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Asymmetric synthesis of dihydroartemisinic acid through intramolecular Stetter reaction
dc.contributor.authorRej, RK
dc.contributor.authorAcharyya, RK
dc.contributor.authorNanda, S
dc.date.accessioned2023-09-13T13:10:15Z
dc.date.available2023-09-13T13:10:15Z
dc.date.issued2016-01-01
dc.identifier.issn0040-4020
dc.identifier.issn1464-5416
dc.identifier.urihttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000380604100021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=cc40378bfc9614a14500fbd6db90869f
dc.identifier.urihttps://hdl.handle.net/2027.42/177665en
dc.description.abstractA short and concise formal synthesis of enantiopure dihydroartemisinic acid from (R)-citronellal is described in this article. Intramolecular version of asymmetric Stetter reaction using Rovis aminoindane based NHC catalyst was explored to access the core substituted cyclohexanone framework which on functional group manipulation and late stage ring closing metathesis (RCM) reaction afforded an advanced intermediate for dihydroartemisinic acid.
dc.languageen
dc.publisherElsevier
dc.subjectAntimalarial compounds
dc.subjectAsymmetric synthesis
dc.subjectIntramolecular Stetter reaction
dc.subjectRing closing metathesis
dc.titleAsymmetric synthesis of dihydroartemisinic acid through intramolecular Stetter reaction
dc.typeArticle
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/177665/2/Asymmetric synthesis of dihydroartemisinic.pdf
dc.identifier.doi10.1016/j.tet.2016.06.066
dc.identifier.doihttps://dx.doi.org/10.7302/8122
dc.identifier.sourceTetrahedron
dc.description.versionPublished version
dc.date.updated2023-09-13T13:10:14Z
dc.identifier.orcid0000-0003-0904-9137
dc.identifier.volume72
dc.identifier.issue32
dc.identifier.startpage4931
dc.identifier.endpage4937
dc.identifier.name-orcidRej, RK; 0000-0003-0904-9137
dc.identifier.name-orcidAcharyya, RK
dc.identifier.name-orcidNanda, S
dc.working.doi10.7302/8122en
dc.owningcollnameInternal Medicine, Department of


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