Predictors of Early Lung Function in Patients with Congenital Diaphragmatic Hernia
dc.contributor.author | Wright, T | |
dc.contributor.author | Filbrun, A | |
dc.contributor.author | Bryner, B | |
dc.contributor.author | Mychaliska, GB | |
dc.coverage.spatial | Orlando, Florida | |
dc.date.accessioned | 2024-01-12T14:37:19Z | |
dc.date.available | 2024-01-12T14:37:19Z | |
dc.date.issued | 2014-01-01 | |
dc.identifier.issn | 0022-3468 | |
dc.identifier.issn | 1531-5037 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/24888827 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/192031 | en |
dc.description.abstract | Purpose Long-term pulmonary outcomes of congenital diaphragmatic hernia (CDH) have demonstrated airflow obstruction in later childhood. We examined pulmonary function data to assess what factors predict lung function in the first three years of life in children with CDH. Methods This was a retrospective study of patients treated for CDH who underwent infant pulmonary function testing (IPFT) between 2006 and 2012. IPFT was performed using the raised volume rapid thoracoabdominal compression technique and plethysmography. Results Twenty-nine neonates with CDH had IPFTs in the first 3 years of life. Their mean predicted survival using the CDH Study Group equation was 63% ± 4%. Fourteen infants (48%) required extracorporeal membrane oxygenation (ECMO). The mean age at IPFT was 85.1 ± 5 weeks. Airflow obstruction was the most common abnormality, seen in 14 subjects. 12 subjects had air trapping, and 9 demonstrated restrictive disease. ECMO (p = 0.002), days on the ventilator (p = 0.028), and days on oxygen (p = 0.023) were associated with restrictive lung disease. Conclusion Despite following a group of patients with severe CDH, lung function revealed mild deficits in the first three years of life. Clinical markers of increased severity (ECMO, ventilator days, and prolonged oxygen use) are correlated with reduced lung function. © 2014 Elsevier Inc. | |
dc.format.medium | Print-Electronic | |
dc.publisher | Elsevier | |
dc.subject | Air flow obstruction | |
dc.subject | Air trapping | |
dc.subject | Congenital diaphragmatic hernia | |
dc.subject | Pulmonary function | |
dc.subject | Restrictive lung disease | |
dc.subject | Child, Preschool | |
dc.subject | Early Diagnosis | |
dc.subject | Female | |
dc.subject | Follow-Up Studies | |
dc.subject | Forced Expiratory Flow Rates | |
dc.subject | Hernias, Diaphragmatic, Congenital | |
dc.subject | Humans | |
dc.subject | Infant | |
dc.subject | Infant, Newborn | |
dc.subject | Lung | |
dc.subject | Male | |
dc.subject | Plethysmography | |
dc.subject | Predictive Value of Tests | |
dc.subject | Respiratory Function Tests | |
dc.subject | Retrospective Studies | |
dc.subject | Time Factors | |
dc.subject | Vital Capacity | |
dc.title | Predictors of Early Lung Function in Patients with Congenital Diaphragmatic Hernia | |
dc.type | Conference Paper | |
dc.identifier.pmid | 24888827 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/192031/2/Predictors of early lung function in patients with congenital diaphragmatic hernia.pdf | |
dc.identifier.doi | 10.1016/j.jpedsurg.2014.01.016 | |
dc.identifier.doi | https://dx.doi.org/10.7302/22032 | |
dc.identifier.source | Journal of Pediatric Surgery | |
dc.description.version | Published version | |
dc.date.updated | 2024-01-12T14:37:19Z | |
dc.description.filedescription | Description of Predictors of early lung function in patients with congenital diaphragmatic hernia.pdf : Published version | |
dc.identifier.volume | 49 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 882 | |
dc.identifier.endpage | 885 | |
dc.identifier.name-orcid | Wright, T | |
dc.identifier.name-orcid | Filbrun, A | |
dc.identifier.name-orcid | Bryner, B | |
dc.identifier.name-orcid | Mychaliska, GB | |
dc.working.doi | 10.7302/22032 | en |
dc.owningcollname | Pediatrics and Communicable Diseases, Department of |
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