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Cumulative loneliness and subsequent memory function and rate of decline among adults aged ≥50 in the United States, 1996 to 2016
dc.contributor.authorYu, Xuexin
dc.contributor.authorWestrick, Ashly C.
dc.contributor.authorKobayashi, Lindsay C.
dc.date.accessioned2023-03-03T21:08:28Z
dc.date.available2024-03-03 16:08:26en
dc.date.available2023-03-03T21:08:28Z
dc.date.issued2023-02
dc.identifier.citationYu, Xuexin; Westrick, Ashly C.; Kobayashi, Lindsay C. (2023). "Cumulative loneliness and subsequent memory function and rate of decline among adults aged ≥50 in the United States, 1996 to 2016." Alzheimer’s & Dementia 19(2): 578-588.
dc.identifier.issn1552-5260
dc.identifier.issn1552-5279
dc.identifier.urihttps://hdl.handle.net/2027.42/175885
dc.description.abstractIntroductionThe study objective was to investigate the association between loneliness duration and memory function over a 20-year period.MethodsData were from 9032 adults aged ≥50 in the Health and Retirement Study. Loneliness status (yes vs. no) was assessed biennially from 1996 to 2004 and its duration was categorized as never, 1 time point, 2 time points, and ≥3 time points. Episodic memory was assessed from 2004 to 2016 as a composite of immediate and delayed recall trials combined with proxy-reported memory. Mixed-effects linear regression models were fitted.ResultsA longer duration of loneliness was associated with lower memory scores (P < 0.001) and a faster rate of decline (P < 0.001). The association was stronger among adults aged ≥65 than those aged <65 (three-way interaction P = 0.013) and was stronger among women than men (three-way interaction P = 0.002).DiscussionCumulative loneliness may be a salient risk factor for accelerated memory aging, especially among women aged ≥65.HighlightA longer duration of loneliness was associated with accelerated memory aging.The association was stronger among women than men and among older adults than the younger.Reducing loneliness in mid- to late life may help maintain memory function.
dc.publisherInstitute for Social Research, University of Michigan
dc.publisherWiley Periodicals, Inc.
dc.subject.otherolder adults
dc.subject.otherUnited States
dc.subject.othermiddle aged
dc.subject.othermemory aging
dc.subject.otherloneliness trajectories
dc.titleCumulative loneliness and subsequent memory function and rate of decline among adults aged ≥50 in the United States, 1996 to 2016
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurology and Neurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175885/1/alz12734_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175885/2/alz12734.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175885/3/alz12734-sup-0002-SuppMatS2.pdf
dc.identifier.doi10.1002/alz.12734
dc.identifier.sourceAlzheimer’s & Dementia
dc.identifier.citedreferenceHawkley LC, Thisted RA, Masi CM, Cacioppo JT. Loneliness predicts increased blood pressure: 5-year cross-lagged analyses in middle-aged and older adults. Psychol Aging. 2010; 25 ( 1 ): 132 - 141. doi: 10.1037/a0017805
dc.identifier.citedreferenceVan Dongen HPA, Olofsen E, Dinges DF, Maislin G. Mixed-model regression analysis and dealing with interindividual differences. Methods in Enzymology. Academic Press; 2004; 384: 139 - 171.
dc.identifier.citedreferenceWeuve J, Tchetgen EJ, Glymour MM, et al. Accounting for bias due to selective attrition: the example of smoking and cognitive decline. Epidemiology. 2012; 23 ( 1 ): 119 - 128. doi: 10.1097/EDE.0b013e318230e861
dc.identifier.citedreferenceRobins JM, Hernán MA, Brumback B. Marginal structural models and causal inference in epidemiology. Epidemiology. 2000; 11 ( 5 ): 550 - 560. doi: 10.1097/00001648-200009000-00011
dc.identifier.citedreferencePool LR, Burgard SA, Needham BL, Elliott MR, Langa KM, Mendes de Leon CF. Association of a negative wealth shock with all-cause mortality in middle-aged and older adults in the United States. JAMA. 2018; 319 ( 13 ): 1341 - 1350. doi: 10.1001/jama.2018.2055
dc.identifier.citedreferenceCacioppo JT, Hawkley LC, Ernst JM, et al. Loneliness within a nomological net: an evolutionary perspective. J Res Pers. 2006; 40 ( 6 ): 1054 - 1085. doi: 10.1016/j.jrp.2005.11.007
dc.identifier.citedreferenceAkerlind I, Hörnquist JO. Loneliness and alcohol abuse: a review of evidences of an interplay. Soc Sci Med. 1992; 34 ( 4 ): 405 - 414. doi: 10.1016/0277-9536(92)90300-f
dc.identifier.citedreferenceHawkley LC, Thisted RA, Cacioppo JT. Loneliness predicts reduced physical activity: cross-sectional & longitudinal analyses. Health Psychol. 2009; 28 ( 3 ): 354 - 363. doi: 10.1037/a0014400
dc.identifier.citedreferenceDyal SR, Valente TW. A systematic review of loneliness and smoking: small effects, big implications. Subst Use Misuse. 2015; 50 ( 13 ): 1697 - 1716. doi: 10.3109/10826084.2015.1027933
dc.identifier.citedreferenceKurina LM, Knutson KL, Hawkley LC, Cacioppo JT, Lauderdale DS, Ober C. Loneliness is associated with sleep fragmentation in a communal society. Sleep. 2011; 34 ( 11 ): 1519 - 1526. doi: 10.5665/sleep.1390
dc.identifier.citedreferenceValtorta NK, Kanaan M, Gilbody S, Ronzi S, Hanratty B. Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies. Heart. 2016; 102 ( 13 ): 1009 - 1016. doi: 10.1136/heartjnl-2015-308790
dc.identifier.citedreferenceLee SL, Pearce E, Ajnakina O, et al. The association between loneliness and depressive symptoms among adults aged 50 years and older: a 12-year population-based cohort study. Lancet Psychiatry. 2021; 8 ( 1 ): 48 - 57. doi: 10.1016/S2215-0366(20)30383-7
dc.identifier.citedreferenceJu YS, Ooms SJ, Sutphen C, et al. Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels. Brain. 2017; 140 ( 8 ): 2104 - 2111. doi: 10.1093/brain/awx148
dc.identifier.citedreferenceSpira AP, Chen-Edinboro LP, Wu MN, Yaffe K. Impact of sleep on the risk of cognitive decline and dementia. Curr Opin Psychiatry. 2014; 27 ( 6 ): 478 - 483. doi: 10.1097/YCO.0000000000000106
dc.identifier.citedreferenceLivingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020; 396 ( 10248 ): 413 - 446. doi: 10.1016/S0140-6736(20)30367-6
dc.identifier.citedreferenceZeki Al Hazzouri A, Caunca MR, Nobrega JC, et al. Greater depressive symptoms, cognition, and markers of brain aging. Northern Manhattan Study. Neurology. 2018; 90 ( 23 ): e2077 - e2085. doi: 10.1212/wnl.0000000000005639
dc.identifier.citedreferenceOng AD, Rothstein JD, Uchino BN. Loneliness accentuates age differences in cardiovascular responses to social evaluative threat. Psychol Aging. 2012; 27 ( 1 ): 190 - 198. doi: 10.1037/a0025570
dc.identifier.citedreferenceHawkley LC, Masi CM, Berry JD, Cacioppo JT. Loneliness is a unique predictor of age-related differences in systolic blood pressure. Psychol Aging. 2006; 21 ( 1 ): 152 - 164. doi: 10.1037/0882-7974.21.1.152
dc.identifier.citedreferenceBoehlen FH, Maatouk I, Friederich H-C, Schoettker B, Brenner H, Wild B. Loneliness as a gender-specific predictor of physical and mental health-related quality of life in older adults. Qual Life Res. 2021; 31 ( 7 ): 2023 - 2033. doi: 10.1007/s11136-021-03055-1
dc.identifier.citedreferenceLiu H, Zhang M, Yang Q, Yu B. Gender differences in the influence of social isolation and loneliness on depressive symptoms in college students: a longitudinal study. Soc Psychiatry Psychiatr Epidemiol. 2020; 55 ( 2 ): 251 - 257. doi: 10.1007/s00127-019-01726-6
dc.identifier.citedreferenceZhou Z, Wang P, Fang Y. Loneliness and the risk of dementia among older Chinese adults: gender differences. Aging Ment Health. 2018; 22 ( 4 ): 519 - 525. doi: 10.1080/13607863.2016.1277976
dc.identifier.citedreferenceBorys S, Perlman D. Gender differences in loneliness. Pers Soc Psychol Bull. 1985; 11 ( 1 ): 63 - 74. doi: 10.1177/0146167285111006
dc.identifier.citedreferenceRussell DW. UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. J Pers Assess. 1996; 66 ( 1 ): 20 - 40. doi: 10.1207/s15327752jpa6601_2
dc.identifier.citedreferenceEvans IEM, Llewellyn DJ, Matthews FE, et al. Living alone and cognitive function in later life. Arch Gerontol Geriatr. 2019; 81: 222 - 233. doi: 10.1016/j.archger.2018.12.014
dc.identifier.citedreferenceWilson RS, Krueger KR, Arnold SE, et al. Loneliness and risk of Alzheimer disease. Arch Gen Psychiatry. 2007; 64 ( 2 ): 234 - 240. doi: 10.1001/archpsyc.64.2.234
dc.identifier.citedreferenceRafnsson SB, Orrell M, d’Orsi E, Hogervorst E, Steptoe A. Loneliness, social integration, and incident dementia over 6 years: prospective findings from the English Longitudinal Study of Ageing. J Gerontol B Psychol Sci Sco Sci. 2017; 75 ( 1 ): 114 - 124. doi: 10.1093/geronb/gbx087
dc.identifier.citedreferenceShankar A, Hamer M, McMunn A, Steptoe A. Social isolation and loneliness: relationships with cognitive function during 4 years of follow-up in the English longitudinal study of ageing. Psychosom Med. 2013; 75 ( 2 ): 161 - 170. doi: 10.1097/PSY.0b013e31827f09cd
dc.identifier.citedreferenceHolwerda TJ, Deeg DJ, Beekman AT, et al. Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL). J Neurol Neurosurg Psychiatry. 2014; 85 ( 2 ): 135 - 142. doi: 10.1136/jnnp-2012-302755
dc.identifier.citedreferencePoey JL, Burr JA, Roberts JS. Social connectedness, perceived isolation, and dementia: does the social environment moderate the relationship between genetic risk and cognitive well-being? Gerontologist. 2017; 57 ( 6 ): 1031 - 1040. doi: 10.1093/geront/gnw154
dc.identifier.citedreferenceBoss L, Kang DH, Branson S. Loneliness and cognitive function in the older adult: a systematic review. Int Psychogeriatr. 2015; 27 ( 4 ): 541 - 553. doi: 10.1017/s1041610214002749
dc.identifier.citedreferenceDonovan NJ, Wu Q, Rentz DM, Sperling RA, Marshall GA, Glymour MM. Loneliness, depression and cognitive function in older U.S. adults. Int J Geriatr Psychiatry. 2017; 32 ( 5 ): 564 - 573. doi: 10.1002/gps.4495
dc.identifier.citedreferenceSmoyak SA. Loneliness: a sourcebook of current theory, research and therapy. J Psychosoc Nurs Ment Health Ser. 1984; 22 ( 6 ): 40 - 41. doi: 10.3928/0279-3695-19840601-09
dc.identifier.citedreferenceMund M, Freuding MM, Möbius K, Horn N, Neyer FJ. The stability and change of loneliness across the life span: a meta-analysis of longitudinal studies. Pers Soc Psychol Rev. 2020; 24 ( 1 ): 24 - 52. doi: 10.1177/1088868319850738
dc.identifier.citedreferenceSaczynski JS, Pfeifer LA, Masaki K, et al. The effect of social engagement on incident dementia: the Honolulu-Asia Aging Study. Am J Epidemiol. 2006; 163 ( 5 ): 433 - 440. doi: 10.1093/aje/kwj061
dc.identifier.citedreferenceSutin AR, Stephan Y, Luchetti M, Terracciano A. Loneliness and risk of dementia. J Gerontol B Psychol Sci Sco Sci. 2018; 75 ( 7 ): 1414 - 1422. doi: 10.1093/geronb/gby112
dc.identifier.citedreferenceRawtaer I, Gao Q, Nyunt MSZ, et al. Psychosocial risk and protective factors and incident mild cognitive impairment and dementia in community dwelling elderly: findings from the Singapore Longitudinal Ageing Study. J Alzheimers Dis. 2017; 57: 603 - 611. doi: 10.3233/JAD-160862
dc.identifier.citedreferenceOkely JA, Deary IJ. Longitudinal associations between loneliness and cognitive ability in the Lothian Birth Cohort 1936. J Gerontol B Psychol Sci Soc Sci. 2019; 74 ( 8 ): 1376 - 1386. doi: 10.1093/geronb/gby086
dc.identifier.citedreferenceKaup AR, Byers AL, Falvey C, et al. Trajectories of depressive symptoms in older adults and risk of dementia. JAMA Psychiatry. 2016; 73 ( 5 ): 525 - 531. doi: 10.1001/jamapsychiatry.2016.0004
dc.identifier.citedreferenceLi G, Wang LY, Shofer JB, et al. Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study. Arch Gen Psychiatry. 2011; 68 ( 9 ): 970 - 977. doi: 10.1001/archgenpsychiatry.2011.86
dc.identifier.citedreferenceZhong BL, Chen SL, Tu X, Conwell Y. Loneliness and cognitive function in older adults: findings from the Chinese Longitudinal Healthy Longevity Survey. J Gerontol B Psychol Sci Sco Sci. 2017; 72 ( 1 ): 120 - 128. doi: 10.1093/geronb/gbw037
dc.identifier.citedreferenceAkhter-Khan SC, Tao Q, Ang TFA, et al. Associations of loneliness with risk of Alzheimer’s disease dementia in the Framingham Heart Study. Alzheimers Dement. 2021; 17 ( 10 ): 1619 - 1627. doi: 10.1002/alz.12327
dc.identifier.citedreferenceLara E, Caballero FF, Rico-Uribe LA, et al. Are loneliness and social isolation associated with cognitive decline? Int J Geriatr Psychiatry. 2019; 34 ( 11 ): 1613 - 1622. doi: 10.1002/gps.5174
dc.identifier.citedreferenceHawkley LC, Masi CM, Berry JD, Cacioppo JT. Loneliness is a unique predictor of age-related differences in systolic blood pressure. Psychol Aging. 2006; 21 ( 1 ): 152 - 164. doi: 10.1037/0882-7974.21.1.152
dc.identifier.citedreferenceYu B, Steptoe A, Niu K, Jia X. Social isolation and loneliness as risk factors for grip strength decline among older women and men in China. J Am Med Dir Assoc. 2020; 21 ( 12 ): 1926 - 1930. doi: 10.1016/j.jamda.2020.06.029
dc.identifier.citedreferenceWeiner MR, Monin JK, Mota N, Pietrzak RH. Age differences in the association of social support and mental health in male US veterans: results from the National Health and Resilience in Veterans Study. Am J Geriatr Psychiatry. 2016; 24 ( 4 ): 327 - 336. doi: 10.1016/j.jagp.2015.11.007
dc.identifier.citedreferenceAntonucci TC, Akiyama H. An examination of sex differences in social support among older men and women. Sex Roles. 1987; 17 ( 11 ): 737 - 749. doi: 10.1007/BF00287685
dc.identifier.citedreferenceSonnega A, Faul JD, Ofstedal MB, Langa KM, Phillips JW, Weir DR. Cohort profile: the health and retirement study (HRS). Int J Epidemiol. 2014; 43 ( 2 ): 576 - 585. doi: 10.1093/ije/dyu067
dc.identifier.citedreferenceLanga KM, Ryan LH, McCammon RJ, et al. The health and retirement study harmonized cognitive assessment protocol project: study design and methods. Neuroepidemiology. 2020; 54 ( 1 ): 64 - 74. doi: 10.1159/000503004
dc.identifier.citedreferenceSteffick DE. Documentation of affective functioning measures in the Health and Retirement Study. Ann Arbor, Michigan: Institute for Social Research, University of Michigan; 2020.
dc.identifier.citedreferenceLewinsohn PM, Seeley JR, Roberts RE, Allen NB. Center for epidemiologic studies depression scale (CES-D) as a screening instrument for depression among community-residing older adults. Psychol Aging. 1997; 12 ( 2 ): 277 - 287. doi: 10.1037//0882-7974.12.2.277
dc.identifier.citedreferenceMary Beth O, Gwenith GF, Herzog AR. Documentation of cognitive functioning measures in the Health and Retirement Study. Ann Arbor, Michigan: Institute for Social Research, University of Michigan; 2005.
dc.identifier.citedreferenceWu Q, Tchetgen EJ, Osypuk TL, White K, Mujahid M, Maria Glymour M. Combining direct and proxy assessments to reduce attrition bias in a longitudinal study. Alzheimer Dis Assoc Disord. 2013; 27 ( 3 ): 207 - 212. doi: 10.1097/WAD.0b013e31826cfe90
dc.identifier.citedreferenceWhitlock EL, Diaz-Ramirez LG, Smith AK, et al. Association of coronary artery bypass grafting vs percutaneous coronary intervention with memory decline in older adults undergoing coronary revascularization. JAMA. 2021; 325 ( 19 ): 1955 - 1964. doi: 10.1001/jama.2021.5150
dc.identifier.citedreferenceShaw JG, Farid M, Noel-Miller C, et al. Social isolation and medicare spending: among older adults, objective social isolation increases expenditures while loneliness does not. J Aging Health. 2017; 29 ( 7 ): 1119 - 1143. doi: 10.1177/0898264317703559
dc.identifier.citedreferencePeng S, Roth AR. Social isolation and loneliness before and during the covid-19 pandemic: a longitudinal study of US adults older than 50. J Gerontol B Psychol Sci Sco Sci. 2022; 77 ( 7 ): e185 - e190. doi: 10.1093/geronb/gbab068
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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