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Association between military service and Alzheimer’s disease neuropathology at autopsy
dc.contributor.authorPowell, W. Ryan
dc.contributor.authorVilen, Leigha
dc.contributor.authorZuelsdorff, Megan
dc.contributor.authorGoutman, Stephen A.
dc.contributor.authorSalamat, Shahriar
dc.contributor.authorRissman, Robert A.
dc.contributor.authorBendlin, Barbara B.
dc.contributor.authorKind, Amy J. H.
dc.date.accessioned2024-03-04T15:43:22Z
dc.date.available2025-03-04 10:43:21en
dc.date.available2024-03-04T15:43:22Z
dc.date.issued2024-02
dc.identifier.citationPowell, W. Ryan; Vilen, Leigha; Zuelsdorff, Megan; Goutman, Stephen A.; Salamat, Shahriar; Rissman, Robert A.; Bendlin, Barbara B.; Kind, Amy J. H. (2024). "Association between military service and Alzheimer’s disease neuropathology at autopsy." Alzheimer’s & Dementia 20(2): 1468-1474.
dc.identifier.issn1552-5260
dc.identifier.issn1552-5279
dc.identifier.urihttps://hdl.handle.net/2027.42/192586
dc.description.abstractINTRODUCTIONAnti-amyloid therapies are at the forefront of efforts to treat Alzheimer’s disease (AD). Identifying amyloid risk factors may aid screening and intervention strategies. While veterans face increased exposure to risk factors, whether they face a greater neuropathologic amyloid burden is not well understood.METHODSMale decedents donating to two Alzheimer’s Disease Research Center (ADRC) brain banks from 1986 to 2018 with categorized neuritic plaque density and neurofibrillary tangles (n = 597) were included. Using generalized ordered logistic regression we modeled each outcome’s association with military history adjusting for age and death year.RESULTSHaving served in the military (60% of sample) is associated with post mortem neuritic amyloid plaque (for each comparison of higher to lower C scores OR = 1.26; 95% confidence interval [CI] = 1.06–1.49) and tau pathology (B score OR = 1.10; 95% CI = 1.08–1.12).DISCUSSIONThis is the first study, to our knowledge, finding increased levels of verified AD neuropathology in those with military service. Targeted veteran AD therapies is a pressing need.
dc.publisherWiley Periodicals, Inc.
dc.publisherAncestry Publishing
dc.subject.otherAlzheimer’s disease risk
dc.subject.otheramyloid positivity
dc.subject.othermilitary exposome
dc.subject.othermilitary risk factors
dc.subject.otherneurofibrillary pathology
dc.subject.otherneuropathology
dc.subject.othersocial determinants of health
dc.subject.othersocial exposome
dc.titleAssociation between military service and Alzheimer’s disease neuropathology at autopsy
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurology and Neurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/192586/1/alz13520-sup-0001-SuppMat.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/192586/2/alz13520.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/192586/3/alz13520_am.pdf
dc.identifier.doi10.1002/alz.13520
dc.identifier.sourceAlzheimer’s & Dementia
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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