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Selectively Targeting Tropomyosin Receptor Kinase A (TRKA) via PROTACs
dc.contributor.authorXiang, W
dc.contributor.authorWang, S
dc.coverage.spatialUnited States
dc.date.accessioned2024-01-23T21:16:51Z
dc.date.available2024-01-23T21:16:51Z
dc.date.issued2020-12-10
dc.identifier.issn0022-2623
dc.identifier.issn1520-4804
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/33206509
dc.identifier.urihttps://hdl.handle.net/2027.42/192131en
dc.description.abstractTropomyosin receptor kinases (TRKs) are promising cancer therapeutic targets. Chen et al. (J. Med. Chem. 2020, DOI: 10.1021/acs.jmedchem.0c01342) report the discovery of CG416 and CG428 as two potent small-molecule proteolysis-targeting chimera (PROTAC) degraders selective for TRKA over TRKB and TRKC. CG416 and CG428 are valuable research tool compounds for in vitro and in vivo studies and promising lead compounds for further optimization.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherAmerican Chemical Society (ACS)
dc.subjectAnimals
dc.subjectCell Line
dc.subjectCell Proliferation
dc.subjectHumans
dc.subjectMice
dc.subjectProtein Kinase Inhibitors
dc.subjectProteolysis
dc.subjectProteomics
dc.subjectReceptor, trkA
dc.titleSelectively Targeting Tropomyosin Receptor Kinase A (TRKA) via PROTACs
dc.typeArticle
dc.identifier.pmid33206509
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/192131/2/xiang-wang-2020-selectively-targeting-tropomyosin-receptor-kinase-a-(trka)-via-protacs.pdf
dc.identifier.doi10.1021/acs.jmedchem.0c01947
dc.identifier.doihttps://dx.doi.org/10.7302/22131
dc.identifier.sourceJournal of Medicinal Chemistry
dc.description.versionPublished version
dc.date.updated2024-01-23T21:16:50Z
dc.identifier.orcid0000-0002-8782-6950
dc.identifier.volume63
dc.identifier.issue23
dc.identifier.startpage14560
dc.identifier.endpage14561
dc.identifier.name-orcidXiang, W
dc.identifier.name-orcidWang, S; 0000-0002-8782-6950
dc.working.doi10.7302/22131en
dc.owningcollnameInternal Medicine, Department of


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