Assessment of Systemic and Gastrointestinal Tissue Damage Biomarkers for GVHD Risk Stratification.
dc.contributor.author | Etra, AM | |
dc.contributor.author | Gergoudis, SC | |
dc.contributor.author | Morales, G | |
dc.contributor.author | Spyrou, N | |
dc.contributor.author | Shah, J | |
dc.contributor.author | Kowalyk, S | |
dc.contributor.author | Ayuk, FA | |
dc.contributor.author | Baez, J | |
dc.contributor.author | Chanswangphuwana, C | |
dc.contributor.author | Chen, YB | |
dc.contributor.author | Choe, HK | |
dc.contributor.author | DeFilipp, Z | |
dc.contributor.author | Gandhi, I | |
dc.contributor.author | Hexner, E | |
dc.contributor.author | Hogan, WJ | |
dc.contributor.author | Holler, E | |
dc.contributor.author | Kapoor, U | |
dc.contributor.author | Kitko, CL | |
dc.contributor.author | Kraus, S | |
dc.contributor.author | Lin, JY | |
dc.contributor.author | Al Malki, MM | |
dc.contributor.author | Merli, P | |
dc.contributor.author | Pawarode, A | |
dc.contributor.author | Pulsipher, MA | |
dc.contributor.author | Qayed, M | |
dc.contributor.author | Reshef, R | |
dc.contributor.author | Roesler, W | |
dc.contributor.author | Schechter, T | |
dc.contributor.author | Van Hyfte, G | |
dc.contributor.author | Weber, D | |
dc.contributor.author | Wolfl, M | |
dc.contributor.author | Young, R | |
dc.contributor.author | Özbek, U | |
dc.contributor.author | Ferrara, JL | |
dc.contributor.author | Levine, JE | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2023-01-07T03:26:36Z | |
dc.date.available | 2023-01-07T03:26:36Z | |
dc.date.issued | 2022-01-20 | |
dc.identifier.issn | 2473-9529 | |
dc.identifier.issn | 2473-9537 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/35443021 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/175358 | en |
dc.description.abstract | We used a rigorous PRoBE (prospective-specimen collection, retrospective-blinded-evaluation) study design to compare the ability of biomarkers of systemic inflammation and biomarkers of gastrointestinal (GI) tissue damage to predict response to corticosteroid treatment, the incidence of clinically severe disease, 6-month nonrelapse mortality (NRM), and overall survival in patients with acute graft-versus-host disease (GVHD). We prospectively collected serum samples of newly diagnosed GVHD patients (n = 730) from 19 centers, divided them into training (n = 352) and validation (n = 378) cohorts, and measured TNFR1, TIM3, IL6, ST2, and REG3a via enzyme-linked immunosorbent assay. Performances of the 4 strongest algorithms from the training cohort (TNFR1 + TIM3, TNFR1 + ST2, TNFR1 + REG3a, and ST2 + REG3a) were evaluated in the validation cohort. The algorithm that included only biomarkers of systemic inflammation (TNFR1 + TIM3) had a significantly smaller area under the curve (AUC; 0.57) than the AUCs of algorithms that contained ≥1 GI damage biomarker (TNFR1 + ST2, 0.70; TNFR1 + REG3a, 0.73; ST2 + REG3a, 0.79; all P < .001). All 4 algorithms were able to predict short-term outcomes such as response to systemic corticosteroids and severe GVHD, but the inclusion of a GI damage biomarker was needed to predict long-term outcomes such as 6-month NRM and survival. The algorithm that included 2 GI damage biomarkers was the most accurate of the 4 algorithms for all endpoints. | |
dc.format.medium | ||
dc.language | eng | |
dc.publisher | American Society of Hematology | |
dc.subject | Biomarkers | |
dc.subject | Graft vs Host Disease | |
dc.subject | Hematopoietic Stem Cell Transplantation | |
dc.subject | Hepatitis A Virus Cellular Receptor 2 | |
dc.subject | Humans | |
dc.subject | Inflammation | |
dc.subject | Interleukin-1 Receptor-Like 1 Protein | |
dc.subject | Prospective Studies | |
dc.subject | Receptors, Tumor Necrosis Factor, Type I | |
dc.subject | Retrospective Studies | |
dc.subject | Risk Assessment | |
dc.title | Assessment of Systemic and Gastrointestinal Tissue Damage Biomarkers for GVHD Risk Stratification. | |
dc.type | Article | |
dc.identifier.pmid | 35443021 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/175358/2/Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification.pdf | |
dc.identifier.doi | 10.1182/bloodadvances.2022007296 | |
dc.identifier.doi | https://dx.doi.org/10.7302/6739 | |
dc.identifier.source | Blood advances | |
dc.description.version | Published version | |
dc.date.updated | 2023-01-07T03:26:34Z | |
dc.identifier.orcid | 0000-0001-6323-9623 | |
dc.description.filedescription | Description of Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification.pdf : Published version | |
dc.identifier.volume | 2022 Apr 20 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 3707 | |
dc.identifier.endpage | 3715 | |
dc.identifier.name-orcid | Etra, AM | |
dc.identifier.name-orcid | Gergoudis, SC | |
dc.identifier.name-orcid | Morales, G | |
dc.identifier.name-orcid | Spyrou, N | |
dc.identifier.name-orcid | Shah, J | |
dc.identifier.name-orcid | Kowalyk, S | |
dc.identifier.name-orcid | Ayuk, FA | |
dc.identifier.name-orcid | Baez, J | |
dc.identifier.name-orcid | Chanswangphuwana, C | |
dc.identifier.name-orcid | Chen, YB | |
dc.identifier.name-orcid | Choe, HK | |
dc.identifier.name-orcid | DeFilipp, Z | |
dc.identifier.name-orcid | Gandhi, I | |
dc.identifier.name-orcid | Hexner, E | |
dc.identifier.name-orcid | Hogan, WJ | |
dc.identifier.name-orcid | Holler, E | |
dc.identifier.name-orcid | Kapoor, U | |
dc.identifier.name-orcid | Kitko, CL | |
dc.identifier.name-orcid | Kraus, S | |
dc.identifier.name-orcid | Lin, JY | |
dc.identifier.name-orcid | Al Malki, MM | |
dc.identifier.name-orcid | Merli, P | |
dc.identifier.name-orcid | Pawarode, A; 0000-0001-6323-9623 | |
dc.identifier.name-orcid | Pulsipher, MA | |
dc.identifier.name-orcid | Qayed, M | |
dc.identifier.name-orcid | Reshef, R | |
dc.identifier.name-orcid | Roesler, W | |
dc.identifier.name-orcid | Schechter, T | |
dc.identifier.name-orcid | Van Hyfte, G | |
dc.identifier.name-orcid | Weber, D | |
dc.identifier.name-orcid | Wolfl, M | |
dc.identifier.name-orcid | Young, R | |
dc.identifier.name-orcid | Özbek, U | |
dc.identifier.name-orcid | Ferrara, JL | |
dc.identifier.name-orcid | Levine, JE | |
dc.working.doi | 10.7302/6739 | en |
dc.owningcollname | Internal Medicine, Department of |
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