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Relationship between the subgingival microbiome and menopausal hormone therapy use: The Buffalo OsteoPerio study

dc.contributor.authorSoliman, Ahmed I.
dc.contributor.authorLaMonte, Michael J.
dc.contributor.authorHovey, Kathleen M.
dc.contributor.authorMcSkimming, Daniel I.
dc.contributor.authorAndrews, Chris A.
dc.contributor.authorDiaz, Patricia I.
dc.contributor.authorBuck, Michael J.
dc.contributor.authorSun, Yijun
dc.contributor.authorMillen, Amy E.
dc.contributor.authorWactawski-Wende, Jean
dc.date.accessioned2022-12-05T16:40:12Z
dc.date.available2023-12-05 11:40:11en
dc.date.available2022-12-05T16:40:12Z
dc.date.issued2022-11
dc.identifier.citationSoliman, Ahmed I.; LaMonte, Michael J.; Hovey, Kathleen M.; McSkimming, Daniel I.; Andrews, Chris A.; Diaz, Patricia I.; Buck, Michael J.; Sun, Yijun; Millen, Amy E.; Wactawski-Wende, Jean (2022). "Relationship between the subgingival microbiome and menopausal hormone therapy use: The Buffalo OsteoPerio study." Journal of Periodontology 93(11): 1635-1648.
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.urihttps://hdl.handle.net/2027.42/175210
dc.description.abstractBackgroundThis study investigated the association between menopausal hormone therapy (HT) use and the subgingival microbiome, for which published information is limited.MethodsThis cross-sectional study included 1270 postmenopausal women, aged 53–81 years, who completed clinical examinations. Detailed information on HT use (type, delivery mode, duration) was obtained from questionnaires. HT use was categorized into three groups (never, former, current). 16S rRNA sequencing was performed on subgingival plaque samples obtained during dental examinations. Operational taxonomic units were centered log2-ratio (CLR) transformed to account for the compositional data structure. Analysis of variance was used to compare mean microbial relative abundances across HT categories with Benjamini-Hochberg correction.ResultsSignificantly higher alpha diversity (Shannon Index) and beta diversity (Aitchison distance) was observed in never compared with current HT users (p < 0.05, each). Of the total 245 microbial taxa identified, 18 taxa differed significantly among the three HT groups, 11 of which were higher in current users and seven of which were lower in current users as compared with never users (p < 0.05, each). Differences in relative abundance between never and current HT users were materially unchanged after adjustment for age, body mass index, and oral hygiene.ConclusionsRelative abundance of several subgingival bacteria differed significantly between never and current HT users in a cohort of postmenopausal women. Additional studies are needed to determine the extent that these relationships might account for the previously reported inverse association between HT use and periodontal disease in older women.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherpostmenopause
dc.subject.otherwomen
dc.subject.othermicrobiota
dc.subject.otherhormones
dc.subject.otherperiodontal disease
dc.titleRelationship between the subgingival microbiome and menopausal hormone therapy use: The Buffalo OsteoPerio study
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175210/1/jper10966-sup-0001-FigureS1.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175210/2/jper10966_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175210/3/jper10966.pdf
dc.identifier.doi10.1002/JPER.22-0027
dc.identifier.sourceJournal of Periodontology
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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