View Item 

Show simple item record

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential
dc.contributor.authorWorthley, DL
dc.contributor.authorChurchill, M
dc.contributor.authorCompton, JT
dc.contributor.authorTailor, Y
dc.contributor.authorRao, M
dc.contributor.authorSi, Y
dc.contributor.authorLevin, D
dc.contributor.authorSchwartz, MG
dc.contributor.authorUygur, A
dc.contributor.authorHayakawa, Y
dc.contributor.authorGross, S
dc.contributor.authorRenz, BW
dc.contributor.authorSetlik, W
dc.contributor.authorMartinez, AN
dc.contributor.authorChen, X
dc.contributor.authorNizami, S
dc.contributor.authorLee, HG
dc.contributor.authorKang, HP
dc.contributor.authorCaldwell, JM
dc.contributor.authorAsfaha, S
dc.contributor.authorWestphalen, CB
dc.contributor.authorGraham, T
dc.contributor.authorJin, G
dc.contributor.authorNagar, K
dc.contributor.authorWang, H
dc.contributor.authorKheirbek, MA
dc.contributor.authorKolhe, A
dc.contributor.authorCarpenter, J
dc.contributor.authorGlaire, M
dc.contributor.authorNair, A
dc.contributor.authorRenders, S
dc.contributor.authorManieri, N
dc.contributor.authorMuthupalani, S
dc.contributor.authorFox, JG
dc.contributor.authorReichert, M
dc.contributor.authorGiraud, AS
dc.contributor.authorSchwabe, RF
dc.contributor.authorPradere, JP
dc.contributor.authorWalton, K
dc.contributor.authorPrakash, A
dc.contributor.authorGumucio, D
dc.contributor.authorRustgi, AK
dc.contributor.authorStappenbeck, TS
dc.contributor.authorFriedman, RA
dc.contributor.authorGershon, MD
dc.contributor.authorSims, P
dc.contributor.authorGrikscheit, T
dc.contributor.authorLee, FY
dc.contributor.authorKarsenty, G
dc.contributor.authorMukherjee, S
dc.contributor.authorWang, TC
dc.coverage.spatialUnited States
dc.date.accessioned2023-01-09T17:58:20Z
dc.date.available2023-01-09T17:58:20Z
dc.date.issued2015-01-15
dc.identifier.issn0092-8674
dc.identifier.issn1097-4172
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/25594183
dc.identifier.urihttps://hdl.handle.net/2027.42/175371en
dc.description.abstractThe stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow. OCR stem cells self-renew and generate osteoblasts, chondrocytes, and reticular marrow stromal cells, but not adipocytes. OCR stem cells are concentrated within the metaphysis of long bones not in the perisinusoidal space and are needed for bone development, bone remodeling, and fracture repair. Grem1 expression also identifies intestinal reticular stem cells (iRSCs) that are cells of origin for the periepithelial intestinal mesenchymal sheath. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs).
dc.format.mediumPrint
dc.languageeng
dc.publisherElsevier
dc.subjectAnimals
dc.subjectBone and Bones
dc.subjectCartilage
dc.subjectIntercellular Signaling Peptides and Proteins
dc.subjectIntestine, Small
dc.subjectMesenchymal Stem Cells
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.titleGremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential
dc.typeArticle
dc.identifier.pmid25594183
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175371/2/1-s2.0-S0092867414015190-main.pdf
dc.identifier.doi10.1016/j.cell.2014.11.042
dc.identifier.doihttps://dx.doi.org/10.7302/6752
dc.identifier.sourceCell
dc.description.versionPublished version
dc.date.updated2023-01-09T17:58:17Z
dc.identifier.orcid0000-0001-9108-5617
dc.description.filedescriptionDescription of 1-s2.0-S0092867414015190-main.pdf : Published version
dc.identifier.volume160
dc.identifier.issue1-2
dc.identifier.startpage269
dc.identifier.endpage284
dc.identifier.name-orcidWorthley, DL
dc.identifier.name-orcidChurchill, M
dc.identifier.name-orcidCompton, JT
dc.identifier.name-orcidTailor, Y
dc.identifier.name-orcidRao, M
dc.identifier.name-orcidSi, Y
dc.identifier.name-orcidLevin, D
dc.identifier.name-orcidSchwartz, MG
dc.identifier.name-orcidUygur, A
dc.identifier.name-orcidHayakawa, Y
dc.identifier.name-orcidGross, S
dc.identifier.name-orcidRenz, BW
dc.identifier.name-orcidSetlik, W
dc.identifier.name-orcidMartinez, AN
dc.identifier.name-orcidChen, X
dc.identifier.name-orcidNizami, S
dc.identifier.name-orcidLee, HG
dc.identifier.name-orcidKang, HP
dc.identifier.name-orcidCaldwell, JM
dc.identifier.name-orcidAsfaha, S
dc.identifier.name-orcidWestphalen, CB
dc.identifier.name-orcidGraham, T
dc.identifier.name-orcidJin, G
dc.identifier.name-orcidNagar, K
dc.identifier.name-orcidWang, H
dc.identifier.name-orcidKheirbek, MA
dc.identifier.name-orcidKolhe, A
dc.identifier.name-orcidCarpenter, J
dc.identifier.name-orcidGlaire, M
dc.identifier.name-orcidNair, A
dc.identifier.name-orcidRenders, S
dc.identifier.name-orcidManieri, N
dc.identifier.name-orcidMuthupalani, S
dc.identifier.name-orcidFox, JG
dc.identifier.name-orcidReichert, M
dc.identifier.name-orcidGiraud, AS
dc.identifier.name-orcidSchwabe, RF
dc.identifier.name-orcidPradere, JP
dc.identifier.name-orcidWalton, K; 0000-0001-9108-5617
dc.identifier.name-orcidPrakash, A
dc.identifier.name-orcidGumucio, D
dc.identifier.name-orcidRustgi, AK
dc.identifier.name-orcidStappenbeck, TS
dc.identifier.name-orcidFriedman, RA
dc.identifier.name-orcidGershon, MD
dc.identifier.name-orcidSims, P
dc.identifier.name-orcidGrikscheit, T
dc.identifier.name-orcidLee, FY
dc.identifier.name-orcidKarsenty, G
dc.identifier.name-orcidMukherjee, S
dc.identifier.name-orcidWang, TC
dc.working.doi10.7302/6752en
dc.owningcollnameInternal Medicine, Department of


Files in this item

Name:
1-s2.0-S0092867414015190-main.pdf
Size:
6.988MB
Format:
PDF
Description:
Published version
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.