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Chemotherapy-induced peripheral neuropathy onset is associated with early risk of depression and anxiety in breast cancer survivors
dc.contributor.authorMcNeish, Brendan L.
dc.contributor.authorRichardson, James K.
dc.contributor.authorWhitney, Daniel G.
dc.date.accessioned2022-12-05T16:38:52Z
dc.date.available2023-12-05 11:38:51en
dc.date.available2022-12-05T16:38:52Z
dc.date.issued2022-11
dc.identifier.citationMcNeish, Brendan L.; Richardson, James K.; Whitney, Daniel G. (2022). "Chemotherapy-induced peripheral neuropathy onset is associated with early risk of depression and anxiety in breast cancer survivors." European Journal of Cancer Care 31(6): n/a-n/a.
dc.identifier.issn0961-5423
dc.identifier.issn1365-2354
dc.identifier.urihttps://hdl.handle.net/2027.42/175183
dc.description.abstractObjectiveThe objective was to assess for an association between chemotherapy-induced peripheral neuropathy (CIPN) onset and development of depression and anxiety in breast cancer (BrCa) survivors.MethodsA retrospective observational cohort was used and identified from Optum’s De-identified Clinformatics® Data Mart Database years 2012–2015. Three groups of women were derived based on BrCa and CIPN status: BrCa+/CIPN+ (n = 244), BrCa+/CIPN− (n = 8870), and BrCa−/CIPN− (n = 1,125,711). The ratio of the prevalence ratios (RPR) determined if the change in risk of depression and anxiety from the 12-month preindex period to postindex period I (0–6 months) and II (7–12 months) was different for BrCa+/CIPN+ compared to BrCa+/CIPN− and BrCa−/CIPN−.ResultsThe adjusted RPR for depression was significantly elevated for BrCa+/CIPN+ compared to BrCa+/CIPN− and BrCa−/CIPN− for postindex periods I (RPR = 1.35 [1.10,1.65] and 1.33 [1.08,1.63], respectively) and II (RPR = 1.53 [1.21,1.94] and 1.50 [1.17,1.93], respectively). The RPR for anxiety was significantly elevated for BrCa+/CIPN+ compared to BrCa+/CIPN− and BrCa−/CIPN− for postindex periods I (RPR = 1.37 [1.12,1.67] and 1.31 [1.06,1.61], respectively) and II (RPR = 1.41 [1.13,1.76] and 1.28 [1.02,1.62], respectively).ConclusionsAmong BrCa survivors, CIPN onset is associated with a subsequent increased 12-month risk of depression and anxiety. Depression and anxiety screening should be considered in BrCa+/CIPN+ survivors, particularly given their known impact on fall risk. The observed association between CIPN and an increased risk of depression and anxiety should be further studied in prospective studies.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherchemotherapy
dc.subject.otherquality of life
dc.subject.othersupportive care
dc.subject.otherpsychological
dc.subject.otherbreast cancer
dc.titleChemotherapy-induced peripheral neuropathy onset is associated with early risk of depression and anxiety in breast cancer survivors
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelHematology and Oncology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175183/1/ecc13648_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175183/2/ecc13648.pdf
dc.identifier.doi10.1111/ecc.13648
dc.identifier.sourceEuropean Journal of Cancer Care
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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