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The utility of dried blood spot measurement of bone turnover markers in biological anthropology
dc.contributor.authorDevlin, Maureen J.
dc.contributor.authorEick, Geeta N.
dc.contributor.authorSnodgrass, J. Josh
dc.date.accessioned2022-12-05T16:39:41Z
dc.date.available2023-12-05 11:39:40en
dc.date.available2022-12-05T16:39:41Z
dc.date.issued2022-11
dc.identifier.citationDevlin, Maureen J.; Eick, Geeta N.; Snodgrass, J. Josh (2022). "The utility of dried blood spot measurement of bone turnover markers in biological anthropology." American Journal of Human Biology 34(11): n/a-n/a.
dc.identifier.issn1042-0533
dc.identifier.issn1520-6300
dc.identifier.urihttps://hdl.handle.net/2027.42/175199
dc.description.abstractObjectivesBone is a dynamic organ under continual turnover influenced by life history stage, energy dynamics, diet, climate, and disease. Bone turnover data have enormous potential in biological anthropology for testing evolutionary and biocultural hypotheses, yet few studies have integrated these biomarkers. In the present article we systematically review the current availability, future viability, and applicability of measuring bone turnover markers (BTMs) in dried blood spot (DBS) samples obtained from finger prick whole blood.MethodsOur review considers clinical and public health relevance, biomarker stability in DBS, assay availability, and cost. We consider biomarkers of bone formation such as osteocalcin (bone matrix protein), PINP (N-terminal propeptide of type I collagen), and alkaline phosphatase (osteoblast enzyme), as well as biomarkers of bone resorption such as CTX (marker of collagen breakdown) and TRACP5b (tartrate-resistant acid phosphatase 5b; osteoclast enzyme).ResultsTwo BTMs have been validated for DBS: osteocalcin (formation) and TRACP5b (resorption). Prime candidates for future development are CTX and PINP, the formation and resorption markers used for clinical monitoring of response to osteoporosis treatment.ConclusionBTMs are a field-friendly technique for longitudinal monitoring of skeletal biology during growth, reproduction and aging, combining minimized risk to study participants with maximized ease of sample storage and transport. This combination allows new insights into the effects of energy availability, disease, and physical activity level on bone, and questions about bone gain and loss across life history and in response to environmental factors; these issues are important in human biology, paleoanthropology, bioarchaeology, and forensic anthropology.
dc.publisherJohn Wiley & Sons, Inc.
dc.titleThe utility of dried blood spot measurement of bone turnover markers in biological anthropology
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175199/1/ajhb23816.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175199/2/ajhb23816_am.pdf
dc.identifier.doi10.1002/ajhb.23816
dc.identifier.sourceAmerican Journal of Human Biology
dc.identifier.citedreferenceRuff, C. B., Holt, B., Niskanen, M., Sladek, V., Berner, M., Garofalo, E., Garvin, H. M., Hora, M., Junno, J.-A., Schuplerova, E., Vilkama, R., & Whittey, E. ( 2015 ). Gradual decline in mobility with the adoption of food production in Europe. Proceedings of the National Academy of Sciences of the United States of America, 112 ( 23 ), 7147 – 7152. https://doi.org/10.1073/pnas.1502932112
dc.identifier.citedreferenceThompson, D. D., & Gunness-Hey, M. ( 1981 ). Bone mineral-osteon analysis of Yupik-Inupiaq skeletons. American Journal of Physical Anthropology, 55 ( 1 ), 1 – 7. https://doi.org/10.1002/ajpa.1330550102
dc.identifier.citedreferenceUrlacher, S. S., Ellison, P. T., Sugiyama, L. S., Pontzer, H., Eick, G., Liebert, M. A., Cepon-Robins, T. J., Gildner, T. E., & Snodgrass, J. J. ( 2018 ). Tradeoffs between immune function and childhood growth among Amazonian forager-horticulturalists. Proceedings of the National Academy of Sciences of the United States of America, 115 ( 17 ), E3914 – E3921. https://doi.org/10.1073/pnas.1717522115
dc.identifier.citedreferencevan der Meulen, M. C., Jepsen, K. J., & Mikic, B. ( 2001 ). Understanding bone strength: Size isn’t everything. Bone, 29 ( 2 ), 101 – 104. https://doi.org/10.1016/s8756-3282(01)00491-4
dc.identifier.citedreferenceVasikaran, S. D., Cooper, C., Eastell, R., Griesmacher, A., Morris, H. A., Trenti, T., & Kanis, J. A. ( 2011 ). International osteoporosis foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis. Clinical Chemistry and Laboratory Medicine, 49 ( 8 ), 1271 – 1274. https://doi.org/10.1515/CCLM.2011.602
dc.identifier.citedreferenceVasikaran, S. D., Miura, M., Pikner, R., Bhattoa, H. P., Cavalier, E., & IOF-IFCC Joint Committee on Bone Metabolism (C-BM). ( 2021 ). Practical considerations for the clinical application of Bone turnover markers in osteoporosis. Calcified Tissue International. https://doi.org/10.1007/s00223-021-00930-4
dc.identifier.citedreferenceViner, R., White, B., & Christie, D. ( 2017 ). Type 2 diabetes in adolescents: A severe phenotype posing major clinical challenges and public health burden. Lancet, 389 ( 10085 ), 2252 – 2260. https://doi.org/10.1016/S0140-6736(17)31371-5
dc.identifier.citedreferenceWallace, I. J., Demes, B., Mongle, C., Pearson, O. M., Polk, J. D., & Lieberman, D. E. ( 2014 ). Exercise-induced bone formation is poorly linked to local strain magnitude in the sheep tibia. PLoS One, 9 ( 6 ), e99108. https://doi.org/10.1371/journal.pone.0099108
dc.identifier.citedreferenceWallace, I. J., Felson, D. T., Worthington, S., Duryea, J., Clancy, M., Aliabadi, P., Eick, G. N., Snodgrass, J. J., Baggish, A. L., & Lieberman, D. E. ( 2019 ). Knee osteoarthritis risk in non-industrial societies undergoing an energy balance transition: Evidence from the indigenous Tarahumara of Mexico. Annals of the Rheumatic Diseases, 78 ( 12 ), 1693 – 1698. https://doi.org/10.1136/annrheumdis-2019-215886
dc.identifier.citedreferenceWallace, I. J., Kwaczala, A. T., Judex, S., Demes, B., & Carlson, K. J. ( 2013 ). Physical activity engendering loads from diverse directions augments the growing skeleton. Journal of Musculoskeletal & Neuronal Interactions, 13 ( 3 ), 283 – 288.
dc.identifier.citedreferenceWallace, I. J., Worthington, S., Felson, D. T., Jurmain, R. D., Wren, K. T., Maijanen, H., Woods, R. J., & Lieberman, D. E. ( 2017 ). Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proceedings of the National Academy of Sciences of the United States of America, 114 ( 35 ), 9332 – 9336. https://doi.org/10.1073/pnas.1703856114
dc.identifier.citedreferenceWeaver, C. M., & Peacock, M. ( 2019 ). Chapter 10—skeletal changes across the life span. In D. B. Burr & M. R. Allen (Eds.), Basic and applied Bone biology ( 2nd ed., pp. 189 – 202 ). Academic Press.
dc.identifier.citedreferenceWeihe, P., & Weihrauch-Bluher, S. ( 2019 ). Metabolic syndrome in children and adolescents: Diagnostic criteria, therapeutic options and perspectives. Current Obesity Reports, 8 ( 4 ), 472 – 479. https://doi.org/10.1007/s13679-019-00357-x
dc.identifier.citedreferenceWiley, A. S. ( 2021 ). Pearl lecture: Biological normalcy: A new framework for biocultural analysis of human population variation. American Journal of Human Biology, 33 ( 5 ), e23563. https://doi.org/10.1002/ajhb.23563
dc.identifier.citedreferenceWuster, C. ( 1993 ). Growth hormone and bone metabolism. Acta Endocrinologica, 128 ( Suppl 2 ), 14 – 18.
dc.identifier.citedreferenceYeung, S. S. Y., Reijnierse, E. M., Pham, V. K., Trappenburg, M. C., Lim, W. K., Meskers, C. G. M., & Maier, A. B. ( 2019 ). Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. Journal of Cachexia, Sarcopenia and Muscle, 10 ( 3 ), 485 – 500. https://doi.org/10.1002/jcsm.12411
dc.identifier.citedreferenceZebaze, R. M., Ghasem-Zadeh, A., Bohte, A., Iuliano-Burns, S., Mirams, M., Price, R. I., Mackie, E. J., & Seeman, E. ( 2010 ). Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: A cross-sectional study. Lancet, 375 ( 9727 ), 1729 – 1736. https://doi.org/10.1016/S0140-6736(10)60320-0
dc.identifier.citedreferenceZhou, H., Lu, S. S., & Dempster, D. W. ( 2010 ). Chapter 2—Bone remodeling: Cellular activities in Bone. In E. S. Orwoll, J. P. Bilezikian, & D. Vanderschueren (Eds.), Osteoporosis in men ( 2nd ed., pp. 15 – 24 ). Academic Press.
dc.identifier.citedreferenceAllen, M. R., & Burr, D. B. ( 2019 ). Chapter 5—Bone growth, modeling, and remodeling. In D. B. Burr & M. R. Allen (Eds.), Basic and applied Bone biology ( 2nd ed., pp. 85 – 100 ). Academic Press.
dc.identifier.citedreferenceAlswat, K. A. ( 2017 ). Gender Disparities in Osteoporosis. Journal of Clinical Medical Research, 9 ( 5 ), 382 – 387. https://doi.org/10.14740/jocmr2970w
dc.identifier.citedreferenceBailey, D. A. ( 1997 ). The Saskatchewan pediatric bone mineral accrual study: Bone mineral acquisition during the growing years. International Journal of Sports Medicine, 18 ( Suppl 3 ), S191 – S194.
dc.identifier.citedreferenceBarak, M. M., Lieberman, D. E., Raichlen, D., Pontzer, H., Warrener, A. G., & Hublin, J. J. ( 2013 ). Trabecular evidence for a human-like gait in Australopithecus africanus. PLoS One, 8 ( 11 ), e77687. https://doi.org/10.1371/journal.pone.0077687
dc.identifier.citedreferenceBerenbaum, F., Eymard, F., & Houard, X. ( 2013 ). Osteoarthritis, inflammation and obesity. Current Opinion in Rheumatology, 25 ( 1 ), 114 – 118. https://doi.org/10.1097/BOR.0b013e32835a9414
dc.identifier.citedreferenceBerenbaum, F., Wallace, I. J., Lieberman, D. E., & Felson, D. T. ( 2018 ). Modern-day environmental factors in the pathogenesis of osteoarthritis. Nature Reviews Rheumatology, 14 ( 11 ), 674 – 681. https://doi.org/10.1038/s41584-018-0073-x
dc.identifier.citedreferenceBilinski, W. J., Stefanska, A., Szternel, L., Bergmann, K., Siodmiak, J., Krintus, M., Paradowski, P. T., & Sypniewska, G. ( 2022 ). Relationships between bone turnover markers and factors associated with metabolic syndrome in prepubertal girls and boys. Nutrients, 14 ( 6 ), 1205. https://doi.org/10.3390/nu14061205
dc.identifier.citedreferenceBjornerem, A., Ghasem-Zadeh, A., Wang, X., Bui, M., Walker, S. P., Zebaze, R., & Seeman, E. ( 2017 ). Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding. Journal of Bone and Mineral Research, 32 ( 4 ), 681 – 687. https://doi.org/10.1002/jbmr.3018
dc.identifier.citedreferenceBonjour, J. P., Chevalley, T., Rizzoli, R., & Ferrari, S. ( 2007 ). Gene-environment interactions in the skeletal response to nutrition and exercise during growth. Medicine and Sport Science, 51, 64 – 80.
dc.identifier.citedreferenceBouxsein, M. L., & Seeman, E. ( 2009 ). Quantifying the material and structural determinants of bone strength. Best Practice & Research. Clinical Rheumatology, 23 ( 6 ), 741 – 753. https://doi.org/10.1016/j.berh.2009.09.008
dc.identifier.citedreferenceBrown, J. P., Albert, C., Nassar, B. A., Adachi, J. D., Cole, D., Davison, K. S., Dooley, K. C., Don-Wauchope, A., Douville, P., Hanley, D. A., Jamal, S. A., Josse, R., Kaiser, S., Krahn, J., Krause, R., Kremer, R., Lepage, R., Letendre, E., Morin, S., … Ste-Marie, L. G. ( 2009 ). Bone turnover markers in the management of postmenopausal osteoporosis. Clinical Biochemistry, 42 ( 10–11 ), 929 – 942. https://doi.org/10.1016/j.clinbiochem.2009.04.001
dc.identifier.citedreferenceBrown, J. P., Delmas, P. D., Malaval, L., Edouard, C., Chapuy, M. C., & Meunier, P. J. ( 1984 ). Serum bone Gla-protein: A specific marker for bone formation in postmenopausal osteoporosis. Lancet, 1 ( 8386 ), 1091 – 1093.
dc.identifier.citedreferenceBurr, D. B. ( 2019 ). Chapter 1—Bone morphology and organization. In D. B. Burr & M. R. Allen (Eds.), Basic and applied Bone biology ( 2nd ed., pp. 3 – 26 ). Academic Press.
dc.identifier.citedreferenceCavalier, E., Delanaye, P., & Moranne, O. ( 2013 ). Variability of new bone mineral metabolism markers in patients treated with maintenance hemodialysis: Implications for clinical decision making. American Journal of Kidney Diseases, 61 ( 5 ), 847 – 848. https://doi.org/10.1053/j.ajkd.2012.12.013
dc.identifier.citedreferenceChen, D., Shen, J., Zhao, W., Wang, T., Han, L., Hamilton, J. L., & Im, H. J. ( 2017 ). Osteoarthritis: Toward a comprehensive understanding of pathological mechanism. Bone Research, 5, 16044. https://doi.org/10.1038/boneres.2016.44
dc.identifier.citedreferenceChen, P., Satterwhite, J. H., Licata, A. A., Lewiecki, E. M., Sipos, A. A., Misurski, D. M., & Wagman, R. B. ( 2005 ). Early changes in biochemical markers of bone formation predict BMD response to teriparatide in postmenopausal women with osteoporosis. Journal of Bone and Mineral Research, 20 ( 6 ), 962 – 970. https://doi.org/10.1359/JBMR.050105
dc.identifier.citedreferenceChirchir, H., Kivell, T. L., Ruff, C. B., Hublin, J. J., Carlson, K. J., Zipfel, B., & Richmond, B. G. ( 2015 ). Recent origin of low trabecular bone density in modern humans. Proceedings of the National Academy of Sciences of the United States of America, 112 ( 2 ), 366 – 371. https://doi.org/10.1073/pnas.1411696112
dc.identifier.citedreferenceChoksi, P., Jepsen, K. J., & Clines, G. A. ( 2018 ). The challenges of diagnosing osteoporosis and the limitations of currently available tools. Clinical Diabetes and Endocrinology, 4, 12. https://doi.org/10.1186/s40842-018-0062-7
dc.identifier.citedreferenceChristensen, G. L., Halgreen, J. R., Milenkovski, M., Kose, A., Quardon, N., & Jorgensen, N. R. ( 2019 ). Bone turnover markers are differentially affected by pre-analytical handling. Osteoporosis International, 30 ( 5 ), 1137 – 1141. https://doi.org/10.1007/s00198-019-04837-7
dc.identifier.citedreferenceCisternas, M. G., Murphy, L., Sacks, J. J., Solomon, D. H., Pasta, D. J., & Helmick, C. G. ( 2016 ). Alternative methods for defining osteoarthritis and the impact on estimating prevalence in a US population-based survey. Arthritis Care & Research (Hoboken), 68 ( 5 ), 574 – 580. https://doi.org/10.1002/acr.22721
dc.identifier.citedreferenceClarke, B. ( 2008 ). Normal bone anatomy and physiology. Clinical Journal of the American Society of Nephrology, 3 ( Suppl 3 ), S131 – S139. https://doi.org/10.2215/CJN.04151206
dc.identifier.citedreferenceClowes, J. A., Hannon, R. A., Yap, T. S., Hoyle, N. R., Blumsohn, A., & Eastell, R. ( 2002 ). Effect of feeding on bone turnover markers and its impact on biological variability of measurements. Bone, 30 ( 6 ), 886 – 890. https://doi.org/10.1016/s8756-3282(02)00728-7
dc.identifier.citedreferenceCooper, D. M. L., Thomas, C. D. L., Clement, J. G., Turinsky, A. L., Sensen, C. W., & Hallgrímsson, B. ( 2007 ). Age-dependent change in the 3D structure of cortical porosity at the human femoral midshaft. Bone, 40 ( 4 ), 957 – 965. https://doi.org/10.1016/j.bone.2006.11.011
dc.identifier.citedreferenceCrandall, C. J., Tseng, C. H., Karlamangla, A. S., Finkelstein, J. S., Randolph, J. F., Jr., Thurston, R. C., Huang, M.-H., Zheng, H., & Greendale, G. A. ( 2013 ). Serum sex steroid levels and longitudinal changes in bone density in relation to the final menstrual period. The Journal of Clinical Endocrinology and Metabolism, 98 ( 4 ), E654 – E663. https://doi.org/10.1210/jc.2012-3651
dc.identifier.citedreferenceCurrey, J. D. ( 2002 ). Bones: Structure and mechanics. Princeton University Press.
dc.identifier.citedreferenceDelmas, P. D., Eastell, R., Garnero, P., Seibel, M. J., & Stepan, J. ( 2000 ). The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the international osteoporosis foundation. Osteoporosis International, 11 ( Suppl 6 ), S2 – S17.
dc.identifier.citedreferenceDelmas, P. D., Eastell, R., Garnero, P., Seibel, M. J., Stepan, J., & Committee of Scientific Advisors of the International Osteoporosis Foundation. ( 2000 ). The use of biochemical markers of bone turnover in osteoporosis. Osteoporosis International, 11 ( Suppl 6 ), S2 – S17. https://doi.org/10.1007/s001980070002
dc.identifier.citedreferenceDevlin, M. J., Van Vliet, M., Motyl, K., Karim, L., Brooks, D. J., Louis, L., Conlon, C., Rosen, C. J., & Bouxsein, M. L. ( 2014 ). Early-onset type 2 diabetes impairs skeletal acquisition in the male TALLYHO/JngJ mouse. Endocrinology, 155 ( 10 ), 3806 – 3816. https://doi.org/10.1210/en.2014-1041
dc.identifier.citedreferenceDiemar, S. S., Mollehave, L. T., Quardon, N., Lylloff, L., Thuesen, B. H., Linneberg, A., & Jorgensen, N. R. ( 2020 ). Effects of age and sex on osteocalcin and bone-specific alkaline phosphatase-reference intervals and confounders for two bone formation markers. Archives of Osteoporosis, 15 ( 1 ), 26. https://doi.org/10.1007/s11657-020-00715-6
dc.identifier.citedreferenceEick, G. N., Devlin, M. J., Cepon-Robins, T. J., Kowal, P., Sugiyama, L. S., & Snodgrass, J. J. ( 2019 ). A dried blood spot-based method to measure levels of tartrate-resistant acid phosphatase 5b (TRACP-5b), a marker of bone resorption. American Journal of Human Biology, 31 ( 3 ), e23240. https://doi.org/10.1002/ajhb.23240
dc.identifier.citedreferenceEick, G. N., Madimenos, F. C., Cepon-Robins, T. J., Devlin, M. J., Kowal, P., Sugiyama, L. S., & Snodgrass, J. J. ( 2020 ). Validation of an enzyme-linked immunoassay assay for osteocalcin, a marker of bone formation, in dried blood spots. American Journal of Human Biology, 32 ( 5 ), e23394. https://doi.org/10.1002/ajhb.23394
dc.identifier.citedreferenceElhakeem, A., Heron, J., Tobias, J. H., & Lawlor, D. A. ( 2020 ). Physical activity throughout adolescence and peak hip strength in young adults. JAMA Network Open, 3 ( 8 ), e2013463. https://doi.org/10.1001/jamanetworkopen.2020.13463
dc.identifier.citedreferenceFarrugia, W., & Melick, R. A. ( 1986 ). Metabolism of osteocalcin. Calcified Tissue International, 39 ( 4 ), 234 – 238. https://doi.org/10.1007/BF02555210
dc.identifier.citedreferenceFrost, H. M., Vilanueva, A. R., Jett, S., & Eyring, E. ( 1969 ). Tetracycline-based analysis of bone remodelling in osteopetrosis. Clinical Orthopaedics and Related Research, 65, 203 – 217.
dc.identifier.citedreferenceGarcia, A. R., Blackwell, A. D., Trumble, B. C., Stieglitz, J., Kaplan, H., & Gurven, M. D. ( 2020 ). Evidence for height and immune function trade-offs among preadolescents in a high pathogen population. Evolution, Medicine, and Public Health, 2020 ( 1 ), 86 – 99. https://doi.org/10.1093/emph/eoaa017
dc.identifier.citedreferenceGarnero, P., Grimaux, M., Seguin, P., & Delmas, P. D. ( 1994 ). Characterization of immunoreactive forms of human osteocalcin generated in vivo and in vitro. Journal of Bone and Mineral Research, 9 ( 2 ), 255 – 264. https://doi.org/10.1002/jbmr.5650090215
dc.identifier.citedreferenceGarnero, P., Sornay-Rendu, E., Claustrat, B., & Delmas, P. D. ( 2000 ). Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The OFELY study. Journal of Bone and Mineral Research, 15 ( 8 ), 1526 – 1536. https://doi.org/10.1359/jbmr.2000.15.8.1526
dc.identifier.citedreferenceGarnero, P., Vergnaud, P., & Hoyle, N. ( 2008 ). Evaluation of a fully automated serum assay for total N-terminal propeptide of type I collagen in postmenopausal osteoporosis. Clinical Chemistry, 54 ( 1 ), 188 – 196. https://doi.org/10.1373/clinchem.2007.094953
dc.identifier.citedreferenceGettler, L. T., McDade, T. W., Feranil, A. B., & Kuzawa, C. W. ( 2011 ). Longitudinal evidence that fatherhood decreases testosterone in human males. Proceedings of the National Academy of Sciences of the United States of America, 108 ( 39 ), 16194 – 16199. https://doi.org/10.1073/pnas.1105403108
dc.identifier.citedreferenceGillett, M. J., Vasikaran, S. D., & Inderjeeth, C. A. ( 2021 ). The role of PINP in diagnosis and management of metabolic bone disease. Clinical Biochemist Reviews, 42 ( 1 ), 3 – 10. https://doi.org/10.33176/AACB-20-0001
dc.identifier.citedreferenceGreenblatt, M. B., Tsai, J. N., & Wein, M. N. ( 2017 ). Bone turnover markers in the diagnosis and monitoring of metabolic bone disease. Clinical Chemistry, 63 ( 2 ), 464 – 474. https://doi.org/10.1373/clinchem.2016.259085
dc.identifier.citedreferenceGundberg, C. M., Looker, A. C., Nieman, S. D., & Calvo, M. S. ( 2002 ). Patterns of osteocalcin and bone specific alkaline phosphatase by age, gender, and race or ethnicity. Bone, 31 ( 6 ), 703 – 708. https://doi.org/10.1016/s8756-3282(02)00902-x
dc.identifier.citedreferenceGurven, M. D., & Lieberman, D. E. ( 2020 ). WEIRD bodies: Mismatch, medicine and missing diversity. Evolution and Human Behavior, 41 ( 5 ), 330 – 340. https://doi.org/10.1016/j.evolhumbehav.2020.04.001
dc.identifier.citedreferenceHalleen, J. M., Alatalo, S. L., Suominen, H., Cheng, S., Janckila, A. J., & Vaananen, H. K. ( 2000 ). Tartrate-resistant acid phosphatase 5b: A novel serum marker of bone resorption. Journal of Bone and Mineral Research, 15 ( 7 ), 1337 – 1345. https://doi.org/10.1359/jbmr.2000.15.7.1337
dc.identifier.citedreferenceHalleen, J. M., & Ranta, R. ( 2001 ). Tartrate-resistant acid phosphatase as a serum marker of bone resorption. American Clinical Laboratory, 20 ( 6 ), 29 – 30.
dc.identifier.citedreferenceHalleen, J. M., Ylipahkala, H., Alatalo, S. L., Janckila, A. J., Heikkinen, J. E., Suominen, H., Cheng, S., & Vaananen, H. K. ( 2002 ). Serum tartrate-resistant acid phosphatase 5b, but not 5a, correlates with other markers of bone turnover and bone mineral density. Calcified Tissue International, 71 ( 1 ), 20 – 25. https://doi.org/10.1007/s00223-001-2122-7
dc.identifier.citedreferenceHannemann, A., Friedrich, N., Spielhagen, C., Rettig, R., Ittermann, T., Nauck, M., & Wallaschofski, H. ( 2013 ). Reference intervals for serum osteocalcin concentrations in adult men and women from the study of health in Pomerania. BMC Endocrine Disorders, 13, 11. https://doi.org/10.1186/1472-6823-13-11
dc.identifier.citedreferenceHannon, R. A., Clowes, J. A., Eagleton, A. C., Al Hadari, A., Eastell, R., & Blumsohn, A. ( 2004 ). Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption. Bone, 34 ( 1 ), 187 – 194. https://doi.org/10.1016/j.bone.2003.04.002
dc.identifier.citedreferenceHarper, A. B., Laughlin, W. S., & Mazess, R. B. ( 1984 ). Bone mineral content in St Lawrence Island Eskimos. Human Biology, 56 ( 1 ), 63 – 78.
dc.identifier.citedreferenceHauschka, P. V., Lian, J. B., Cole, D. E., & Gundberg, C. M. ( 1989 ). Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiological Reviews, 69 ( 3 ), 990 – 1047.
dc.identifier.citedreferenceHenrich, J., Heine, S. J., & Norenzayan, A. ( 2010 ). The weirdest people in the world? The Behavioral and Brain Sciences, 33 ( 2-3 ), 61 – 83; discussion 83–135. https://doi.org/10.1017/S0140525X0999152X
dc.identifier.citedreferenceHill, T. R., McCarthy, D., Jakobsen, J., Lamberg-Allardt, C., Kiely, M., & Cashman, K. D. (2007). Seasonal changes in vitamin D status and bone turnover in healthy Irish postmenopausal women. International Journal for Vitamin and Nutrition Research, 77 (5), 320–325. https://doi.org/10.1024/0300-9831.77.5.320
dc.identifier.citedreferenceHirschfeld, H. P., Kinsella, R., & Duque, G. ( 2017 ). Osteosarcopenia: Where bone, muscle, and fat collide. Osteoporosis International, 28 ( 10 ), 2781 – 2790. https://doi.org/10.1007/s00198-017-4151-8
dc.identifier.citedreferenceJones, H., Priest, J., Hayes, W., Tichenor, C., & Nagel, D. ( 1977 ). Humeral hypertrophy in response to exercise. Journal of Bone and Joint Surgery [Am], 59, 204 – 208.
dc.identifier.citedreferenceKanis, J. A., Johnell, O., Oden, A., Sembo, I., Redlund-Johnell, I., Dawson, A., De Laet, C., & Jonsson, B. ( 2000 ). Long-term risk of osteoporotic fracture in Malmo. Osteoporosis International, 11 ( 8 ), 669 – 674.
dc.identifier.citedreferenceKannus, P., Haapasalo, H., Sankelo, M., Sievanen, H., Pasanen, M., Heinonen, A., Oja, P., & Vuori, I. ( 1995 ). Effect of starting age of physical activity on bone mass in the dominant arm of tennis and squash players. Annals of Internal Medicine, 123 ( 1 ), 27 – 31.
dc.identifier.citedreferenceKistler-Fischbacher, M., Weeks, B. K., & Beck, B. R. ( 2021a ). The effect of exercise intensity on bone in postmenopausal women (part 1): A systematic review. Bone, 143, 115696. https://doi.org/10.1016/j.bone.2020.115696
dc.identifier.citedreferenceKistler-Fischbacher, M., Weeks, B. K., & Beck, B. R. ( 2021b ). The effect of exercise intensity on bone in postmenopausal women (part 2): A meta-analysis. Bone, 143, 115697. https://doi.org/10.1016/j.bone.2020.115697
dc.identifier.citedreferenceKonda, N. N., Karri, R. S., Winnard, A., Nasser, M., Evetts, S., Boudreau, E., Caplan, N., Gradwell, D., & Velho, R. M. ( 2019 ). A comparison of exercise interventions from bed rest studies for the prevention of musculoskeletal loss. NPJ Microgravity, 5, 12. https://doi.org/10.1038/s41526-019-0073-4
dc.identifier.citedreferenceKovacs, C. S. ( 2016 ). Maternal mineral and bone metabolism during pregnancy, lactation, and post-weaning recovery. Physiological Reviews, 96 ( 2 ), 449 – 547. https://doi.org/10.1152/physrev.00027.2015
dc.identifier.citedreferenceKrez, A. N., & Stein, E. M. ( 2020 ). The skeletal consequences of bariatric surgery. Current Osteoporosis Reports, 18 ( 3 ), 262 – 272. https://doi.org/10.1007/s11914-020-00579-2
dc.identifier.citedreferenceKuzawa, C. W., Chugani, H. T., Grossman, L. I., Lipovich, L., Muzik, O., Hof, P. R., Wildman, D. E., Sherwood, C. C., Leonard, W. R., & Lange, N. ( 2014 ). Metabolic costs and evolutionary implications of human brain development. Proceedings of the National Academy of Sciences of the United States of America, 111 ( 36 ), 13010 – 13015. https://doi.org/10.1073/pnas.1323099111
dc.identifier.citedreferenceLascar, N., Brown, J., Pattison, H., Barnett, A. H., Bailey, C. J., & Bellary, S. ( 2018 ). Type 2 diabetes in adolescents and young adults. The Lancet Diabetes and Endocrinology, 6 ( 1 ), 69 – 80. https://doi.org/10.1016/S2213-8587(17)30186-9
dc.identifier.citedreferenceLawrence, R. C., Felson, D. T., Helmick, C. G., Arnold, L. M., Choi, H., Deyo, R. A., Gabriel, S., Hirsch, R., Hochberg, M. C., Hunder, G. G., Jordan, J. M., Katz, J. N., Kremers, H. M., Wolfe, F., & National Arthritis Data Workgroup. ( 2008 ). Estimates of the prevalence of arthritis and other rheumatic conditions in the United StatesPart II. Arthritis & Rheumatology, 58 ( 1 ), 26 – 35. https://doi.org/10.1002/art.23176
dc.identifier.citedreferenceLazenby, R. A. ( 1997 ). Bone loss, traditional diet, and cold adaptation in Arctic populations. American Journal of Human Biology, 9 ( 3 ), 329 – 341. https://doi.org/10.1002/(SICI)1520-6300(1997)9:3<329::AID-AJHB6>3.0.CO;2-T
dc.identifier.citedreferenceLee, A. J., Hodges, S., & Eastell, R. ( 2000 ). Measurement of osteocalcin. Annals of Clinical Biochemistry, 37 ( Pt 4 ), 432 – 446.
dc.identifier.citedreferenceLee, M. S., Kim, S. Y., Lee, M. C., Cho, B. Y., Lee, H. K., Koh, C. S., & Min, H. K. ( 1990 ). Negative correlation between the change in bone mineral density and serum osteocalcin in patients with hyperthyroidism. The Journal of Clinical Endocrinology and Metabolism, 70 ( 3 ), 766 – 770. https://doi.org/10.1210/jcem-70-3-766
dc.identifier.citedreferenceLeibson, C. L., Tosteson, A. N., Gabriel, S. E., Ransom, J. E., & Melton, L. J. ( 2002 ). Mortality, disability, and nursing home use for persons with and without hip fracture: A population-based study. Journal of the American Geriatrics Society, 50 ( 10 ), 1644 – 1650.
dc.identifier.citedreferenceLeonard, W. R., Levy, S. B., Tarskaia, L. A., Klimova, T. M., Fedorova, V. I., Baltakhinova, M. E., Krivoshapkin, V. G., & Snodgrass, J. J. ( 2014 ). Seasonal variation in basal metabolic rates among the Yakut (Sakha) of northeastern Siberia. American Journal of Human Biology, 26 ( 4 ), 437 – 445. https://doi.org/10.1002/ajhb.22524
dc.identifier.citedreferenceLevy, S. B., Klimova, T. M., Zakharova, R. N., Fedorov, A. I., Fedorova, V. I., Baltakhinova, M. E., Bondy, M., Atallah, D., Thompson-Vasquez, J., Dong, K., Debertine, A., & Leonard, W. R. ( 2022 ). Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates. American Journal of Human Biology, 34, e23723. https://doi.org/10.1002/ajhb.23723
dc.identifier.citedreferenceLieberman, D. E., Pearson, O. M., Polk, J. D., Demes, B., & Crompton, A. W. ( 2003 ). Optimization of bone growth and remodeling in response to loading in tapered mammalian limbs. The Journal of Experimental Biology, 206 ( Pt 18 ), 3125 – 3138.
dc.identifier.citedreferenceLockwood, C. A., Menter, C. G., Moggi-Cecchi, J., & Keyser, A. W. ( 2007 ). Extended male growth in a fossil hominin species. Science, 318 ( 5855 ), 1443 – 1446. https://doi.org/10.1126/science.1149211
dc.identifier.citedreferenceMacintosh, A. A., Davies, T. G., Pinhasi, R., & Stock, J. T. ( 2015 ). Declining tibial curvature parallels approximately 6150 years of decreasing mobility in central European agriculturalists. American Journal of Physical Anthropology, 157 ( 2 ), 260 – 275. https://doi.org/10.1002/ajpa.22710
dc.identifier.citedreferenceMacintosh, A. A., Pinhasi, R., & Stock, J. T. ( 2016 ). Early life conditions and physiological stress following the transition to farming in central/Southeast Europe: Skeletal growth impairment and 6000 years of gradual recovery. PLoS One, 11 ( 2 ), e0148468. https://doi.org/10.1371/journal.pone.0148468
dc.identifier.citedreferenceMacintosh, A. A., Pinhasi, R., & Stock, J. T. ( 2017 ). Prehistoric women’s manual labor exceeded that of athletes through the first 5500 years of farming in Central Europe. Science Advances, 3 ( 11 ), eaao3893. https://doi.org/10.1126/sciadv.aao3893
dc.identifier.citedreferenceMadimenos, F. C. ( 2015 ). An evolutionary and life-history perspective on osteoporosis. Annual Review of Anthropology, 44 ( 1 ), 189 – 206. https://doi.org/10.1146/annurev-anthro-102214-013954
dc.identifier.citedreferenceMadimenos, F. C., Liebert, M. A., Cepon-Robins, T. J., Snodgrass, J. J., & Sugiyama, L. S. ( 2015 ). Determining osteoporosis risk in older Colono adults from rural Amazonian Ecuador using calcaneal ultrasonometry. American Journal of Human Biology, 27 ( 1 ), 139 – 142. https://doi.org/10.1002/ajhb.22626
dc.identifier.citedreferenceMadimenos, F. C., Snodgrass, J. J., Blackwell, A. D., Liebert, M. A., Cepon, T. J., & Sugiyama, L. S. ( 2011 ). Normative calcaneal quantitative ultrasound data for the indigenous Shuar and non-Shuar Colonos of the Ecuadorian Amazon. Archives of Osteoporosis, 6, 39 – 49. https://doi.org/10.1007/s11657-011-0056-x
dc.identifier.citedreferenceMadimenos, F. C., Snodgrass, J. J., Liebert, M. A., Cepon, T. J., & Sugiyama, L. S. ( 2012 ). Reproductive effects on skeletal health in Shuar women of Amazonian Ecuador: A life history perspective. American Journal of Human Biology, 24 ( 6 ), 841 – 852. https://doi.org/10.1002/ajhb.22329
dc.identifier.citedreferenceManolagas, S. C. ( 2000 ). Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocrine Reviews, 21 ( 2 ), 115 – 137. https://doi.org/10.1210/edrv.21.2.0395
dc.identifier.citedreferenceMazess, R. B., & Mather, W. ( 1974 ). Bone mineral content of north Alaskan Eskimos. The American Journal of Clinical Nutrition, 27 ( 9 ), 916 – 925.
dc.identifier.citedreferenceMazess, R. B., & Mather, W. E. ( 1975 ). Bone mineral content in Canadian Eskimos. Human Biology, 47 ( 1 ), 44 – 63.
dc.identifier.citedreferenceMcDade, T. W., Williams, S., & Snodgrass, J. J. ( 2007 ). What a drop can do: Dried blood spots as a minimally invasive method for integrating biomarkers into population-based research. Demography, 44 ( 4 ), 899 – 925. https://doi.org/10.1353/dem.2007.0038
dc.identifier.citedreferenceMohammad Rahimi, G. R., Niyazi, A., & Alaee, S. ( 2021 ). The effect of exercise training on osteocalcin, adipocytokines, and insulin resistance: A systematic review and meta-analysis of randomized controlled trials. Osteoporosis International, 32 ( 2 ), 213 – 224. https://doi.org/10.1007/s00198-020-05592-w
dc.identifier.citedreferenceMotyl, K. J., Guntur, A. R., Carvalho, A. L., & Rosen, C. J. ( 2017 ). Energy Metabolism of Bone. Toxicologic Pathology, 45 ( 7 ), 887 – 893. https://doi.org/10.1177/0192623317737065
dc.identifier.citedreferenceMustafy, T., Londono, I., Moldovan, F., & Villemure, I. ( 2019 ). High impact exercise improves Bone microstructure and strength in growing rats. Scientific Reports, 9 ( 1 ), 13128. https://doi.org/10.1038/s41598-019-49432-2
dc.identifier.citedreferenceRuff, C. B., Trinkaus, E., Walker, A., & Larsen, C. S. ( 1993 ). Postcranial robusticity in homo. I: Temporal trends and mechanical interpretation. American Journal of Physical Anthropology, 91 ( 1 ), 21 – 53.
dc.identifier.citedreferenceNenonen, A., Cheng, S., Ivaska, K. K., Alatalo, S. L., Lehtimaki, T., Schmidt-Gayk, H., Uusi-Rasi, K., Heinonen, A., Kannus, P., Sievänen, H., Vuori, I., Väänänen, H. K., & Halleen, J. M. ( 2005 ). Serum TRACP 5b is a useful marker for monitoring alendronate treatment: Comparison with other markers of bone turnover. Journal of Bone and Mineral Research, 20 ( 10 ), 1804 – 1812. https://doi.org/10.1359/JBMR.050403
dc.identifier.citedreferenceNielsen, H. K., Brixen, K., & Mosekilde, L. ( 1990 ). Diurnal rhythm and 24-hour integrated concentrations of serum osteocalcin in normals: Influence of age, sex, season, and smoking habits. Calcified Tissue International, 47 ( 5 ), 284 – 290. https://doi.org/10.1007/BF02555910
dc.identifier.citedreferenceNikander, R., Kannus, P., Rantalainen, T., Uusi-Rasi, K., Heinonen, A., & Sievanen, H. ( 2010 ). Cross-sectional geometry of weight-bearing tibia in female athletes subjected to different exercise loadings. Osteoporosis International, 21 ( 10 ), 1687 – 1694. https://doi.org/10.1007/s00198-009-1101-0
dc.identifier.citedreferenceNikander, R., Sievanen, H., Heinonen, A., Daly, R. M., Uusi-Rasi, K., & Kannus, P. ( 2010 ). Targeted exercise against osteoporosis: A systematic review and meta-analysis for optimising bone strength throughout life. BMC Medicine, 8, 47. https://doi.org/10.1186/1741-7015-8-47
dc.identifier.citedreferenceOcobock, C., Soppela, P., Turunen, M., Stenback, V., Herzig, K. H., Rimbach, R., & Pontzer, H. ( 2022 ). Reindeer herders from subarctic Finland exhibit high total energy expenditure and low energy intake during the autumn herd roundup. American Journal of Human Biology, 34 ( 4 ), e23676. https://doi.org/10.1002/ajhb.23676
dc.identifier.citedreferencePaldanius, P. M., Ivaska, K. K., Makitie, O., & Viljakainen, H. ( 2021 ). Serum and urinary Osteocalcin in healthy 7- to 19-year-old Finnish children and adolescents. Frontiers in Pediatrics, 9, 610227. https://doi.org/10.3389/fped.2021.610227
dc.identifier.citedreferencePearson, O. M. ( 2000 ). Activity, climate, and postcranial robusticity: Implications for modern human origins and scenarios of adaptive change. Current Anthropology, 41 ( 4 ), 569 – 607.
dc.identifier.citedreferencePearson, O. M., & Lieberman, D. E. ( 2004 ). The aging of Wolff’s "law": Ontogeny and responses to mechanical loading in cortical bone. The American Journal of Physical Anthropology, 39, 63 – 99.
dc.identifier.citedreferencePollock, N. K., Bernard, P. J., Gutin, B., Davis, C. L., Zhu, H., & Dong, Y. ( 2011 ). Adolescent obesity, bone mass, and cardiometabolic risk factors. The Journal of Pediatrics, 158 ( 5 ), 727 – 734. https://doi.org/10.1016/j.jpeds.2010.11.052
dc.identifier.citedreferencePollock, N. K., Bernard, P. J., Wenger, K., Misra, S., Gower, B. A., Allison, J. D., Zhu, H., & Davis, C. L. ( 2010 ). Lower bone mass in prepubertal overweight children with prediabetes. Journal of Bone and Mineral Research, 25 ( 12 ), 2760 – 2769. https://doi.org/10.1002/jbmr.184
dc.identifier.citedreferencePontzer, H. ( 2018 ). Energy constraint as a novel mechanism linking exercise and health. Physiology (Bethesda), 33 ( 6 ), 384 – 393. https://doi.org/10.1152/physiol.00027.2018
dc.identifier.citedreferencePontzer, H., Durazo-Arvizu, R., Dugas, L. R., Plange-Rhule, J., Bovet, P., Forrester, T. E., Lambert, E. V., Cooper, R. S., Schoeller, D. A., & Luke, A. ( 2016 ). Constrained Total energy expenditure and metabolic adaptation to physical activity in adult humans. Current Biology, 26 ( 3 ), 410 – 417. https://doi.org/10.1016/j.cub.2015.12.046
dc.identifier.citedreferenceRaichlen, D. A., Gordon, A. D., Foster, A. D., Webber, J. T., Sukhdeo, S. M., Scott, R. S., Gosman, J. H., & Ryan, T. M. ( 2015 ). An ontogenetic framework linking locomotion and trabecular bone architecture with applications for reconstructing hominin life history. Journal of Human Evolution, 81, 1 – 12. https://doi.org/10.1016/j.jhevol.2015.01.003
dc.identifier.citedreferenceRauch, F., Travers, R., & Glorieux, F. H. ( 2007 ). Intracortical remodeling during human bone development: a histomorphometric study. Bone, 40 ( 2 ), 274 – 280. https://doi.org/10.1016/j.bone.2006.09.012
dc.identifier.citedreferenceRiddle, R. C., & Clemens, T. L. ( 2017 ). Bone cell bioenergetics and skeletal energy homeostasis. Physiological Reviews, 97 ( 2 ), 667 – 698. https://doi.org/10.1152/physrev.00022.2016
dc.identifier.citedreferenceRobling, A. G., Daly, R., Fuchs, R. K., & Burr, D. B. ( 2019 ). Chapter 11—mechanical adaptation. In D. B. Burr & M. R. Allen (Eds.), Basic and applied Bone biology ( 2nd ed., pp. 203 – 233 ). Academic Press.
dc.identifier.citedreferenceRobling, A. G., Hinant, F. M., Burr, D. B., & Turner, C. H. ( 2002 ). Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. Journal of Bone and Mineral Research, 17 ( 8 ), 1545 – 1554.
dc.identifier.citedreferenceRochira, V. ( 2020 ). Late-onset hypogonadism: Bone health. Andrology, 8 ( 6 ), 1539 – 1550. https://doi.org/10.1111/andr.12827
dc.identifier.citedreferenceRoss, P. D., & Knowlton, W. ( 1998 ). Rapid bone loss is associated with increased levels of biochemical markers. Journal of Bone and Mineral Research, 13 ( 2 ), 297 – 302. https://doi.org/10.1359/jbmr.1998.13.2.297
dc.identifier.citedreferenceRuff, C. B. ( 1994 ). Morphological adaptation to climate in modern and fossil hominids. American Journal of Physical Anthropology, 37 ( S19 ), 65 – 107. https://doi.org/10.1002/ajpa.1330370605
dc.identifier.citedreferenceRuff, C. B. ( 2005 ). Mechanical determinants of bone form: Insights from skeletal remains. Journal of Musculoskeletal & Neuronal Interactions, 5 ( 3 ), 202 – 212.
dc.identifier.citedreferenceRyan, T. M., & Shaw, C. N. ( 2015 ). Gracility of the modern Homo sapiens skeleton is the result of decreased biomechanical loading. Proceedings of the National Academy of Sciences of the United States of America, 112 ( 2 ), 372 – 377. https://doi.org/10.1073/pnas.1418646112
dc.identifier.citedreferenceSalhotra, A., Shah, H. N., Levi, B., & Longaker, M. T. ( 2020 ). Mechanisms of bone development and repair. Nature Reviews. Molecular Cell Biology, 21 ( 11 ), 696 – 711. https://doi.org/10.1038/s41580-020-00279-w
dc.identifier.citedreferenceSambrook, P., & Cooper, C. ( 2006 ). Osteoporosis. Lancet, 367 ( 9527 ), 2010 – 2018. https://doi.org/10.1016/S0140-6736(06)68891-0
dc.identifier.citedreferenceSchafer, A. L. ( 2016 ). Decline in bone mass during weight loss: A cause for concern? Journal of Bone and Mineral Research, 31 ( 1 ), 36 – 39. https://doi.org/10.1002/jbmr.2754
dc.identifier.citedreferenceScott, J. P., Sale, C., Greeves, J. P., Casey, A., Dutton, J., & Fraser, W. D. ( 2012 ). Effect of fasting versus feeding on the bone metabolic response to running. Bone, 51 ( 6 ), 990 – 999. https://doi.org/10.1016/j.bone.2012.08.128
dc.identifier.citedreferenceShanbhogue, V. V., Mitchell, D. M., Rosen, C. J., & Bouxsein, M. L. ( 2016 ). Type 2 diabetes and the skeleton: New insights into sweet bones. The Lancet Diabetes and Endocrinology, 4 ( 2 ), 159 – 173. https://doi.org/10.1016/S2213-8587(15)00283-1
dc.identifier.citedreferenceShaw, C. N., & Stock, J. T. ( 2013 ). Extreme mobility in the late Pleistocene? Comparing limb biomechanics among fossil homo, varsity athletes and Holocene foragers. Journal of Human Evolution, 64 ( 4 ), 242 – 249. https://doi.org/10.1016/j.jhevol.2013.01.004
dc.identifier.citedreferenceSiddiqui, J. A., & Partridge, N. C. ( 2016 ). Physiological Bone remodeling: Systemic regulation and growth factor involvement. Physiology (Bethesda), 31 ( 3 ), 233 – 245. https://doi.org/10.1152/physiol.00061.2014
dc.identifier.citedreferenceSinger, F. R., Bone, H. G., 3rd, Hosking, D. J., Lyles, K. W., Murad, M. H., Reid, I. R., Siris, E. S., & Endocrine Society. ( 2014 ). Paget’s disease of bone: An endocrine society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 99 ( 12 ), 4408 – 4422. https://doi.org/10.1210/jc.2014-2910
dc.identifier.citedreferenceSmith, C., Tacey, A., Mesinovic, J., Scott, D., Lin, X., Brennan-Speranza, T. C., Lewis, J. R., Duque, G., & Levinger, I. ( 2021 ). The effects of acute exercise on bone turnover markers in middle-aged and older adults: A systematic review. Bone, 143, 115766. https://doi.org/10.1016/j.bone.2020.115766
dc.identifier.citedreferenceSmith, C., Voisin, S., Al Saedi, A., Phu, S., Brennan-Speranza, T., Parker, L., Eynon, N., Hiam, D., Yan, X., Scott, D., Blekkenhorst, L. C., Lewis, J. R., Seeman, E., Byrnes, E., Flicker, L., Duque, G., Yeap, B. B., & Levinger, I. ( 2020 ). Osteocalcin and its forms across the lifespan in adult men. Bone, 130, 115085. https://doi.org/10.1016/j.bone.2019.115085
dc.identifier.citedreferenceSnodgrass, J. J., Leonard, W. R., Tarskaia, L. A., & Schoeller, D. A. ( 2006 ). Total energy expenditure in the Yakut (Sakha) of Siberia as measured by the doubly labeled water method. The American Journal of Clinical Nutrition, 84 ( 4 ), 798 – 806.
dc.identifier.citedreferenceStarup-Linde, J., Hygum, K., Harslof, T., & Langdahl, B. ( 2019 ). Type 1 diabetes and bone fragility: Links and risks. Diabetes, Metabolic Syndrome and Obesity, 12, 2539 – 2547. https://doi.org/10.2147/DMSO.S191091
dc.identifier.citedreferenceStarup-Linde, J., & Vestergaard, P. ( 2016 ). Biochemical bone turnover markers in diabetes mellitus - a systematic review. Bone, 82, 69 – 78. https://doi.org/10.1016/j.bone.2015.02.019
dc.identifier.citedreferenceStieglitz, J., Beheim, B. A., Trumble, B. C., Madimenos, F. C., Kaplan, H., & Gurven, M. ( 2015 ). Low mineral density of a weight-bearing bone among adult women in a high fertility population. American Journal of Physical Anthropology, 156 ( 4 ), 637 – 648. https://doi.org/10.1002/ajpa.22681
dc.identifier.citedreferenceStieglitz, J., Madimenos, F., Kaplan, H., & Gurven, M. ( 2016 ). Calcaneal quantitative ultrasound indicates reduced Bone status among physically active adult forager-horticulturalists. Journal of Bone and Mineral Research, 31 ( 3 ), 663 – 671. https://doi.org/10.1002/jbmr.2730
dc.identifier.citedreferenceSzulc, P. ( 2018 ). Bone turnover: Biology and assessment tools. Best Practice & Research. Clinical Endocrinology & Metabolism, 32 ( 5 ), 725 – 738. https://doi.org/10.1016/j.beem.2018.05.003
dc.identifier.citedreferenceSzulc, P., Naylor, K., Hoyle, N. R., Eastell, R., Leary, E. T., & National Bone Health Alliance Bone Turnover Marker P. ( 2017 ). Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability. Osteoporosis International, 28 ( 9 ), 2541 – 2556. https://doi.org/10.1007/s00198-017-4082-4
dc.identifier.citedreferenceSzulc, P., Seeman, E., & Delmas, P. D. ( 2000 ). Biochemical measurements of bone turnover in children and adolescents. Osteoporosis International, 11 ( 4 ), 281 – 294. https://doi.org/10.1007/s001980070116
dc.identifier.citedreferenceTang, S. J., Meikle, M. C., MacLaine, J. K., Wong, R. W., & Rabie, B. M. ( 2013 ). Altered serum levels of the osteoclast-specific TRACP 5b isoform in Chinese children undergoing orthodontic treatment. European Journal of Orthodontics, 35 ( 2 ), 169 – 174. https://doi.org/10.1093/ejo/cjs013
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