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Recombinant human platelet-derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: A triple-blinded, randomized, placebo-controlled trial
dc.contributor.authorTavelli, Lorenzo
dc.contributor.authorBarootchi, Shayan
dc.contributor.authorRodriguez, Maria Vera
dc.contributor.authorMancini, Leonardo
dc.contributor.authorMajzoub, Jad
dc.contributor.authorTravan, Suncica
dc.contributor.authorSugai, Jim
dc.contributor.authorChan, Hsun-Liang
dc.contributor.authorKripfgans, Oliver
dc.contributor.authorWang, Hom-Lay
dc.contributor.authorGiannobile, William V.
dc.date.accessioned2022-11-09T21:18:48Z
dc.date.available2023-12-09 16:18:42en
dc.date.available2022-11-09T21:18:48Z
dc.date.issued2022-11
dc.identifier.citationTavelli, Lorenzo; Barootchi, Shayan; Rodriguez, Maria Vera; Mancini, Leonardo; Majzoub, Jad; Travan, Suncica; Sugai, Jim; Chan, Hsun-Liang ; Kripfgans, Oliver; Wang, Hom-Lay ; Giannobile, William V. (2022). "Recombinant human platelet- derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: A triple- blinded, randomized, placebo- controlled trial." Journal of Clinical Periodontology 49(11): 1169-1184.
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.urihttps://hdl.handle.net/2027.42/175101
dc.description.abstractAimTo evaluate the efficacy of recombinant human platelet-derived growth factor (rhPDGF)-BB combined with a cross-linked collagen matrix (CCM) for the treatment of multiple adjacent gingival recession type 1 defects (MAGRs) in combination with the coronally advanced flap (CAF).Materials and MethodsThirty patients were enrolled in this triple-blind, randomized, placebo-controlled trial and treated with either CAF + CCM + rhPDGF, or CAF + CCM + saline. The primary outcome was mean root coverage (mRC) at 6 months. Complete root coverage, gain in gingival thickness (GT), keratinized tissue width, volumetric and ultrasonographic changes, and patient-reported outcome measures were also assessed. Mixed-modelling regression analyses were used for statistical comparisons.ResultsAt 6 months, the mRC of the CCM + rhPDGF and CCM alone groups were 88.25% and 77.72%, respectively (p = .02). A significant gain in GT was consistently observed for both treatment arms, and more so for the patients receiving the matrix containing rhPDGF through time (0.51 vs. 0.80 mm, on average, p = .01). The rhPDGF + CCM treated patients presented greater volume gain, higher soft tissue thickness, and a superior aesthetic score.ConclusionrhPDGF enhances the clinical, volumetric, and aesthetic outcomes of MAGRs above the results achieved with CAF + CCM alone (ClinicalTrials.gov NCT04462237).
dc.publisherWiley Periodicals, Inc.
dc.publisherBlackwell Publishing Ltd
dc.subject.otherrandomized clinical trial
dc.subject.othercollagen matrix
dc.subject.othergingival recession
dc.subject.otherplatelet-derived growth factor
dc.subject.otherroot coverage
dc.titleRecombinant human platelet-derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: A triple-blinded, randomized, placebo-controlled trial
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175101/1/jcpe13706.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175101/2/jcpe13706-sup-0001-Supinfo.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175101/3/jcpe13706_am.pdf
dc.identifier.doi10.1111/jcpe.13706
dc.identifier.sourceJournal of Clinical Periodontology
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