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Limited time-specific and longitudinal effects of depressive and manic symptoms on cognition in bipolar spectrum disorders

dc.contributor.authorEaster, Rebecca E.
dc.contributor.authorRyan, Kelly A.
dc.contributor.authorEstabrook, Ryne
dc.contributor.authorMarshall, David F.
dc.contributor.authorMcInnis, Melvin G.
dc.contributor.authorLangenecker, Scott A.
dc.date.accessioned2022-11-09T21:20:41Z
dc.date.available2023-12-09 16:20:39en
dc.date.available2022-11-09T21:20:41Z
dc.date.issued2022-11
dc.identifier.citationEaster, Rebecca E.; Ryan, Kelly A.; Estabrook, Ryne; Marshall, David F.; McInnis, Melvin G.; Langenecker, Scott A. (2022). "Limited time-specific and longitudinal effects of depressive and manic symptoms on cognition in bipolar spectrum disorders." Acta Psychiatrica Scandinavica 146(5): 430-441.
dc.identifier.issn0001-690X
dc.identifier.issn1600-0447
dc.identifier.urihttps://hdl.handle.net/2027.42/175136
dc.description.abstractObjectivesPrevious research suggests that cognitive performance worsens during manic and depressed states in bipolar disorder (BD). However, studies have often relied upon between-subject, cross-sectional analyses and smaller sample sizes. The current study examined the relationship between mood symptoms and cognition in a within-subject, longitudinal study with a large sample.MethodsSeven hundred and seventy-three individuals with BD completed a neuropsychological battery and mood assessments at baseline and 1-year follow-up. The battery captured eight domains of cognition: fine motor dexterity, visual memory, auditory memory, emotion processing, and four aspects of executive functioning: verbal fluency and processing speed; conceptual reasoning and set shifting; processing speed with influence resolution; and inhibitory control. Structural equation modeling was conducted to examine the cross-sectional and longitudinal relationships between depressive symptoms, manic symptoms, and cognitive performance. Age and education were included as covariates. Eight models were run with the respective cognitive domains.ResultsBaseline mood positively predicted 1-year mood, and baseline cognition positively predicted 1-year cognition. Mood and cognition were generally not related for the eight cognitive domains. Baseline mania was predictive in one of eight baseline domains (conceptual reasoning and set shifting); baseline cognition predicted 1-year symptoms (inhibitory control—depression symptoms, visual memory—manic symptoms).ConclusionsIn a large community sample of patients with bipolar spectrum disorder, cognitive performance appears to be largely unrelated to depressive and manic symptoms, suggesting that cognitive dysfunction is stable in BD and is not dependent on mood state in BD. Future work could examine how treatment affects relationship between cognition and mood.Significant OutcomesCognitive dysfunction appears to be largely independent of mood symptoms in bipolar disorder.LimitationsThe sample was generally highly educated (M = 15.22), the majority of the subsample with elevated manic symptoms generally presented with concurrent depressive elevated symptoms, and the study did not stratify recruitment based on mood state.
dc.publisherWiley Periodicals, Inc.
dc.publisherNew Understanding
dc.subject.othermania
dc.subject.othercognition
dc.subject.otherdepression
dc.subject.otherbipolar disorder
dc.titleLimited time-specific and longitudinal effects of depressive and manic symptoms on cognition in bipolar spectrum disorders
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPsychiatry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175136/1/acps13436_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175136/2/acps13436.pdf
dc.identifier.doi10.1111/acps.13436
dc.identifier.sourceActa Psychiatrica Scandinavica
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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