Laryngotracheobronchial Amyloidosis: Patterns of Presentation and Management
dc.contributor.author | Dermody, SM | |
dc.contributor.author | Campagnaro, EL | |
dc.contributor.author | Kupfer, RA | |
dc.contributor.author | Hogikyan, ND | |
dc.contributor.author | Morrison, RJ | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-01-09T17:20:12Z | |
dc.date.available | 2024-01-09T17:20:12Z | |
dc.date.issued | 2022-07-01 | |
dc.identifier.issn | 0003-4894 | |
dc.identifier.issn | 1943-572X | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/34459282 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/191970 | en |
dc.description.abstract | Objective: To evaluate the pattern of presentation and management of laryngotracheobronchial amyloidosis at a tertiary care academic center over a 27 year period. Methods: In a retrospective review, the electronic medical record at a tertiary care academic center was queried for encounters with 3 laryngologists between 1996 and 2019 which included the ICD-9 or ICD-10 diagnosis of amyloidosis. Demographics, clinical presentation, referral diagnoses, medical history, family history, laboratory values, radiology studies, and treatment modalities of subjects were collated. Results were analyzed using standard univariate descriptive statistics. Results: Seventeen subjects were identified with an average age at diagnosis of 58 years (range 26-76 years). The most common amyloid type on biopsy was immunoglobulin light chain (AL) subtype. The most common location of laryngeal amyloid at diagnosis was the glottis and disease was more likely to be bilateral at the time of diagnosis in this location. Supraglottic disease more often had a unilateral presentation and had a tendency to spread to additional laryngeal subsites. Nearly 25% of subjects had associated systemic disease, including multiple myeloma, auto-immune disease, and familial ATTR mutation. Conclusions: The overall rate of associated systemic disease was low in our study cohort; however, it is higher than typically referenced in extant literature. Our cohort demonstrates that while laryngeal amyloidosis is a chronic condition, the behavior is generally indolent with a low treatment burden. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | SAGE Publications | |
dc.relation.haspart | ARTN 00034894211042772 | |
dc.subject | amyloidosis | |
dc.subject | laryngotracheobronchial | |
dc.subject | larynx | |
dc.subject | systemic disease | |
dc.subject | trachea | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Amyloid | |
dc.subject | Amyloidosis | |
dc.subject | Humans | |
dc.subject | Laryngeal Diseases | |
dc.subject | Larynx | |
dc.subject | Middle Aged | |
dc.subject | Retrospective Studies | |
dc.title | Laryngotracheobronchial Amyloidosis: Patterns of Presentation and Management | |
dc.type | Article | |
dc.identifier.pmid | 34459282 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/191970/2/2022_Annals of Otol Rhinol Laryngol_Laryngotracheobronchial Amyloidosis.pdf | |
dc.identifier.doi | 10.1177/00034894211042772 | |
dc.identifier.doi | https://dx.doi.org/10.7302/21971 | |
dc.identifier.source | Annals of Otology, Rhinology and Laryngology | |
dc.description.version | Published version | |
dc.date.updated | 2024-01-09T17:20:12Z | |
dc.identifier.orcid | 0000-0003-4928-967X | |
dc.identifier.orcid | 0009-0000-0757-8348 | |
dc.identifier.orcid | 0000-0003-1783-4338 | |
dc.identifier.orcid | 0000-0002-2313-8542 | |
dc.description.filedescription | Description of 2022_Annals of Otol Rhinol Laryngol_Laryngotracheobronchial Amyloidosis.pdf : Published version | |
dc.identifier.volume | 131 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 737 | |
dc.identifier.endpage | 742 | |
dc.identifier.name-orcid | Dermody, SM; 0000-0003-4928-967X | |
dc.identifier.name-orcid | Campagnaro, EL | |
dc.identifier.name-orcid | Kupfer, RA; 0009-0000-0757-8348 | |
dc.identifier.name-orcid | Hogikyan, ND; 0000-0003-1783-4338 | |
dc.identifier.name-orcid | Morrison, RJ; 0000-0002-2313-8542 | |
dc.working.doi | 10.7302/21971 | en |
dc.owningcollname | Otolaryngology, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.