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Immunomodulatory fibrous hyaluronic acid-Fmoc-diphenylalanine-based hydrogel induces bone regeneration
dc.contributor.authorHalperin-Sternfeld, Michal
dc.contributor.authorPokhojaev, Ariel
dc.contributor.authorGhosh, Moumita
dc.contributor.authorRachmiel, Dana
dc.contributor.authorKannan, Raha
dc.contributor.authorGrinberg, Itzhak
dc.contributor.authorAsher, Moshe
dc.contributor.authorAviv, Moran
dc.contributor.authorMa, Peter X.
dc.contributor.authorBinderman, Itzhak
dc.contributor.authorSarig, Rachel
dc.contributor.authorAdler-Abramovich, Lihi
dc.date.accessioned2023-02-01T18:56:54Z
dc.date.available2024-03-01 13:56:48en
dc.date.available2023-02-01T18:56:54Z
dc.date.issued2023-02
dc.identifier.citationHalperin-Sternfeld, Michal ; Pokhojaev, Ariel; Ghosh, Moumita; Rachmiel, Dana; Kannan, Raha; Grinberg, Itzhak; Asher, Moshe; Aviv, Moran; Ma, Peter X.; Binderman, Itzhak; Sarig, Rachel; Adler-Abramovich, Lihi (2023). "Immunomodulatory fibrous hyaluronic acid- Fmoc- diphenylalanine- based hydrogel induces bone regeneration." Journal of Clinical Periodontology 50(2): 200-219.
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.urihttps://hdl.handle.net/2027.42/175732
dc.description.abstractAimTo investigate the potential of an ultrashort aromatic peptide hydrogelator integrated with hyaluronic acid (HA) to serve as a scaffold for bone regeneration.Materials and MethodsFluorenylmethyloxycarbonyl-diphenylalanine (FmocFF)/HA hydrogel was prepared and characterized using microscopy and rheology. Osteogenic differentiation of MC3T3-E1 preosteoblasts was investigated using Alizarin red, alkaline phosphatase and calcium deposition assays. In vivo, 5-mm-diameter calvarial critical-sized defects were prepared in 20 Sprague–Dawley rats and filled with either FmocFF/HA hydrogel, deproteinized bovine bone mineral, FmocFF/Alginate hydrogel or left unfilled. Eight weeks after implantation, histology and micro-computed tomography analyses were performed. Immunohistochemistry was performed in six rats to assess the hydrogel’s immunomodulatory effect.ResultsA nanofibrous FmocFF/HA hydrogel with a high storage modulus of 46 KPa was prepared. It supported osteogenic differentiation of MC3T3-E1 preosteoblasts and facilitated calcium deposition. In vivo, the hydrogel implantation resulted in approximately 93% bone restoration. It induced bone deposition not only around the margins, but also generated bony islets along the defect. Elongated M2 macrophages lining at the periosteum–hydrogel interface were observed 1 week after implantation. After 3 weeks, these macrophages were dispersed through the regenerating tissue surrounding the newly formed bone.ConclusionsFmocFF/HA hydrogel can serve as a cell-free, biomimetic, immunomodulatory scaffold for bone regeneration.
dc.publisherWiley Periodicals, Inc.
dc.publisherBlackwell Publishing Ltd
dc.subject.otherhyaluronic acid
dc.subject.otherimmunomodulation
dc.subject.otherself-assembling peptides
dc.subject.otherbone regeneration
dc.subject.otherbiomaterials
dc.titleImmunomodulatory fibrous hyaluronic acid-Fmoc-diphenylalanine-based hydrogel induces bone regeneration
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175732/1/jcpe13725_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175732/2/jcpe13725.pdf
dc.identifier.doi10.1111/jcpe.13725
dc.identifier.sourceJournal of Clinical Periodontology
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