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MCL-1 inhibition in cancer treatment
dc.contributor.authorXiang, W
dc.contributor.authorYang, CY
dc.contributor.authorBai, L
dc.coverage.spatialNew Zealand
dc.date.accessioned2024-01-23T21:20:56Z
dc.date.available2024-01-23T21:20:56Z
dc.date.issued2018-01-01
dc.identifier.issn1178-6930
dc.identifier.issn1178-6930
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/30425521
dc.identifier.urihttps://hdl.handle.net/2027.42/192137en
dc.description.abstractMyeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins, is a key regulator of mitochondrial homeostasis. Frequent overexpression of MCL-1 in human primary and drug-resistant cancer cells makes it an attractive cancer therapeutic target. Significant progress has been made in the development of small-molecule MCL-1 inhibitors in recent years, and three MCL-1 selective inhibitors have advanced to clinical trials. This review briefly discusses recent advances in the development of small molecules targeting MCL-1 for cancer therapy.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherTaylor & Francis
dc.rightsLicence for published version: Creative Commons Attribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectBAK
dc.subjectBAX
dc.subjectBCL-2
dc.subjectBH3 mimetics
dc.subjectapoptosis
dc.titleMCL-1 inhibition in cancer treatment
dc.typeArticle
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/192137/2/MCL-1 inhibition in cancer treatment.pdf
dc.identifier.doi10.2147/OTT.S146228
dc.identifier.doihttps://dx.doi.org/10.7302/22137
dc.identifier.sourceOncoTargets and Therapy
dc.description.versionPublished version
dc.date.updated2024-01-23T21:20:52Z
dc.identifier.orcid0000-0002-5445-0109
dc.identifier.orcid0000-0003-1025-2925
dc.identifier.volume11
dc.identifier.startpage7301
dc.identifier.endpage7314
dc.identifier.name-orcidXiang, W
dc.identifier.name-orcidYang, CY; 0000-0002-5445-0109
dc.identifier.name-orcidBai, L; 0000-0003-1025-2925
dc.working.doi10.7302/22137en
dc.owningcollnameInternal Medicine, Department of


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Licence for published version: Creative Commons Attribution-NonCommercial 4.0 International
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