P, Dzebisashvili N, Lentine KL, Axelrod DA, Schnitzler MA, Salvalaggio PR. Liver transplantation cost in the model for end-stage liver disease era: looking beyond the transplant admission. Liver Transpl. 2009; 15: 1270 – 7.
dc.identifier.citedreferencePereira AA, Bhattacharya R, Carithers R, Reyes J, Perkins J. Clinical factors predicting readmission after orthotopic liver transplantation. Liver Transpl. 2012; 18: 1037 – 45.
dc.identifier.citedreferenceShankar N, Marotta P, Wall W, Albasheer M, Hernandez-Alejandro R, Chandok N. Defining readmission risk factors for liver transplantation recipients. Gastroenterol Hepatol (N Y). 2011; 7: 585 – 90.
dc.identifier.citedreferenceYu J, Hosmer A, Parks T, Sonnenday CJ, Sharma P. Predictors of early hospitalization after deceased donor liver transplantation. Dig Dis Sci. 2015; 60: 3242 – 7.
dc.identifier.citedreferenceGunsar F, Raimondo ML, Jones S, Terreni N, Wong C, Patch D, et al. Nutritional status and prognosis in cirrhotic patients. Aliment Pharmacol Ther. 2006; 24: 563 – 72.
dc.identifier.citedreferenceKalafateli M, Mantzoukis K, Choi Yau Y, Mohammad AO, Arora S, Rodrigues S, et al. Malnutrition and sarcopenia predict post-liver transplantation outcomes independently of the model for end-stage liver disease score. J Cachexia Sarcopenia Muscle. 2017; 8: 113 – 21.
dc.identifier.citedreferenceShamseddeen H, Pike F, Ghabril M, Patidar KR, Desai AP, Nephew L, et al. Karnofsky performance status predicts outcomes in candidates for simultaneous liver-kidney transplant. Clin Transplant. 2021; 35: e14190.
dc.identifier.citedreferenceTaner T, Park WD, Stegall MD. Unique molecular changes in kidney allografts after simultaneous liver-kidney compared with solitary kidney transplantation. Kidney Int. 2017; 91: 1193 – 202.
dc.identifier.citedreferenceSharma P, Sun Y, Neal J, Erley J, Shen J, Tischer S, et al. Renal outcomes of liver transplantation recipients receiving standard immunosuppression and early renal sparing immunosuppression: a retrospective single center study. Transplant Direct. 2019; 5: e480.
dc.identifier.citedreferenceVanWagner LB, Lapin B, Skaro AI, Lloyd-Jones DM, Rinella ME. Impact of renal impairment on cardiovascular disease mortality after liver transplantation for nonalcoholic steatohepatitis cirrhosis. Liver Int. 2015; 35: 2575 – 83.
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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