Protocol for a Systematic Review and Meta-Analysis: Hemodialysis vs. Peritoneal Dialysis in COVID-19 AKI

Abstract

Background:Acute Kidney Injury (AKI) is pervasive in COVID-19 patients, affecting up to 50% of hospitalized individuals and posing graver risks for the critically ill. Renal Replacement Therapy (RRT), often necessary, involves Hemodialysis (HD) or Peritoneal Dialysis (PD). The optimal choice between HD and PD, particularly their impact on mortality, remains uncertain, creating a crucial knowledge gap. This systematic review and meta-analysis aim to address this gap by thoroughly examining existing evidence and comparing clinical outcomes, specifically mortality, in COVID-19 patients necessitating RRT.

Objectives: aims to: Compare clinical outcomes between hemodialysis and peritoneal dialysis in COVID-19 AKI patients.

Methods: Following the Cochrane Handbook for Systematic Reviews of Interventions, we will search electronic databases, screen studies using Rayyan software with independent reviewers, and extract data with standardized forms. To ensure rigor, Revman software will be used for pooled effect size calculations and heterogeneity assessment.

Significance: By transparently comparing modalities and exploring mortality determinants, SAMcov19-HDvPD will provide valuable insights to inform clinical decision-making and improve care for COVID-19 AKI patients requiring dialysis.