Ultrafast X-ray Absorption Spectroscopy Reveals Excited State Dynamics of B12 Coenzymes Controlled by the Axial Base
dc.contributor.author | Chung, Taewon | |
dc.contributor.author | McClain, Taylor P. | |
dc.contributor.author | Alonso-Mori, Roberto | |
dc.contributor.author | Chollet, Matthieu | |
dc.contributor.author | Deb, Aniruddha | |
dc.contributor.author | Garcia-Esparza, Angel T. | |
dc.contributor.author | Huang, Joel Ze En | |
dc.contributor.author | Lamb, Ryan M. | |
dc.contributor.author | Michocki, Lindsay B. | |
dc.contributor.author | Reinhard, Marco | |
dc.contributor.author | van Driel, Tim B. | |
dc.contributor.author | Penner-Hahn, James E. | |
dc.contributor.author | Sension, Roseanne J. | |
dc.date.accessioned | 2024-02-02T16:02:05Z | |
dc.date.available | 2024-02-02T16:02:05Z | |
dc.date.issued | 2023-11-23 | |
dc.identifier.citation | Journal of Physical Chemistry B, in press | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/191758 | en |
dc.description.abstract | Polarized time-resolved X-ray absorption spectroscopy at the Co K-edge is used to probe the excited state dynamics and photolysis of base-off methylcobalamin and the excited state structure of base-off adenosylcobalamin. For both molecules, the final excited state minimum shows evidence for an expansion of the cavity around the Co ion by ca. 0.04 Å to 0.05 Å. The 5-coordinate base-off cob(II)alamin that is formed following photodissociation is has a structure similar to that of 5-coordinate base-on cob(II)alamin, with a ring expansion of 0.03 Å to 0.04 Å and a contraction of the bond to the the lower axial ligand bond length relative to that in the 6-coordinate ground state. These data provide insights into the role of the lower axial ligand in modulating the reactivity of B12 coenzymes | en_US |
dc.description.sponsorship | National Science Foundation NSF-CHE 1836435 National Science Foundation NSF-CHE 2154157 NIH P41GM139687 U.S. Department of Energy, Office of Basic Energy Sciences Contract No. DE-AC02-76SF00515 | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | American Chemical Society | en_US |
dc.title | Ultrafast X-ray Absorption Spectroscopy Reveals Excited State Dynamics of B12 Coenzymes Controlled by the Axial Base | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Chemistry | |
dc.subject.hlbtoplevel | Science | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Chemistry, Department of | en_US |
dc.contributor.affiliationum | Biophysics, Department of | en_US |
dc.contributor.affiliationum | Physics, Department of | en_US |
dc.contributor.affiliationother | Linac Coherent Light Source, SLAC National Accelerator Laboratory | en_US |
dc.contributor.affiliationother | Stanford Synchrotron Radiation Light Source, SLAC National Accelerator Laboratory | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 38301132 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/191758/1/jpcb.3c07779 as accepted.pdf | |
dc.identifier.doi | 10.1021/acs.jpcb.3c07779 | |
dc.identifier.doi | https://dx.doi.org/10.7302/21937 | |
dc.identifier.source | Journal of Physical Chemistry B | en_US |
dc.identifier.orcid | 0000-0002-5357-0934 | en_US |
dc.identifier.orcid | 0000-0002-0331-9709 | en_US |
dc.identifier.orcid | 0000-0001-6458-3653 | en_US |
dc.identifier.orcid | 0000-0003-0314-1274 | en_US |
dc.identifier.orcid | 0000-0001-6758-0132 | en_US |
dc.identifier.orcid | 0000-0002-9629-890X | en_US |
dc.identifier.orcid | 0000-0002-4884-171X | en_US |
dc.identifier.orcid | 0000-0002-0154-9906 | en_US |
dc.identifier.orcid | 0000-0001-7155-2011 | en_US |
dc.identifier.orcid | 0000-0003-4070-3168 | en_US |
dc.description.depositor | SELF | en_US |
dc.identifier.name-orcid | alonso mori, roberto; 0000-0002-5357-0934 | en_US |
dc.identifier.name-orcid | Deb, Aniruddha; 0000-0002-0331-9709 | en_US |
dc.identifier.name-orcid | Lamb, Ryan; 0000-0001-6458-3653 | en_US |
dc.identifier.name-orcid | Penner-Hahn, James; 0000-0003-0314-1274 | en_US |
dc.identifier.name-orcid | Sension, Roseanne J; 0000-0001-6758-0132 | en_US |
dc.identifier.name-orcid | chollet, matthieu; 0000-0002-9629-890X | en_US |
dc.identifier.name-orcid | Garcia-Esparza, Angel T.; 0000-0002-4884-171X | en_US |
dc.identifier.name-orcid | Michocki, Lindsay; 0000-0002-0154-9906 | en_US |
dc.identifier.name-orcid | Reinhard, Marco; 0000-0001-7155-2011 | en_US |
dc.identifier.name-orcid | van Driel, Tim Brandt; 0000-0003-4070-3168 | en_US |
dc.working.doi | 10.7302/21937 | en_US |
dc.owningcollname | Chemistry, Department of |
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