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International controlled study of revascularization and outcomes following COVID-positive mechanical thrombectomy
dc.contributor.authorDmytriw, Adam A.
dc.contributor.authorGhozy, Sherief
dc.contributor.authorSweid, Ahmad
dc.contributor.authorPiotin, Michel
dc.contributor.authorBekelis, Kimon
dc.contributor.authorSourour, Nader
dc.contributor.authorRaz, Eytan
dc.contributor.authorVela-Duarte, Daniel
dc.contributor.authorLinfante, Italo
dc.contributor.authorDabus, Guilherme
dc.contributor.authorKole, Max
dc.contributor.authorMartínez-Galdámez, Mario
dc.contributor.authorNimjee, Shahid M.
dc.contributor.authorLopes, Demetrius K.
dc.contributor.authorHassan, Ameer E.
dc.contributor.authorKan, Peter
dc.contributor.authorGhorbani, Mohammad
dc.contributor.authorLevitt, Michael R.
dc.contributor.authorEscalard, Simon
dc.contributor.authorMissios, Symeon
dc.contributor.authorShapiro, Maksim
dc.contributor.authorClarençon, Fréderic
dc.contributor.authorElhorany, Mahmoud
dc.contributor.authorTahir, Rizwan A.
dc.contributor.authorYoussef, Patrick P.
dc.contributor.authorPandey, Aditya S.
dc.contributor.authorStarke, Robert M.
dc.contributor.authorEl Naamani, Kareem
dc.contributor.authorAbbas, Rawad
dc.contributor.authorMansour, Ossama Y.
dc.contributor.authorGalvan, Jorge
dc.contributor.authorBillingsley, Joshua T.
dc.contributor.authorMortazavi, Abolghasem
dc.contributor.authorWalker, Melanie
dc.contributor.authorDibas, Mahmoud
dc.contributor.authorSettecase, Fabio
dc.contributor.authorHeran, Manraj K. S.
dc.contributor.authorKuhn, Anna L.
dc.contributor.authorPuri, Ajit S.
dc.contributor.authorMenon, Bijoy K.
dc.contributor.authorSivakumar, Sanjeev
dc.contributor.authorMowla, Ashkan
dc.contributor.authorD’Amato, Salvatore
dc.contributor.authorZha, Alicia M.
dc.contributor.authorCooke, Daniel
dc.contributor.authorVranic, Justin E.
dc.contributor.authorRegenhardt, Robert W.
dc.contributor.authorRabinov, James D.
dc.contributor.authorStapleton, Christopher J.
dc.contributor.authorGoyal, Mayank
dc.contributor.authorWu, Hannah
dc.contributor.authorCohen, Jake
dc.contributor.authorTurkel-Parella, David
dc.contributor.authorXavier, Andrew
dc.contributor.authorWaqas, Muhammad
dc.contributor.authorTutino, Vincent
dc.contributor.authorSiddiqui, Adnan
dc.contributor.authorGupta, Gaurav
dc.contributor.authorNanda, Anil
dc.contributor.authorKhandelwal, Priyank
dc.contributor.authorTiu, Cristina
dc.contributor.authorPortela, Pere C.
dc.contributor.authorPerez de la Ossa, Natalia
dc.contributor.authorUrra, Xabier
dc.contributor.authorLera, Mercedes
dc.contributor.authorArenillas, Juan F.
dc.contributor.authorRibo, Marc
dc.contributor.authorRequena, Manuel
dc.contributor.authorPiano, Mariangela
dc.contributor.authorPero, Guglielmo
dc.contributor.authorSousa, Keith
dc.contributor.authorAl-Mufti, Fawaz
dc.contributor.authorHashim, Zafar
dc.contributor.authorNayak, Sanjeev
dc.contributor.authorRenieri, Leonardo
dc.contributor.authorDu, Rose
dc.contributor.authorAziz-Sultan, Mohamed A.
dc.contributor.authorLiebeskind, David
dc.contributor.authorNogueira, Raul G.
dc.contributor.authorAbdalkader, Mohamad
dc.contributor.authorNguyen, Thanh N.
dc.contributor.authorVigilante, Nicholas
dc.contributor.authorSiegler, James E.
dc.contributor.authorGrossberg, Jonathan A.
dc.contributor.authorSaad, Hassan
dc.contributor.authorGooch, Michael R.
dc.contributor.authorHerial, Nabeel A.
dc.contributor.authorRosenwasser, Robert H.
dc.contributor.authorTjoumakaris, Stavropoula
dc.contributor.authorPatel, Aman B.
dc.contributor.authorTiwari, Ambooj
dc.contributor.authorJabbour, Pascal
dc.date.accessioned2022-11-09T21:20:38Z
dc.date.available2023-12-09 16:20:37en
dc.date.available2022-11-09T21:20:38Z
dc.date.issued2022-11
dc.identifier.citationDmytriw, Adam A.; Ghozy, Sherief; Sweid, Ahmad; Piotin, Michel; Bekelis, Kimon; Sourour, Nader; Raz, Eytan; Vela-Duarte, Daniel ; Linfante, Italo; Dabus, Guilherme; Kole, Max; Martínez-Galdámez, Mario ; Nimjee, Shahid M.; Lopes, Demetrius K.; Hassan, Ameer E.; Kan, Peter; Ghorbani, Mohammad; Levitt, Michael R.; Escalard, Simon; Missios, Symeon; Shapiro, Maksim; Clarençon, Fréderic ; Elhorany, Mahmoud; Tahir, Rizwan A.; Youssef, Patrick P.; Pandey, Aditya S.; Starke, Robert M.; El Naamani, Kareem; Abbas, Rawad; Mansour, Ossama Y.; Galvan, Jorge; Billingsley, Joshua T.; Mortazavi, Abolghasem; Walker, Melanie; Dibas, Mahmoud; Settecase, Fabio; Heran, Manraj K. S.; Kuhn, Anna L.; Puri, Ajit S.; Menon, Bijoy K.; Sivakumar, Sanjeev; Mowla, Ashkan; D’Amato, Salvatore; Zha, Alicia M.; Cooke, Daniel; Vranic, Justin E.; Regenhardt, Robert W.; Rabinov, James D.; Stapleton, Christopher J.; Goyal, Mayank; Wu, Hannah; Cohen, Jake; Turkel-Parella, David ; Xavier, Andrew; Waqas, Muhammad; Tutino, Vincent; Siddiqui, Adnan; Gupta, Gaurav; Nanda, Anil; Khandelwal, Priyank; Tiu, Cristina; Portela, Pere C.; Perez de la Ossa, Natalia; Urra, Xabier; Lera, Mercedes; Arenillas, Juan F.; Ribo, Marc; Requena, Manuel; Piano, Mariangela; Pero, Guglielmo; Sousa, Keith; Al-Mufti, Fawaz ; Hashim, Zafar; Nayak, Sanjeev; Renieri, Leonardo; Du, Rose; Aziz-Sultan, Mohamed A. ; Liebeskind, David; Nogueira, Raul G.; Abdalkader, Mohamad; Nguyen, Thanh N.; Vigilante, Nicholas; Siegler, James E.; Grossberg, Jonathan A.; Saad, Hassan; Gooch, Michael R.; Herial, Nabeel A.; Rosenwasser, Robert H.; Tjoumakaris, Stavropoula; Patel, Aman B.; Tiwari, Ambooj; Jabbour, Pascal (2022). "International controlled study of revascularization and outcomes following COVID- positive mechanical thrombectomy." European Journal of Neurology (11): 3273-3287.
dc.identifier.issn1351-5101
dc.identifier.issn1468-1331
dc.identifier.urihttps://hdl.handle.net/2027.42/175135
dc.description.abstractBackground and purposePrevious studies suggest that mechanisms and outcomes in patients with COVID-19-associated stroke differ from those in patients with non-COVID-19-associated strokes, but there is limited comparative evidence focusing on these populations. The aim of this study, therefore, was to determine if a significant association exists between COVID-19 status with revascularization and functional outcomes following thrombectomy for large vessel occlusion (LVO), after adjustment for potential confounding factors.MethodsA cross-sectional, international multicenter retrospective study was conducted in consecutively admitted COVID-19 patients with concomitant acute LVO, compared to a control group without COVID-19. Data collected included age, gender, comorbidities, clinical characteristics, details of the involved vessels, procedural technique, and various outcomes. A multivariable-adjusted analysis was conducted.ResultsIn this cohort of 697 patients with acute LVO, 302 had COVID-19 while 395 patients did not. There was a significant difference (p < 0.001) in the mean age (in years) and gender of patients, with younger patients and more males in the COVID-19 group. In terms of favorable revascularization (modified Thrombolysis in Cerebral Infarction [mTICI] grade 3), COVID-19 was associated with lower odds of complete revascularization (odds ratio 0.33, 95% confidence interval [CI] 0.23–0.48; p < 0.001), which persisted on multivariable modeling with adjustment for other predictors (adjusted odds ratio 0.30, 95% CI 0.12–0.77; p = 0.012). Moreover, endovascular complications, in-hospital mortality, and length of hospital stay were significantly higher among COVID-19 patients (p < 0.001).ConclusionCOVID-19 was an independent predictor of incomplete revascularization and poor functional outcome in patients with stroke due to LVO. Furthermore, COVID-19 patients with LVO were more often younger and had higher morbidity/mortality rates.We conducted a cross-sectional, international multicenter retrospective study of consecutively admitted COVID-19 patients with concomitant acute LVO, compared to a control group without COVID-19. Our results shows that COVID-19 was an independent predictor of incomplete revascularization and poor functional outcome in patients with stroke due to LVO. In addition, COVID-19 patients with LVO were more often younger and suffered higher morbidity/mortality rates.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherstroke
dc.subject.othermortality
dc.subject.othermorbidity
dc.subject.otherlarge vessel occlusion
dc.subject.otherCOVID-19
dc.titleInternational controlled study of revascularization and outcomes following COVID-positive mechanical thrombectomy
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175135/1/ene15493_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175135/2/ene15493.pdf
dc.identifier.doi10.1111/ene.15493
dc.identifier.sourceEuropean Journal of Neurology
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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