Family environment and polygenic risk in the bipolar high-risk context.
dc.contributor.author | Stapp, Emma K | |
dc.contributor.author | Fullerton, Janice M | |
dc.contributor.author | Musci, Rashelle J | |
dc.contributor.author | Zandi, Peter P | |
dc.contributor.author | McInnis, Melvin G | |
dc.contributor.author | Mitchell, Philip B | |
dc.contributor.author | Hulvershorn, Leslie A | |
dc.contributor.author | Ghaziuddin, Neera | |
dc.contributor.author | Roberts, Gloria | |
dc.contributor.author | Ferrera, Alessandra G | |
dc.contributor.author | Nurnberger, John I | |
dc.contributor.author | Wilcox, Holly C | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2023-11-11T14:20:01Z | |
dc.date.available | 2023-11-11T14:20:01Z | |
dc.date.issued | 2023-06 | |
dc.identifier.issn | 2692-9384 | |
dc.identifier.issn | 2692-9384 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/37378048 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/191434 | en |
dc.description.abstract | BACKGROUND: The interaction of polygenic risk (PRS) and environmental effects on development of bipolar disorder (BD) is understudied, as are high-risk offspring perceptions of their family environment (FE). We tested the association of offspring-perceived FE in interaction with BD-PRS on liability for BD in offspring at high or low familial risk for BD. METHODS: Offspring of a parent with BD (oBD; n = 266) or no psychiatric disorders (n = 174), aged 12-21 at recruitment, participated in the US and Australia. Empirically-derived profiles of FE classified offspring by their perceived levels of familial cohesion, flexibility, and conflict. Offspring BD-PRS were derived from Psychiatric Genomics Consortium BD-GWAS. Lifetime DSM-IV bipolar disorders were derived from the Schedule for Affective Disorders and Schizophrenia for School-Aged Children. We used a novel stepwise approach for latent class modeling with predictors and distal outcomes. RESULTS: Fifty-two offspring were diagnosed with BD. For those with well-functioning FE (two-thirds of the sample), higher BD-PRS tracked positively with liability for BD. However, for those with high-conflict FEs, the relationship between BD-PRS and liability to BD was negative, with highest risk for BD observed with lower BD-PRS. In exploratory analyses, European-ancestry offspring with BD had elevated history of suicidal ideation in high-conflict FE compared to well-functioning-FE, and of suicide attempt with low-BD-PRS and high-conflict FE. CONCLUSIONS: The data suggest that the relationship of BD-PRS and offspring liability for BD differed between well-functioning versus high-conflict FE, potentially in line with a multifactorial liability threshold model and supporting future study of and interventions improving family dynamics. | |
dc.format.medium | Electronic-eCollection | |
dc.language | eng | |
dc.publisher | Wiley | |
dc.rights | Licence for published version: Creative Commons Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | attempted | |
dc.subject | bipolar disorder | |
dc.subject | gene‐environment interaction | |
dc.subject | multifactorial inheritance | |
dc.subject | parent‐child relations | |
dc.subject | suicide | |
dc.title | Family environment and polygenic risk in the bipolar high-risk context. | |
dc.type | Article | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/191434/2/Family environment and polygenic risk in the bipolar high-risk context.pdf | |
dc.identifier.doi | 10.1002/jcv2.12143 | |
dc.identifier.doi | https://dx.doi.org/10.7302/21720 | |
dc.identifier.source | JCPP Adv | |
dc.description.version | Published online | |
dc.date.updated | 2023-11-11T14:19:59Z | |
dc.identifier.orcid | 0000-0003-0628-0704 | |
dc.identifier.orcid | 0000-0002-0375-6247 | |
dc.identifier.orcid | 0000-0002-7381-3948 | |
dc.identifier.volume | 3 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | e12143 | |
dc.identifier.name-orcid | Stapp, Emma K; 0000-0003-0628-0704 | |
dc.identifier.name-orcid | Fullerton, Janice M | |
dc.identifier.name-orcid | Musci, Rashelle J | |
dc.identifier.name-orcid | Zandi, Peter P | |
dc.identifier.name-orcid | McInnis, Melvin G; 0000-0002-0375-6247 | |
dc.identifier.name-orcid | Mitchell, Philip B | |
dc.identifier.name-orcid | Hulvershorn, Leslie A | |
dc.identifier.name-orcid | Ghaziuddin, Neera; 0000-0002-7381-3948 | |
dc.identifier.name-orcid | Roberts, Gloria | |
dc.identifier.name-orcid | Ferrera, Alessandra G | |
dc.identifier.name-orcid | Nurnberger, John I | |
dc.identifier.name-orcid | Wilcox, Holly C | |
dc.working.doi | 10.7302/21720 | en |
dc.owningcollname | Psychiatry, Department of |
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