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Diversity of cells and signals in the cardiovascular system
dc.contributor.authorGrandi, Eleonora
dc.contributor.authorNavedo, Manuel F.
dc.contributor.authorSaucerman, Jeffrey J.
dc.contributor.authorBers, Donald M.
dc.contributor.authorChiamvimonvat, Nipavan
dc.contributor.authorDixon, Rose E.
dc.contributor.authorDobrev, Dobromir
dc.contributor.authorGomez, Ana M.
dc.contributor.authorHarraz, Osama F.
dc.contributor.authorHegyi, Bence
dc.contributor.authorJones, David K.
dc.contributor.authorKrogh-Madsen, Trine
dc.contributor.authorMurfee, Walter Lee
dc.contributor.authorNystoriak, Matthew A.
dc.contributor.authorPosnack, Nikki G.
dc.contributor.authorRipplinger, Crystal M.
dc.contributor.authorVeeraraghavan, Rengasayee
dc.contributor.authorWeinberg, Seth
dc.date.accessioned2023-07-14T13:58:22Z
dc.date.available2024-08-14 09:58:20en
dc.date.available2023-07-14T13:58:22Z
dc.date.issued2023-07
dc.identifier.citationGrandi, Eleonora; Navedo, Manuel F.; Saucerman, Jeffrey J.; Bers, Donald M.; Chiamvimonvat, Nipavan; Dixon, Rose E.; Dobrev, Dobromir; Gomez, Ana M.; Harraz, Osama F.; Hegyi, Bence; Jones, David K.; Krogh-Madsen, Trine ; Murfee, Walter Lee; Nystoriak, Matthew A.; Posnack, Nikki G.; Ripplinger, Crystal M.; Veeraraghavan, Rengasayee; Weinberg, Seth (2023). "Diversity of cells and signals in the cardiovascular system." The Journal of Physiology 601(13): 2547-2592.
dc.identifier.issn0022-3751
dc.identifier.issn1469-7793
dc.identifier.urihttps://hdl.handle.net/2027.42/177290
dc.description.abstractThis white paper is the outcome of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. This biannual meeting aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2022 Symposium was ‘Cell Diversity in the Cardiovascular System, cell-autonomous and cell–cell signalling’. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies, and challenges in examining cell and signal diversity, co-ordination and interrelationships involved in cardiovascular function. This paper originates from the topics of formal presentations and informal discussions from the Symposium, which aimed to develop a holistic view of how the multiple cell types in the cardiovascular system integrate to influence cardiovascular function, disease progression and therapeutic strategies. The first section describes the major cell types (e.g. cardiomyocytes, vascular smooth muscle and endothelial cells, fibroblasts, neurons, immune cells, etc.) and the signals involved in cardiovascular function. The second section emphasizes the complexity at the subcellular, cellular and system levels in the context of cardiovascular development, ageing and disease. Finally, the third section surveys the technological innovations that allow the interrogation of this diversity and advancing our understanding of the integrated cardiovascular function and dysfunction.Abstract figure legend This white paper discusses the cell diversity, co-ordination and interaction patterns that are critical for robust cardiovascular function. We identify the major cell types and signals involved in cardiovascular function and emphasize the complexity at the subcellular, cellular and system levels that motivate both challenges and opportunities for researchers. A survey of recent advances enabled by innovative experimental and computational modelling approaches serve to guide researchers moving forward.
dc.publisherWiley Periodicals, Inc.
dc.publisherIOP Publishing Ltd
dc.subject.othersignal transduction
dc.subject.otherion channels
dc.subject.otherion transporters
dc.subject.othermodelling
dc.subject.otheromics
dc.subject.otheranimal models
dc.titleDiversity of cells and signals in the cardiovascular system
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPhysiology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/177290/1/tjp15436_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/177290/2/tjp15436-sup-0001-PeerReview.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/177290/3/tjp15436.pdf
dc.identifier.doi10.1113/JP284011
dc.identifier.sourceThe Journal of Physiology
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