View Item 

Show simple item record

Comprehensive review: Frailty in pancreas transplant candidates and recipients
dc.contributor.authorParsons, Ronald F.
dc.contributor.authorTantisattamo, Ekamol
dc.contributor.authorCheungpasitporn, Wisit
dc.contributor.authorBasu, Arpita
dc.contributor.authorLu, Yee
dc.contributor.authorLentine, Krista L.
dc.contributor.authorWoodside, Kenneth J.
dc.contributor.authorSingh, Neeraj
dc.contributor.authorScalea, Joseph
dc.contributor.authorAlhamad, Tarek
dc.contributor.authorDunn, Ty B.
dc.contributor.authorRivera, Franco H. Cabeza
dc.contributor.authorParajuli, Sandesh
dc.contributor.authorPavlakis, Martha
dc.contributor.authorCooper, Matthew
dc.date.accessioned2023-03-03T21:10:36Z
dc.date.available2024-03-03 16:10:34en
dc.date.available2023-03-03T21:10:36Z
dc.date.issued2023-02
dc.identifier.citationParsons, Ronald F.; Tantisattamo, Ekamol; Cheungpasitporn, Wisit; Basu, Arpita; Lu, Yee; Lentine, Krista L.; Woodside, Kenneth J.; Singh, Neeraj; Scalea, Joseph; Alhamad, Tarek; Dunn, Ty B.; Rivera, Franco H. Cabeza; Parajuli, Sandesh; Pavlakis, Martha; Cooper, Matthew (2023). "Comprehensive review: Frailty in pancreas transplant candidates and recipients." Clinical Transplantation 37(2): n/a-n/a.
dc.identifier.issn0902-0063
dc.identifier.issn1399-0012
dc.identifier.urihttps://hdl.handle.net/2027.42/175932
dc.description.abstractWell-selected patients with kidney disease and diabetes mellitus who undergo simultaneous kidney-pancreas transplantation often experience dramatic improvements in quality of life and long-term survival compared to those who remain on medical therapy. Over the past several years the importance of frailty in the pancreas transplant candidate and recipient populations has grown. More patients with advanced age have entered the waitlist, and complications from prolonged diabetes, even in younger patients, have created increased evidence of risk for frailty. Given these concerns, and the broad challenges facing pancreas transplantation volumes overall, we generated this review to help establish the impact and implications. We summarize the interplay of immunological factors, aging, environmental factors, diabetes mellitus, and chronic kidney disease that put these patients at risk for frailty. We discuss its measurement and recommend a combination of two instruments (both well-validated and one entirely objective). We describe the outcomes for patients before and after pancreas transplantation who may have frailty, and what interventions can be taken to mitigate its effects. Broader investigation into frailty in the pancreas transplant population is needed to better understand how to select patients for pancreas transplantation and to how manage its consequences thereafter.
dc.publisherModern medicine Publishing Company
dc.publisherWiley Periodicals, Inc.
dc.subject.otherpancreas transplant alone
dc.subject.otherpancreas transplantation
dc.subject.othersimultaneous pancreas-kidney transplantation
dc.subject.othertype 1 diabetes mellitus
dc.subject.othertype 2 diabetes mellitus
dc.subject.otherpancreas after kidney transplantation
dc.subject.otherfrailty
dc.titleComprehensive review: Frailty in pancreas transplant candidates and recipients
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175932/1/ctr14899.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/175932/2/ctr14899_am.pdf
dc.identifier.doi10.1111/ctr.14899
dc.identifier.sourceClinical Transplantation
dc.identifier.citedreferenceFukuda Y, Asaoka T, Eguchi H, et al. Clinical impact of preoperative sarcopenia on the postoperative outcomes after pancreas transplantation. World J Surg. 2018; 42: 3364 - 3371.
dc.identifier.citedreferenceSheng K, Zhang P, Chen L, Cheng J, Wu C, Chen J. Intradialytic exercise in hemodialysis patients: a systematic review and meta-analysis. Am J Nephrol 2014; 40: 478 - 490.
dc.identifier.citedreferenceViña J, Rodriguez-Mañas L, Salvador-Pascual A, Tarazona-Santabalbina FJ, Gomez-Cabrera MC. Exercise: the lifelong supplement for healthy ageing and slowing down the onset of frailty. J Physiol 2016; 594: 1989 - 1999.
dc.identifier.citedreferenceVillareal DT, Aguirre L, Gurney AB, et al. Aerobic or resistance exercise, or both, in dieting obese older adults. N Engl J Med. 2017; 376: 1943 - 1955.
dc.identifier.citedreferenceThent ZC, Das S, Henry LJ. Role of exercise in the management of diabetes mellitus: the global scenario. PLoS ONE. 2013; 8: e80436.
dc.identifier.citedreferenceOstman C, Jewiss D, King N, Smart NA. Clinical outcomes to exercise training in type 1 diabetes: a systematic review and meta-analysis. Diab Res Clin Pract. 2018; 139: 380 - 391.
dc.identifier.citedreferenceQuirk H, Blake H, Tennyson R, Randell TL, Glazebrook C. Physical activity interventions in children and young people with type 1 diabetes mellitus: a systematic review with meta-analysis. Diab Med. 2014; 31: 1163 - 1173.
dc.identifier.citedreferenceYardley JE, Hay J, Abou-Setta AM, Marks SD, McGavock J. A systematic review and meta-analysis of exercise interventions in adults with type 1 diabetes. Diab Res Clin Pract. 2014; 106: 393 - 400.
dc.identifier.citedreferenceKennedy A, Nirantharakumar K, Chimen M, et al. Does exercise improve glycaemic control in type 1 diabetes? A systematic review and meta-analysis. PLoS ONE. 2013; 8: e58861.
dc.identifier.citedreferenceWu N, Bredin SSD, Guan Y, et al. Cardiovascular health benefits of exercise training in persons living with type 1 diabetes: a systematic review and meta-analysis. J Clin Med. 2019; 8 ( 2 ): 253. doi: 10.3390/jcm8020253
dc.identifier.citedreferenceKim DI, Lee DH, Hong S, Jo SW, Won YS, Jeon JY. Six weeks of combined aerobic and resistance exercise using outdoor exercise machines improves fitness, insulin resistance, and chemerin in the Korean elderly: a pilot randomized controlled trial. Arch Gerontol Geriatr. 2018; 75: 59 - 64.
dc.identifier.citedreferenceCadore EL, Izquierdo M. Exercise interventions in polypathological aging patients that coexist with diabetes mellitus: improving functional status and quality of life. Age (Dordr). 2015; 37: 64.
dc.identifier.citedreferenceMouch CA, Kenney BC, Lorch S, et al. Statewide prehabilitation program and episode payment in medicare beneficiaries. J Am Coll Surg. 2020; 230: 306 - 313.
dc.identifier.citedreferenceHoward R, Yin YS, McCandless L, Wang S, Englesbe M, Machado-Aranda D. Taking control of your surgery: impact of a prehabilitation program on major abdominal surgery. J Am Coll Surg. 2019; 228: 72 - 80.
dc.identifier.citedreferenceEnglesbe MJ, Grenda DR, Sullivan JA, et al. The Michigan surgical home and optimization program is a scalable model to improve care and reduce costs. Surgery. 2017; 161: 1659 - 1666.
dc.identifier.citedreferenceLuther A, Gabriel J, Watson RP, Francis NK. The impact of total body prehabilitation on post-operative outcomes after major abdominal surgery: a systematic review. World J Surg. 2018; 42: 2781 - 2791.
dc.identifier.citedreferenceStewart R. Cardiovascular disease and frailty: what are the mechanistic links? Clin Chem. 2019; 65: 80 - 86.
dc.identifier.citedreferenceBielecka-Dabrowa A, Ebner N, Dos Santos MR, Ishida J, Hasenfuss G, von Haehling S. Cachexia, muscle wasting, and frailty in cardiovascular disease. Eur J Heart Fail. 2020; 22: 2314 - 2326.
dc.identifier.citedreferenceSoysal P, Arik F, Smith L, Jackson SE, Isik AT. Inflammation, frailty and cardiovascular disease. Adv Exp Med Biol. 2020; 1216: 55 - 64.
dc.identifier.citedreferenceDibben GO, Dalal HM, Taylor RS, Doherty P, Tang LH, Hillsdon M. Cardiac rehabilitation and physical activity: systematic review and meta-analysis. Heart. 2018; 104: 1394 - 402.
dc.identifier.citedreferenceAnderson L, Oldridge N, Thompson DR, et al. Exercise-based cardiac rehabilitation for coronary heart disease: cochrane systematic review and meta-analysis. J Am Coll Cardiol. 2016; 67: 1 - 12.
dc.identifier.citedreferenceHoffman M, Chaves G, Ribeiro-Samora GA, Britto RR, Parreira VF. Effects of pulmonary rehabilitation in lung transplant candidates: a systematic review. BMJ Open. 2017; 7: e013445.
dc.identifier.citedreferenceGloeckl R, Schneeberger T, Jarosch I, Kenn K. Pulmonary rehabilitation and exercise training in chronic obstructive pulmonary disease. Dtsch Arztebl Int. 2018; 115: 117 - 123.
dc.identifier.citedreferenceFeng Z, Wang J, Xie Y, Li J. Effects of exercise-based pulmonary rehabilitation on adults with asthma: a systematic review and meta-analysis. Respir Res. 2021; 22: 33.
dc.identifier.citedreferenceHolland AE, Wadell K, Spruit MA. How to adapt the pulmonary rehabilitation programme to patients with chronic respiratory disease other than COPD. Eur Respir Rev. 2013; 22: 577 - 586.
dc.identifier.citedreferenceVon Oetinger A, Trujillo LM, Villanueva S, Zagolin M. Cardiopulmonary rehabilitation in pulmonary arterial hypertension. Rev Med Chil. 2018; 146: 627 - 635.
dc.identifier.citedreferenceCheng XS, Myers JN, Chertow GM, et al. Prehabilitation for kidney transplant candidates: is it time? Clin Transplant. 2017; 31 ( 8 ). doi: 10.1111/ctr.13020
dc.identifier.citedreferenceAl-Judaibi B, Alqalami I, Sey M, et al. Exercise training for liver transplant candidates. Transplant Proc. 2019; 51: 3330 - 3337.
dc.identifier.citedreferenceMcAdams-DeMarco MA, Isaacs K, Darko L, et al. Changes in frailty after kidney transplantation. J Am Geriatr Soc. 2015; 63: 2152 - 2157.
dc.identifier.citedreferencePainter PL, Hector L, Ray K, et al. A randomized trial of exercise training after renal transplantation. Transplantation. 2002; 74: 42 - 48.
dc.identifier.citedreferenceGreenwood SA, Koufaki P, Mercer TH, et al. Aerobic or resistance training and pulse wave velocity in kidney transplant recipients: a 12-week pilot randomized controlled trial (the exercise in renal transplant [ExeRT] trial). Am J Kidney Dis. 2015; 66: 689 - 698.
dc.identifier.citedreferenceRedmon JB, Kubo SH, Robertson RP. Glucose, insulin, and glucagon levels during exercise in pancreas transplant recipients. Diab Care 1995; 18: 457 - 462.
dc.identifier.citedreferenceCashion AK, Holmes SL, Hathaway DK, Gaber AO. Gastroparesis following kidney/pancreas transplant. Clin Transplant. 2004; 18: 306 - 311.
dc.identifier.citedreferencePatel N, Perez C, Taber DJ, Kalbavi V, Gonzales H, Rohan V. Safety and efficacy of perioperative sublingual tacrolimus in pancreas transplant compared with oral tacrolimus. Exp Clin Transplant. 2021; 19: 592 - 595.
dc.identifier.citedreferenceCerise A, Chen JM, Powelson JA, Lutz AJ, Fridell JA. Pancreas transplantation would be easy if the recipients were not diabetic: a practical guide to post-operative management of diabetic complications in pancreas transplant recipients. Clin Transplant. 2021; 35: e14270.
dc.identifier.citedreferenceFinlay S, Asderakis A, Ilham A, Elker D, Chapman D, Ablorsu E. The role of nutritional assessment and early enteral nutrition for combined pancreas and kidney transplant candidates. Clin Nutr ESPEN. 2017; 17: 22 - 27.
dc.identifier.citedreferenceBraga M, Castoldi R, Cristallo M, Valeri R, Pozza G, Di Carlo V. Catabolic response and parenteral nutrition after simultaneous kidney-pancreas transplantation. Nutrition. 1992; 8: 232 - 236.
dc.identifier.citedreferenceErgin AB, Poggio E, Krishnamurthi V, Jaber T, Hatipoglu BA. DPP-4 inhibitor therapy in patients after pancreatic transplant. Endocr Pract. 2015; 21: 567 - 573.
dc.identifier.citedreferenceClegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013; 381: 752 - 762.
dc.identifier.citedreferenceEnglesbe MJ, Patel SP, He K, et al. Sarcopenia and mortality after liver transplantation. J Am Coll Surg. 2010; 211: 271 - 278.
dc.identifier.citedreferenceKobashigawa J, Dadhania D, Bhorade S, et al. Report from the American Society of Transplantation on frailty in solid organ transplantation. Am J Transplant. 2019; 19: 984 - 994.
dc.identifier.citedreferenceHaugen CE, Thomas AG, Chu NM, et al. Prevalence of frailty among kidney transplant candidates and recipients in the United States: estimates from a National Registry and Multicenter Cohort Study. Am J Transplant. 2020; 20: 1170 - 1180.
dc.identifier.citedreferenceStenvinkel P, Carrero JJ, von Walden F, Ikizler TA, Nader GA. Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies. Nephrol Dial Transplant. 2016; 31: 1070 - 1077.
dc.identifier.citedreferenceLentine KL, Alhamad T, Cheungpasitporn W, et al. Impact of functional status on outcomes of simultaneous pancreas-kidney transplantation: risks and opportunities for patient benefit. Transplant Direct. 2020; 6: e599.
dc.identifier.citedreferenceCoresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007; 298: 2038 - 2047.
dc.identifier.citedreferenceCheca-Lopez M, Oviedo-Briones M, Pardo-Gomez A, et al. FRAILTOOLS study protocol: a comprehensive validation of frailty assessment tools to screen and diagnose frailty in different clinical and social settings and to provide instruments for integrated care in older adults. BMC Geriatr. 2019; 19: 86.
dc.identifier.citedreferenceVolpato S, Cavalieri M, Guerra G, et al. Performance-based functional assessment in older hospitalized patients: feasibility and clinical correlates. J Gerontol A Biol Sci Med Sci. 2008; 63: 1393 - 1398.
dc.identifier.citedreferenceNastasi AJ, McAdams-DeMarco MA, Schrack J, et al. Pre-kidney transplant lower extremity impairment and post-kidney transplant mortality. Am J Transplant. 2018; 18: 189 - 196.
dc.identifier.citedreferenceGruessner AC, Gruessner RW. Pancreas transplantation of US and non-US cases from 2005 to 2014 as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR). Rev Diabet Stud. 2016; 13: 35 - 58.
dc.identifier.citedreferenceKukla A, Ventura-Aguiar P, Cooper M, et al. Transplant options for patients with diabetes and advanced kidney disease: a review. Am J Kidney Dis. 2021; 78: 418 - 428.
dc.identifier.citedreferenceClark CM, Jr., Lee DA. Prevention and treatment of the complications of diabetes mellitus. N Engl J Med. 1995; 332: 1210 - 1217.
dc.identifier.citedreferenceBoggi U, Rosati CM, Marchetti P. Follow-up of secondary diabetic complications after pancreas transplantation. Curr Opin Organ Transplant. 2013; 18: 102 - 110.
dc.identifier.citedreferenceKhairoun M, de Koning EJ, van den Berg BM, et al. Microvascular damage in type 1 diabetic patients is reversed in the first year after simultaneous pancreas-kidney transplantation. Am J Transplant. 2013; 13: 1272 - 1281.
dc.identifier.citedreferenceKandaswamy R, Stock PG, Miller J, et al. OPTN/SRTR 2020 annual data report: pancreas. Am J Transplant. 2022; 22 (Suppl. 2 ): 137 - 203.
dc.identifier.citedreferenceKniepeiss D, Wagner D, Pienaar S, et al. Solid organ transplantation: technical progress meets human dignity: a review of the literature considering elderly patients’ health related quality of life following transplantation. Ageing Res Rev. 2012; 11: 181 - 187.
dc.identifier.citedreferenceKandaswamy R, Stock PG, Miller J, et al. OPTN/SRTR 2019 annual data report: pancreas. Am J Transplant. 2021; 21 (Suppl 2 ): 138 - 207.
dc.identifier.citedreferenceKandaswamy R, Stock PG, Gustafson SK, et al. OPTN/SRTR 2018 annual data report: pancreas. Am J Transplant. 2020; 20 (Suppl s1 ): 131 - 192.
dc.identifier.citedreferenceMcAdams-DeMarco MA, Ying H, Van Pilsum Rasmussen S, et al. Prehabilitation prior to kidney transplantation: results from a pilot study. Clin Transplant. 2019; 33: e13450.
dc.identifier.citedreferenceMaratova K, Soucek O, Matyskova J, et al. Muscle functions and bone strength are impaired in adolescents with type 1 diabetes. Bone. 2018; 106: 22 - 27.
dc.identifier.citedreferenceKhosla S, Samakkarnthai P, Monroe DG, Farr JN. Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus. Nat Rev Endocrinol. 2021; 17: 685 - 697.
dc.identifier.citedreferenceReese PP, Bloom RD, Shults J, et al. Functional status and survival after kidney transplantation. Transplantation. 2014; 97: 189 - 195.
dc.identifier.citedreferenceMcAdams-DeMarco MA, Ying H, Olorundare I, et al. Individual frailty components and mortality in kidney transplant recipients. Transplantation. 2017; 101: 2126 - 2132.
dc.identifier.citedreferenceAtkinson MA. The pathogenesis and natural history of type 1 diabetes. Cold Spring Harb Perspect Med. 2012; 2: a007641.
dc.identifier.citedreferenceAtkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet. 2001; 358: 221 - 229.
dc.identifier.citedreferenceBrunova J, Kratochvilova S, Stepankova J. Osteoporosis Therapy With Denosumab in Organ Transplant Recipients. Front Endocrinol (Lausanne) 2018; 9: 162.
dc.identifier.citedreferenceTsalamandris S, Antonopoulos AS, Oikonomou E, et al. The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol. 2019; 14: 50 - 59.
dc.identifier.citedreferenceLiu NF, Brown AS, Folias AE, et al. Stigma in people with type 1 or type 2 diabetes. Clin Diabetes. 2017; 35: 27 - 34.
dc.identifier.citedreferenceChao CT, Wang J, Huang JW, Chan DC, Chien KL. Frailty predicts an increased risk of end-stage renal disease with risk competition by mortality among 165,461 diabetic kidney disease patients. Aging Dis. 2019; 10: 1270 - 1281.
dc.identifier.citedreferenceHarhay MN, Rao MK, Woodside KJ, et al. An overview of frailty in kidney transplantation: measurement, management and future considerations. Nephrol Dial Transplant. 2020; 35: 1099 - 1112.
dc.identifier.citedreferenceMori H, Kuroda A, Araki M, et al. Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes. J Diabetes Investig. 2017; 8: 377 - 382.
dc.identifier.citedreferenceMayeda ER, Whitmer RA, Yaffe K. Diabetes and cognition. Clin Geriatr Med. 2015; 31: 101 - 115.
dc.identifier.citedreferenceBrigola AG, Rossetti ES, Dos Santos BR, et al. Relationship between cognition and frailty in elderly: a systematic review. Dement Neuropsychol. 2015; 9: 110 - 119.
dc.identifier.citedreferenceMoheet A, Mangia S, Seaquist ER. Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci. 2015; 1353: 60 - 71.
dc.identifier.citedreferenceTonoli C, Heyman E, Roelands B, et al. Type 1 diabetes-associated cognitive decline: a meta-analysis and update of the current literature. J Diab. 2014; 6: 499 - 513.
dc.identifier.citedreferenceChaytor NS, Riddlesworth TD, Bzdick S, et al. The relationship between neuropsychological assessment, numeracy, and functional status in older adults with type 1 diabetes. Neuropsychol Rehabil. 2017; 27: 507 - 521.
dc.identifier.citedreferenceAndreou A, Lasithiotakis K, Venianaki M, et al. A comparison of two preoperative frailty models in predicting postoperative outcomes in geriatric general surgical patients. World J Surg. 2018; 42: 3897 - 3902.
dc.identifier.citedreferenceMorley JE, Malmstrom TK, Rodriguez-Mañas L, Sinclair AJ. Frailty, sarcopenia and diabetes. J Am Med Dir Assoc. 2014; 15: 853 - 859.
dc.identifier.citedreferenceGarcia-Esquinas E, Graciani A, Guallar-Castillon P, Lopez-Garcia E, Rodriguez-Manas L, Rodriguez-Artalejo F. Diabetes and risk of frailty and its potential mechanisms: a prospective cohort study of older adults. J Am Med Dir Assoc. 2015; 16: 748 - 754.
dc.identifier.citedreferenceGuzik TJ, Cosentino F. Epigenetics and immunometabolism in diabetes and aging. Antioxid Redox Signal. 2018; 29: 257 - 274.
dc.identifier.citedreferenceHotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature. 2017; 542: 177 - 185.
dc.identifier.citedreferenceShapiro H, Lutaty A, Ariel A. Macrophages, meta-inflammation, and immuno-metabolism. Sci World J. 2011; 11: 2509 - 2529.
dc.identifier.citedreferenceKotas ME, Medzhitov R. Homeostasis, inflammation, and disease susceptibility. Cell. 2015; 160: 816 - 827.
dc.identifier.citedreferenceHotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 1996; 271: 665 - 668.
dc.identifier.citedreferenceWeisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW, Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112: 1796 - 1808.
dc.identifier.citedreferenceEhses JA, Perren A, Eppler E, et al. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes. 2007; 56: 2356 - 2370.
dc.identifier.citedreferenceAstrup A, Finer N. Redefining type 2 diabetes: ‘diabesity’ or ‘obesity dependent diabetes mellitus’? Obes Rev. 2000; 1: 57 - 59.
dc.identifier.citedreferenceTuttle LJ, Bittel DC, Bittel AJ, Sinacore DR. Early-onset physical frailty in adults with diabesity and peripheral neuropathy. Can J Diab. 2018; 42: 478 - 483.
dc.identifier.citedreferenceOwen RV, Thompson ER, Tingle SJ, et al. Too fat for transplant? The impact of recipient BMI on pancreas transplant outcomes. Transplantation. 2021; 105: 905 - 915.
dc.identifier.citedreferencePham PH, Stalter LN, Martinez EJ, et al. Single center results of simultaneous pancreas-kidney transplantation in patients with type 2 diabetes. Am J Transplant. 2021; 21: 2810 - 2823.
dc.identifier.citedreferenceFerrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018; 15: 505 - 522.
dc.identifier.citedreferenceFranceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018; 14: 576 - 590.
dc.identifier.citedreferenceMiki C, Kusunoki M, Inoue Y, et al. Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation. Surg Today. 2008; 38: 873 - 878.
dc.identifier.citedreferenceStrowig T, Henao-Mejia J, Elinav E, Flavell R. Inflammasomes in health and disease. Nature. 2012; 481: 278 - 286.
dc.identifier.citedreferenceTriantafilou M, Hughes TR, Morgan BP, Triantafilou K. Complementing the inflammasome. Immunology. 2016; 147: 152 - 164.
dc.identifier.citedreferencePrattichizzo F, Giuliani A, Recchioni R, et al. Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells. Oncotarget. 2016; 7: 11945 - 11958.
dc.identifier.citedreferenceSinclair AJ, Abdelhafiz AH, Rodríguez-Mañas L. Frailty and sarcopenia - newly emerging and high impact complications of diabetes. J Diab Comp. 2017; 31: 1465 - 1473.
dc.identifier.citedreferenceJang HC. Sarcopenia, frailty, and diabetes in older adults. Diab Metab J. 2016; 40: 182 - 9.
dc.identifier.citedreferenceLarsson L, Degens H, Li M, et al. Sarcopenia: aging-related loss of muscle mass and function. Physiol Rev. 2019; 99: 427 - 511.
dc.identifier.citedreferenceDodds R, Sayer AA. Sarcopenia and frailty: new challenges for clinical practice. Clin Med (Lond). 2016; 16: 455 - 8.
dc.identifier.citedreferenceTrierweiler H, Kisielewicz G, Hoffmann Jonasson T, Rasmussen Petterle R, Aguiar Moreira C, Zeghbi Cochenski Borba V. Sarcopenia: a chronic complication of type 2 diabetes mellitus. Diabetol Metab Syndr. 2018; 10: 25.
dc.identifier.citedreferenceYarbro JR, Emmons RS, Pence BD. Macrophage immunometabolism and inflammaging: roles of mitochondrial dysfunction, cellular senescence, CD38, and NAD. Immunometabolism. 2020; 2: e200026.
dc.identifier.citedreferenceEndemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol: JASN. 2004; 15: 1983 - 1992.
dc.identifier.citedreferenceAlonso-Bouzon C, Carcaillon L, Garcia-Garcia FJ, Amor-Andres MS, El Assar M, Rodriguez-Manas L. Association between endothelial dysfunction and frailty: the Toledo Study for Healthy Aging. Age (Dordr). 2014; 36: 495 - 505.
dc.identifier.citedreferenceZiaja J, Kowalik AP, Kolonko A, et al. Type 1 diabetic patients have better endothelial function after simultaneous pancreas-kidney transplantation than after kidney transplantation with continued insulin therapy. Diab Vasc Dis Res. 2018; 15: 122 - 130.
dc.identifier.citedreferenceBiesenbach G, Königsrainer A, Gross C, Margreiter R. Progression of macrovascular diseases is reduced in type 1 diabetic patients after more than 5 years successful combined pancreas-kidney transplantation in comparison to kidney transplantation alone. Transp Int. 2005; 18: 1054 - 1060.
dc.identifier.citedreferencePieralice S, Pozzilli P. Latent autoimmune diabetes in adults: a review on clinical implications and management. Diab Metab J. 2018; 42: 451 - 64.
dc.identifier.citedreferenceBuzzetti R, Zampetti S, Maddaloni E. Adult-onset autoimmune diabetes: current knowledge and implications for management. Nat Rev Endocrinol. 2017; 13: 674 - 686.
dc.identifier.citedreferenceCosentino A, Gambelunghe G, Tortoioli C, Falorni A. CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults. Ann N Y Acad Sci. 2002; 958: 337 - 340.
dc.identifier.citedreferenceHaller K, Kisand K, Pisarev H, et al. Insulin gene VNTR, CTLA-4 +49A/G and HLA-DQB1 alleles distinguish latent autoimmune diabetes in adults from type 1 diabetes and from type 2 diabetes group. Tissue Antigens. 2007; 69: 121 - 127.
dc.identifier.citedreferenceTiberti C, Giordano C, Locatelli M, et al. Identification of tyrosine phosphatase 2(256-760) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients: the non-insulin requiring autoimmune diabetes (NIRAD) study 2. Diabetes. 2008; 57: 1276 - 1283.
dc.identifier.citedreferenceBuzzetti R, Di Pietro S, Giaccari A, et al. High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes. Diab Care. 2007; 30: 932 - 938.
dc.identifier.citedreferenceOfori-Asenso R, Chin KL, Mazidi M, et al. Global incidence of frailty and prefrailty among community-dwelling older adults: a systematic review and meta-analysis. JAMA Netw Open. 2019; 2: e198398.
dc.identifier.citedreferenceShinall MC, Jr, Arya S, Youk A, et al. Association of preoperative patient frailty and operative stress with postoperative mortality. JAMA Surg. 2020; 155: e194620 - e.
dc.identifier.citedreferenceGaronzik-Wang JM, Govindan P, Grinnan JW, et al. Frailty and delayed graft function in kidney transplant recipients. Arch Surg. 2012; 147: 190 - 193.
dc.identifier.citedreferenceBasu A. Role of physical performance assessments and need for a standardized protocol for selection of older kidney transplant candidates. Kidney Int Rep 2019; 4: 1666 - 1676.
dc.identifier.citedreferenceWalston J, Buta B, Xue QL. Frailty screening and interventions: considerations for clinical practice. Clin Geriatr Med. 2018; 34: 25 - 38.
dc.identifier.citedreferenceMcAdams-DeMarco MA, Van Pilsum Rasmussen SE, Chu NM, et al. Perceptions and practices regarding frailty in kidney transplantation: results of a national survey. Transplantation. 2020; 104: 349 - 356.
dc.identifier.citedreferenceStedman MR, Watford DJ, Chertow GM, Tan JC. Karnofsky performance score-failure to thrive as a frailty proxy? Transplant Direct. 2021; 7: e708.
dc.identifier.citedreferenceSalter ML, Gupta N, Massie AB, et al. Perceived frailty and measured frailty among adults undergoing hemodialysis: a cross-sectional analysis. BMC Geriatr. 2015; 15: 52.
dc.identifier.citedreferenceForti P, Maioli F, Lega MV, Montanari L, Coraini F, Zoli M. Combination of the clock drawing test with the physical phenotype of frailty for the prediction of mortality and other adverse outcomes in older community dwellers without dementia. Gerontology. 2014; 60: 204 - 211.
dc.identifier.citedreferenceChen X, Shafaat O, Liu Y, et al. Revision of frailty assessment in kidney transplant recipients: replacing unintentional weight loss with CT-assessed sarcopenia in the physical frailty phenotype. Am J Transplant. 2022; 22: 1145 - 1157.
dc.identifier.citedreferenceChoinski K, Rocca JP, Torabi J, et al. The pancreas can take the cold: lower waitlist times through importation. Transplant Proc. 2017; 49: 2305 - 2309.
dc.identifier.citedreferenceStites E, Wiseman AC. Live donor kidney - PAK versus SPK: how to decide? Curr Opin Organ Transplant. 2017; 22: 377 - 381.
dc.identifier.citedreferenceAhmadi SF, Streja E, Zahmatkesh G, et al. Reverse epidemiology of traditional cardiovascular risk factors in the geriatric population. J Am Med Dir Assoc. 2015; 16: 933 - 939.
dc.identifier.citedreferenceAl Snih S, Ottenbacher KJ, Markides KS, Kuo YF, Eschbach K, Goodwin JS. The effect of obesity on disability vs mortality in older Americans. Arch Intern Med. 2007; 167: 774 - 780.
dc.identifier.citedreferenceBlaum CS, Xue QL, Michelon E, Semba RD, Fried LP. The association between obesity and the frailty syndrome in older women: the Women’s Health and Aging Studies. J Am Geriatr Soc. 2005; 53: 927 - 934.
dc.identifier.citedreferenceLohman MC, Resciniti NV, Wirth MD, Shivappa N, Hebert JR. Obesity, dietary inflammation, and frailty among older adults: evidence from the national health and nutrition examination survey. J Nutr Gerontol Geriatr. 2019; 38: 18 - 32.
dc.identifier.citedreferenceWalston J, McBurnie MA, Newman A, et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002; 162: 2333 - 2341.
dc.identifier.citedreferenceChrysohoou C, Panagiotakos DB, Pitsavos C, et al. The implication of obesity on total antioxidant capacity in apparently healthy men and women: the ATTICA study. Nutr Metab Cardiovasc Dis. 2007; 17: 590 - 597.
dc.identifier.citedreferenceBaumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998; 147: 755 - 763.
dc.identifier.citedreferenceBaumgartner RN. Body composition in healthy aging. Ann N Y Acad Sci. 2000; 904: 437 - 448.
dc.identifier.citedreferenceTantisattamo E, Kalantar-Zadeh K, Halleck F, Duettmann W, Naik M, Budde K. Novel approaches to sarcopenic obesity and weight management before and after kidney transplantation. Curr Opin Nephrol Hypertens. 2021; 30: 14 - 26.
dc.identifier.citedreferenceHaugen CE, Chu NM, Ying H, et al. Frailty and access to kidney transplantation. Clin J Am Soc Nephrol. 2019; 14: 576 - 582.
dc.identifier.citedreferenceFedarko NS. The biology of aging and frailty. Clin Geriatr Med. 2011; 27: 27 - 37.
dc.identifier.citedreferenceSanada F, Taniyama Y, Muratsu J, et al. Source of chronic inflammation in aging. Front Cardiovasc Med. 2018; 5: 12.
dc.identifier.citedreferenceKim JC, Kalantar-Zadeh K, Kopple JD. Frailty and protein-energy wasting in elderly patients with end stage kidney disease. J Am Soc Nephrol: JASN. 2013; 24: 337 - 351.
dc.identifier.citedreferenceParkman HP, Yates KP, Hasler WL, et al. Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesis. Gastroenterology. 2011; 141: 486 - 498.
dc.identifier.citedreferencePiper MS, Saad RJ. Diabetes mellitus and the colon. Curr Treat Options Gastroenterol. 2017; 15: 460 - 474.
dc.identifier.citedreferenceHorvath VJ, Putz Z, Izbeki F, et al. Diabetes-related dysfunction of the small intestine and the colon: focus on motility. Curr Diab Rep. 2015; 15: 94.
dc.identifier.citedreferenceFaussone-Pellegrini MS, Grover M, Pasricha PJ, et al. Ultrastructural differences between diabetic and idiopathic gastroparesis. J Cell Mol Med. 2012; 16: 1573 - 1581.
dc.identifier.citedreferenceKuznik E, Dudkowiak R, Adamiec R, Poniewierka E. Diabetic autonomic neuropathy of the gastrointestinal tract. Prz Gastroenterol. 2020; 15: 89 - 93.
dc.identifier.citedreferenceAmjad W, Qureshi W, Singh RR, Richter S. Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis. Ann Gastroenterol. 2021; 34: 788 - 795.
dc.identifier.citedreferencePrado CM, Ford KL, Gonzalez MC, et al. Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient. JPEN J Parenter Enteral Nutr. 2022; 1 - 15. doi: 10.1002/jpen.2420
dc.identifier.citedreferenceDetsky AS, Baker J, Johnston N, Whittaker S, Mendelson R, Jeejeebhoy K. What is subjective global assessment of nutritional status? J Parent Enteral Nutr. 1987; 11: 8 - 13.
dc.identifier.citedreferenceIglesias ML, Koll F, Delfante A, Sun Ho H, Grosembacher L, Rodota L. Nutritional assessment of patients candidates for waiting list simultaneous kidney pancreas transplantation. Nutr Hosp. 2010; 25: 406 - 413.
dc.identifier.citedreferenceSchenker P, Vonend O, Krüger B, et al. Long-term results of pancreas transplantation in patients older than 50 years. Transp Int. 2011; 24: 136 - 142.
dc.identifier.citedreferenceMittal S, Smilevska R, Franklin R, et al. An analysis of the association between older recipient age and outcomes after whole-organ pancreas transplantation - a single-centre, retrospective study. Transpl Int. 2020; 33: 529 - 535.
dc.identifier.citedreferenceMontagud-Marrahi E, Molina-Andújar A, Pané A, et al. Outcomes of pancreas transplantation in older diabetic patients. BMJ Open Diabetes Res Car. 2020; 8: e000916. doi: 10.1136/bmjdrc-2019-000916
dc.identifier.citedreferenceScalea JR, Redfield RR, 3rd, Arpali E, et al. Pancreas transplantation in older patients is safe, but patient selection is paramount. Transpl Int. 2016; 29: 810 - 8.
dc.identifier.citedreferenceSiskind E, Maloney C, Akerman M, et al. An analysis of pancreas transplantation outcomes based on age groupings–an update of the UNOS database. Clin Transplant. 2014; 28: 990 - 4.
dc.identifier.citedreferenceShah AP, Mangus RS, Powelson JA, et al. Impact of recipient age on whole organ pancreas transplantation. Clin Transplant. 2013; 27: E49 - E55.
dc.identifier.citedreferenceAblorsu E, Ghazanfar A, Mehra S, et al. Outcome of pancreas transplantation in recipients older than 50 years: a single-centre experience. Transplantation. 2008; 86: 1511 - 154.
dc.identifier.citedreferenceFoley DP, Patton PR, Meier-Kriesche HU, et al. Long-term outcomes of kidney transplantation in recipients 60 years of age and older at the University of Florida. Clin Transpl. 2005; 19: 101 - 109.
dc.identifier.citedreferenceFreise CE, Stock PG, Melzer JS. Increased morbidity and mortality of simultaneous pancreas-renal transplantation in patients over 49 years of age. Transplant Proc. 1998; 30: 292.
dc.identifier.citedreferenceMeier RP, Noguchi H, Kelly YM, et al. Impact of sarcopenia on simultaneous pancreas and kidney transplantation outcomes: a retrospective observational cohort study. Transpl Direct. 2020; 6: e610.
dc.identifier.citedreferenceParsons R, Wolosyn J, Lynch R. Morphometric and metabolic correlates of frailty in pancreas transplant recipients. Am J Transpl. 2018; 18 ( S4 ): 432.
dc.identifier.citedreferenceNoguchi H, Miyasaka Y, Kaku K, et al. Preoperative muscle volume predicts graft survival after pancreas transplantation: a retrospective observational cohort study. Transplant Proc. 2018; 50: 1482 - 1488.
dc.identifier.citedreferenceParajuli S, Aziz F, Garg N, et al. Frailty in pancreas transplantation. Transplantation. 2021; 105: 1685 - 1694.
dc.identifier.citedreferenceBozek-Pajak D, Ziaja J, Kowalik A, et al. Past cardiovascular episodes deteriorate quality of life of patients with type 1 diabetes and end-stage kidney disease after kidney or simultaneous pancreas and kidney transplantation. Transplant Proc. 2016; 48: 1667 - 1672.
dc.identifier.citedreferenceZiaja J, Bozek-Pajak D, Kowalik A, Krol R, Cierpka L. Impact of pancreas transplantation on the quality of life of diabetic renal transplant recipients. Transplant Proc. 2009; 41: 3156 - 3158.
dc.identifier.citedreferencePosegger KR, Linhares MM, Mucci S, et al. The quality of life in type I diabetic patients with end-stage kidney disease before and after simultaneous pancreas-kidney transplantation: a single-center prospective study. Transpl Int. 2020; 33: 330 - 339.
dc.identifier.citedreferenceSinclair AJ, Rodriguez-Mañas L. Diabetes and frailty: two converging conditions? Can J Diab. 2016; 40: 77 - 83.
dc.identifier.citedreferenceChu NM, Deng A, Ying H, et al. Dynamic frailty before kidney transplantation: time of measurement matters. Transplantation. 2019; 103: 1700 - 1704.
dc.identifier.citedreferenceDunn TB. Life after pancreas transplantation: reversal of diabetic lesions. Curr Opin Organ Transplant. 2014; 19: 73 - 79.
dc.identifier.citedreferenceJanaudis-Ferreira T, Mathur S, Deliva R, et al. Exercise for solid organ transplant candidates and recipients: a joint position statement of the Canadian society of transplantation and can-restore. Transplantation. 2019; 103: e220 - e238.
dc.identifier.citedreferenceKellogg JH. The value of strength tests in the prescription of exercise. Modern medicine Publishing Company; 1896.
dc.identifier.citedreferenceMcDermott MM. Exercise training for intermittent claudication. J Vasc Surg 2017; 66: 1612 - 1620.
dc.identifier.citedreferenceDua A, Gologorsky R, Savage D, et al. National assessment of availability, awareness, and utilization of supervised exercise therapy for peripheral artery disease patients with intermittent claudication. J Vasc Surg 2020; 71: 1702 - 1707.
dc.identifier.citedreferenceSheshadri A, Kittiskulnam P, Lazar AA, Johansen KL. A walking intervention to increase weekly steps in dialysis patients: a pilot randomized controlled trial. Am J Kidney Dis. 2020; 75: 488 - 496.
dc.identifier.citedreferenceSuhardjono, Umami V, Tedjasukmana D, Setiati S. The effect of intradialytic exercise twice a week on the physical capacity, inflammation, and nutritional status of dialysis patients: a randomized controlled trial. Hemodial Int. 2019; 23: 486 - 493.
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
ctr14899.pdf
Size:
938.5KB
Format:
PDF
View/Open
Name:
ctr14899_am.pdf
Size:
1.689MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.