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Chemoenzymatic asymmetric synthesis of fluoxetine, atomoxetine, nisoxetine, and duloxetine
dc.contributor.authorRej, RK
dc.contributor.authorDas, T
dc.contributor.authorHazra, S
dc.contributor.authorNanda, S
dc.date.accessioned2023-09-13T13:21:09Z
dc.date.available2023-09-13T13:21:09Z
dc.date.issued2013-08-31
dc.identifier.issn0957-4166
dc.identifier.issn1362-511X
dc.identifier.urihttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324457000006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=cc40378bfc9614a14500fbd6db90869f
dc.identifier.urihttps://hdl.handle.net/2027.42/177671en
dc.description.abstractThe asymmetric synthesis of two well-known anti-depressant drugs, fluoxetine and duloxetine has been accomplished in a chemoenzymatic manner. The main highlight of the synthesis is the enantioselective cyanohydrin formation by a plant (R)-HNL (hydroxynitrile lyase). The enantiopure cyanohydrins are then synthetically manipulated into the above two drug molecules and two of their structural analogues, atomoxetine and nisoxetine. © 2013 Elsevier Ltd. All rights reserved.
dc.languageen
dc.publisherElsevier
dc.titleChemoenzymatic asymmetric synthesis of fluoxetine, atomoxetine, nisoxetine, and duloxetine
dc.typeArticle
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/177671/2/Chemoenzymatic asymmetric synthesis of fluoxetine.pdf
dc.identifier.doi10.1016/j.tetasy.2013.06.003
dc.identifier.doihttps://dx.doi.org/10.7302/8128
dc.identifier.sourceTetrahedron Asymmetry
dc.description.versionPublished version
dc.date.updated2023-09-13T13:21:08Z
dc.identifier.orcid0000-0003-0904-9137
dc.identifier.volume24
dc.identifier.issue15-16
dc.identifier.startpage913
dc.identifier.endpage918
dc.identifier.name-orcidRej, RK; 0000-0003-0904-9137
dc.identifier.name-orcidDas, T
dc.identifier.name-orcidHazra, S
dc.identifier.name-orcidNanda, S
dc.working.doi10.7302/8128en
dc.owningcollnameInternal Medicine, Department of


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