A Macroscopic Model for Simulating the Mucociliary Clearance in a Bronchial Bifurcation: The Role of Surface Tension
dc.contributor.author | Manolidis, M | |
dc.contributor.author | Isabey, D | |
dc.contributor.author | Louis, B | |
dc.contributor.author | Grotberg, JB | |
dc.contributor.author | Filoche, M | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2022-12-01T21:13:00Z | |
dc.date.available | 2022-12-01T21:13:00Z | |
dc.date.issued | 2016-12-01 | |
dc.identifier.issn | 0148-0731 | |
dc.identifier.issn | 1528-8951 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/27551810 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/175169 | en |
dc.description.abstract | The mucociliary clearance in the bronchial tree is the main mechanism by which the lungs clear themselves of deposited particulate matter. In this work, a macroscopic model of the clearance mechanism is proposed. Lubrication theory is applied for thin films with both surface tension effects and a moving wall boundary. The flow field is computed by the use of a finite-volume scheme on an unstructured grid that replicates a bronchial bifurcation. The carina in bronchial bifurcations is of special interest because it is a location of increased deposition of inhaled particles. In this study, the mucus flow is computed for different values of the surface tension. It is found that a minimal surface tension is necessary for efficiently removing the mucus while maintaining the mucus film thickness at physiological levels. | |
dc.format.medium | ||
dc.language | eng | |
dc.publisher | ASME International | |
dc.relation.haspart | ARTN 121005 | |
dc.subject | Animals | |
dc.subject | Bronchi | |
dc.subject | Computer Simulation | |
dc.subject | Humans | |
dc.subject | Models, Biological | |
dc.subject | Models, Chemical | |
dc.subject | Mucociliary Clearance | |
dc.subject | Mucus | |
dc.subject | Surface Tension | |
dc.title | A Macroscopic Model for Simulating the Mucociliary Clearance in a Bronchial Bifurcation: The Role of Surface Tension | |
dc.type | Article | |
dc.identifier.pmid | 27551810 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/175169/2/Manolidis J Biomech Eng 2016.pdf | |
dc.identifier.doi | 10.1115/1.4034507 | |
dc.identifier.doi | https://dx.doi.org/10.7302/6629 | |
dc.identifier.source | Journal of Biomechanical Engineering | |
dc.description.version | Published version | |
dc.date.updated | 2022-12-01T21:12:59Z | |
dc.identifier.orcid | 0000-0001-7917-2451 | |
dc.identifier.volume | 138 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 121005 | |
dc.identifier.name-orcid | Manolidis, M | |
dc.identifier.name-orcid | Isabey, D | |
dc.identifier.name-orcid | Louis, B | |
dc.identifier.name-orcid | Grotberg, JB; 0000-0001-7917-2451 | |
dc.identifier.name-orcid | Filoche, M | |
dc.working.doi | 10.7302/6629 | en |
dc.owningcollname | Biomedical Engineering, Department of |
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