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Effect of laser-assisted reconstructive surgical therapy of peri-implantitis on protein biomarkers and bacterial load
dc.contributor.authorDi gianfilippo, Riccardo
dc.contributor.authorWang, Chin-Wei
dc.contributor.authorXie, Yuying
dc.contributor.authorKinney, Janet
dc.contributor.authorSugai, James
dc.contributor.authorGiannobile, William V.
dc.contributor.authorWang, Hom-Lay
dc.date.accessioned2023-05-01T19:13:00Z
dc.date.available2024-05-01 15:12:59en
dc.date.available2023-05-01T19:13:00Z
dc.date.issued2023-04
dc.identifier.citationDi gianfilippo, Riccardo ; Wang, Chin-Wei ; Xie, Yuying; Kinney, Janet; Sugai, James; Giannobile, William V.; Wang, Hom-Lay (2023). "Effect of laser- assisted reconstructive surgical therapy of peri- implantitis on protein biomarkers and bacterial load." Clinical Oral Implants Research (4): 393-403.
dc.identifier.issn0905-7161
dc.identifier.issn1600-0501
dc.identifier.urihttps://hdl.handle.net/2027.42/176323
dc.description.abstractObjectivesThis randomized clinical trial assessed changes in protein biomarker levels and bacterial profiles after surgical reconstructive therapy of peri-implantitis and investigated whether the adjunctive use of Er:YAG laser impacts protein biomarker and microbial outcomes.Materials and MethodsTwenty-four patients received surgical reconstructive therapy for peri-implantitis with guided bone regeneration following mechanical debridement with (test) or without (control) the adjunctive irradiation of Er:YAG laser. Bacterial and peri-implant crevicular fluid (PICF) samples were collected over 6 months and analyzed with bacterial qPCR and luminex multiplex assays.ResultsSurgical reconstructive treatment significantly affected the concentration of PICF protein biomarkers, including a 50% reduction in IL-1β between 2 and 4 weeks (p < .0001). Both MMP-9 (p < .001) and VEGF (p < .05) levels steadily decreased after treatment. In the laser group, the peak increase in IL-1β was attenuated at 2 weeks, followed by significant reduction in MMP-9 (p < .01) and VEGF (p < .05) across all follow-up appointments compared with the control nonlaser group. The total bacterial load was reduced 2 weeks after treatment, especially in the laser group, but recolonized to presurgical levels after 4 weeks in both groups (p < .01). The composition of selective pathogens varied significantly over the follow-up, but recolonization patterns did not differ between groups.ConclusionsReconstructive therapy of peri-implantitis significantly altered PICF protein biomarker and microbial levels during the healing process. The adjunctive use of Er:YAG laser significantly modulated the inflammatory response through reduced levels of MMP-9 and VEGF during the postsurgical period. The bacterial load was reduced immediately after therapy, but recolonization was observed by 4 weeks in both groups.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherperiodontology
dc.subject.otherwound healing
dc.subject.otherlasers
dc.subject.otherguided tissue regeneration, bone regeneration
dc.subject.otherbone regeneration, clinical trials
dc.subject.otherbone implant interactions
dc.subject.othermicrobiology
dc.titleEffect of laser-assisted reconstructive surgical therapy of peri-implantitis on protein biomarkers and bacterial load
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/176323/1/clr14059.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/176323/2/clr14059_am.pdf
dc.identifier.doi10.1111/clr.14059
dc.identifier.sourceClinical Oral Implants Research
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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