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Baseline characterization of the ARMADA (Assessing Reliable Measurement in Alzheimer’s Disease) study cohorts
dc.contributor.authorKarpouzian-Rogers, Tatiana
dc.contributor.authorHo, Emily
dc.contributor.authorNovack, Miriam
dc.contributor.authorChinkers, Miriam
dc.contributor.authorBedjeti, Katy
dc.contributor.authorNowinski, Cindy
dc.contributor.authorGiordani, Bruno
dc.contributor.authorGershon, Richard
dc.contributor.authorWeintraub, Sandra
dc.date.accessioned2023-06-01T20:51:31Z
dc.date.available2024-06-01 16:51:29en
dc.date.available2023-06-01T20:51:31Z
dc.date.issued2023-05
dc.identifier.citationKarpouzian-Rogers, Tatiana ; Ho, Emily; Novack, Miriam; Chinkers, Miriam; Bedjeti, Katy; Nowinski, Cindy; Giordani, Bruno; Gershon, Richard; Weintraub, Sandra (2023). "Baseline characterization of the ARMADA (Assessing Reliable Measurement in Alzheimer’s Disease) study cohorts." Alzheimer’s & Dementia 19(5): 1974-1982.
dc.identifier.issn1552-5260
dc.identifier.issn1552-5279
dc.identifier.urihttps://hdl.handle.net/2027.42/176883
dc.description.abstractIntroductionThe National Institutes of Health (NIH) Toolbox (NIHTB) provides computerized measures of cognition, emotion, sensation, and motor abilities across the lifespan. The ARMADA (Assessing Reliable Measurement in Alzheimer’s Disease and Cognitive Aging) study validated the NIHTB in individuals across the cognitive aging spectrum. This article reports the characteristics of our sample of participants.MethodsParticipants were recruited across nine sites and classified clinically as cognitively normal (NC), with mild cognitive impairment (MCI), or with dementia of the Alzheimer’s type (DAT.) They completed the NIHTB at multiple time points and many had at least one Alzheimer’s biomarker previously obtained.ResultsGroups differed with respect to dementia severity levels, as anticipated, but were well-matched across many demographic characteristics.DiscussionThe ARMADA study demographics and baseline characteristics provide a suitable sample for validating the NIHTB across the cognitive aging spectrum. Other enriched samples (African American participants, Spanish NIHTB, 85+ years of age) will be reported elsewhere.HighlightsThere is a need for assessments that can detect the early stages of cognitive decline in older adults.The ARMADA (Assessing Reliable Measurement in Alzheimer’s Disease and Cognitive Aging) study will validate the National Institutes of Health (NIH) Toolbox across the aging spectrum, including mild cognitive impairment (MCI) and dementia of the Alzheimer’s type (DAT).Here we report the characteristics of participants.Groups were well-matched across most demographic characteristics, and clinical characteristics differed as expected.ARMADA study cohorts reflect their respective clinical syndromes for validating the NIH Toolbox.
dc.publisherWiley Periodicals, Inc.
dc.publisherOxford University Press
dc.subject.othercognition
dc.subject.othermild cognitive impairment
dc.subject.otherNIH Toolbox
dc.subject.otherdementia
dc.subject.otheraging
dc.subject.otherAlzheimer’s disease
dc.titleBaseline characterization of the ARMADA (Assessing Reliable Measurement in Alzheimer’s Disease) study cohorts
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurology and Neurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/176883/1/alz12816.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/176883/2/alz12816_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/176883/3/alz12816-sup-0002-ICMJE.pdf
dc.identifier.doi10.1002/alz.12816
dc.identifier.sourceAlzheimer’s & Dementia
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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