Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment
dc.contributor.author | Zhang, Wei | |
dc.contributor.author | Oraiqat, Ibrahim | |
dc.contributor.author | Litzenberg, Dale | |
dc.contributor.author | Chang, Kai-Wei | |
dc.contributor.author | Hadley, Scott | |
dc.contributor.author | Sunbul, Noora Ba | |
dc.contributor.author | Matuszak, Martha M | |
dc.contributor.author | Tichacek, Christopher J | |
dc.contributor.author | Moros, Eduardo G | |
dc.contributor.author | Carson, Paul L | |
dc.contributor.author | Cuneo, Kyle C | |
dc.contributor.author | Wang, Xueding | |
dc.contributor.author | El Naqa, Issam | |
dc.date.accessioned | 2023-01-03T22:11:09Z | |
dc.date.available | 2023-01-03T22:11:09Z | |
dc.date.issued | 2023-01-02 | |
dc.identifier.issn | 1087-0156 | |
dc.identifier.issn | 1546-1696 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/175349 | |
dc.description.abstract | <jats:title>Abstract</jats:title><jats:p>Ionizing radiation acoustic imaging (iRAI) allows online monitoring of radiation’s interactions with tissues during radiation therapy, providing real-time, adaptive feedback for cancer treatments. We describe an iRAI volumetric imaging system that enables mapping of the three-dimensional (3D) radiation dose distribution in a complex clinical radiotherapy treatment. The method relies on a two-dimensional matrix array transducer and a matching multi-channel preamplifier board. The feasibility of imaging temporal 3D dose accumulation was first validated in a tissue-mimicking phantom. Next, semiquantitative iRAI relative dose measurements were verified in vivo in a rabbit model. Finally, real-time visualization of the 3D radiation dose delivered to a patient with liver metastases was accomplished with a clinical linear accelerator. These studies demonstrate the potential of iRAI to monitor and quantify the 3D radiation dose deposition during treatment, potentially improving radiotherapy treatment efficacy using real-time adaptive treatment.</jats:p> | |
dc.language | en | |
dc.publisher | Springer Science and Business Media LLC | |
dc.title | Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment | |
dc.type | Article | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/175349/2/Zhang_NatureBioTech_Acoustic Imaging Liver SBRT.pdf | |
dc.identifier.doi | 10.1038/s41587-022-01593-8 | |
dc.identifier.doi | https://dx.doi.org/10.7302/6730 | |
dc.identifier.source | Nature Biotechnology | |
dc.description.version | Published online | |
dc.date.updated | 2023-01-03T22:11:03Z | |
dc.identifier.orcid | 0000-0002-2539-8321 | |
dc.identifier.orcid | 0000-0001-8883-2175 | |
dc.identifier.orcid | 0000-0003-4432-2346 | |
dc.identifier.orcid | 0000-0003-1964-2460 | |
dc.identifier.orcid | 0000-0003-3543-7424 | |
dc.identifier.orcid | 0000-0002-8264-6483 | |
dc.identifier.orcid | 0000-0002-2974-6258 | |
dc.identifier.orcid | 0000-0001-6023-1132 | |
dc.identifier.name-orcid | Zhang, Wei; 0000-0002-2539-8321 | |
dc.identifier.name-orcid | Oraiqat, Ibrahim | |
dc.identifier.name-orcid | Litzenberg, Dale; 0000-0001-8883-2175 | |
dc.identifier.name-orcid | Chang, Kai-Wei; 0000-0003-4432-2346 | |
dc.identifier.name-orcid | Hadley, Scott | |
dc.identifier.name-orcid | Sunbul, Noora Ba | |
dc.identifier.name-orcid | Matuszak, Martha M | |
dc.identifier.name-orcid | Tichacek, Christopher J | |
dc.identifier.name-orcid | Moros, Eduardo G; 0000-0003-1964-2460 | |
dc.identifier.name-orcid | Carson, Paul L; 0000-0003-3543-7424 | |
dc.identifier.name-orcid | Cuneo, Kyle C; 0000-0002-8264-6483 | |
dc.identifier.name-orcid | Wang, Xueding; 0000-0002-2974-6258 | |
dc.identifier.name-orcid | El Naqa, Issam; 0000-0001-6023-1132 | |
dc.working.doi | 10.7302/6730 | en |
dc.owningcollname | Radiation Oncology, Department of |
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