SARS-CoV-2 infection-induced immunity and the duration of viral shedding: Results from a Nicaraguan household cohort study
dc.contributor.author | Maier, Hannah E. | |
dc.contributor.author | Plazaola, Miguel | |
dc.contributor.author | Lopez, Roger | |
dc.contributor.author | Sanchez, Nery | |
dc.contributor.author | Saborio, Saira | |
dc.contributor.author | Ojeda, Sergio | |
dc.contributor.author | Barilla, Carlos | |
dc.contributor.author | Kuan, Guillermina | |
dc.contributor.author | Balmaseda, Angel | |
dc.contributor.author | Gordon, Aubree | |
dc.date.accessioned | 2023-02-01T18:57:51Z | |
dc.date.available | 2024-02-01 13:57:50 | en |
dc.date.available | 2023-02-01T18:57:51Z | |
dc.date.issued | 2023-01 | |
dc.identifier.citation | Maier, Hannah E.; Plazaola, Miguel; Lopez, Roger; Sanchez, Nery; Saborio, Saira; Ojeda, Sergio; Barilla, Carlos; Kuan, Guillermina; Balmaseda, Angel; Gordon, Aubree (2023). "SARS-CoV-2 infection-induced immunity and the duration of viral shedding: Results from a Nicaraguan household cohort study." Influenza and Other Respiratory Viruses 17(1): n/a-n/a. | |
dc.identifier.issn | 1750-2640 | |
dc.identifier.issn | 1750-2659 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/175755 | |
dc.description.abstract | BackgroundMuch of the world’s population has been infected with SARS-CoV-2. Thus, immunity from prior infection will play a critical role in future SARS-CoV-2 transmission. We investigated the impact of infection-induced immunity on viral shedding duration and viral load.MethodsWe conducted a household cohort study in Managua, Nicaragua, with an embedded transmission study that closely monitors participants regardless of symptoms. Real-time reverse-transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assays (ELISAs) were used to measure infections and seropositivity, respectively. Blood samples were collected twice annually and surrounding household intensive monitoring periods. We used accelerated failure time models to compare shedding times. Participants vaccinated ≥14 days prior to infection were excluded from primary analyses.ResultsThere were 600 RT-PCR-confirmed SARS-CoV-2 infections in unvaccinated participants between May 1, 2020, and March 10, 2022, with prior ELISA data. Prior infection was associated with 48% shorter shedding times (event time ratio [ETR] 0.52, 95% CI: 0.39–0.69, mean shedding: 13.7 vs. 26.4 days). A fourfold higher anti-SARS-CoV-2 spike titer was associated with 17% shorter shedding (ETR 0.83, 95% CI: 0.78–0.90). Similarly, maximum viral loads (lowest cycle threshold [CT]) were lower for previously infected individuals (mean CT 29.8 vs. 28.0, p = 4.02 × 10−3), for adults and children ≥10 years, but not for children 0–9 years; there was little difference in CT levels for previously infected versus naïve adults aged above 60 years.ConclusionsPrior infection-induced immunity was associated with shorter viral shedding and lower viral loads, which may be important in the transition from pandemic to endemicity. | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.publisher | Our World in Data | |
dc.subject.other | SARS-CoV-2 | |
dc.subject.other | immunity | |
dc.subject.other | COVID-19 | |
dc.subject.other | viral shedding | |
dc.subject.other | reinfection | |
dc.title | SARS-CoV-2 infection-induced immunity and the duration of viral shedding: Results from a Nicaraguan household cohort study | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Microbiology and Immunology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/175755/1/irv13074_am.pdf | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/175755/2/irv13074.pdf | |
dc.identifier.doi | 10.1111/irv.13074 | |
dc.identifier.source | Influenza and Other Respiratory Viruses | |
dc.identifier.citedreference | Maier HE, Kuan G, Saborio S, et al. Clinical spectrum of SARS-CoV-2 infection and protection from symptomatic re-infection. Clin Infect Dis. 2022b; 75 ( 1 ): e257 - e266. doi: 10.1093/cid/ciab717 | |
dc.identifier.citedreference | Barber RM, Sorensen RJD, Pigott DM, et al. Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis. Lancet. 2022; 399 ( 10344 ): 2351 - 2380. doi: 10.1016/S0140-6736(22)00484-6 | |
dc.identifier.citedreference | Hubeaux S, Rufibach K. SurvRegCensCov: Weibull Regression for a Right-Censored Endpoint with Interval-Censored Covariate. R package version 1.4. 2015. | |
dc.identifier.citedreference | Maier HE, Balmaseda A, Saborio S, et al. Protection associated with previous SARS-CoV-2 infection in Nicaragua. N Engl J Med. 2022a; 387 ( 6 ): 568 - 570. doi: 10.1056/NEJMc2203985 | |
dc.identifier.citedreference | Amanat F, Stadlbauer D, Strohmeier S, et al. A serological assay to detect SARS-CoV-2 seroconversion in humans. Nat Med. 2020; 26 ( 7 ): 1033 - 1036. doi: 10.1038/s41591-020-0913-5 | |
dc.identifier.citedreference | Chu DKW, Pan Y, Cheng SMS, et al. Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia. Clin Chem. 2020; 66 ( 4 ): 549 - 555. doi: 10.1093/clinchem/hvaa029 | |
dc.identifier.citedreference | Ritchie H, Mathieu E, Rodés-Guirao L, et al. Coronavirus Pandemic (COVID-19). Our World in Data. 2020. | |
dc.identifier.citedreference | Abu-Raddad LJ, Chemaitelly H, Ayoub HH, et al. Relative infectiousness of SARS-CoV-2 vaccine breakthrough infections, reinfections, and primary infections. Nat Commun. 2022; 13 ( 1 ): 532. doi: 10.1038/s41467-022-28199-7 | |
dc.identifier.citedreference | Singanayagam A, Hakki S, Dunning J, et al. Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study. Lancet Infect Dis. 2022; 22 ( 2 ): 183 - 195. doi: 10.1016/S1473-3099(21)00648-4 | |
dc.identifier.citedreference | Cevik M, Tate M, Lloyd O, Maraolo AE, Schafers J, Ho A. SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis. Lancet Microbe. 2021; 2 ( 1 ): e13 - e22. doi: 10.1016/S2666-5247(20)30172-5 | |
dc.identifier.citedreference | Killingley B, Mann A, Kalinova M, et al. Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge. Nat Portfolio, preprint. 2022. doi: 10.21203/rs.3.rs-1121993/v1 | |
dc.identifier.citedreference | Hodcroft E, Neher R. Phylogenetic analysis of SARS-CoV-2 clusters in their international context - cluster 21K.Omicron. 2022. Retrieved from https://nextstrain.org/groups/neherlab/ncov/21K.Omicron | |
dc.identifier.citedreference | Wickham H, Averick M, Bryan J, et al. Welcome to the tidyverse. J Open Source Softw. 2019; 4 ( 43 ): 1686. doi: 10.21105/joss.01686 | |
dc.identifier.citedreference | R Core Team. R: A Language and Environment for Statistical Computing. 2021. | |
dc.identifier.citedreference | Thernau T. A Package for Survival Analysis in R. R package version 3.2–13. 2021. | |
dc.working.doi | NO | en |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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