How Broad Should Gram-Negative Coverage Be for Febrile Parenteral Nutrition Dependent Short Bowel Syndrome Patients?
dc.contributor.author | Stultz, JS | |
dc.contributor.author | Fly, JH | |
dc.contributor.author | Bagga, B | |
dc.contributor.author | Arnold, SR | |
dc.contributor.author | Algotar, A | |
dc.contributor.author | Lee, KR | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-03-14T16:06:45Z | |
dc.date.available | 2024-03-14T16:06:45Z | |
dc.date.issued | 2022-06-01 | |
dc.identifier.issn | 0277-2116 | |
dc.identifier.issn | 1536-4801 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/35045560 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/192638 | en |
dc.description.abstract | ABSTRACT: Broader spectrum Gram-negative antibiotics are commonly utilized empirically for central line-associated bloodstream infections (CLABSI) in febrile short bowel syndrome (SBS) patients receiving home parenteral nutrition compared to those used empirically for inpatient-acquired CLABSI. This analysis reports 57 CLABSI in 22 patients with SBS admitted from the community and 78 inpatient-acquired CLABSI in 76 patients over a 5-year period. Proportional Gram-negative CLABSI was similar between the SBS and inpatient-acquired cohorts (43.8% vs42.3%, respectively, P = 0.78). 1.8% and 10.3% (P = 0.125) of Gram-negative CLABSI were non-susceptible to ceftriaxone and 0% and 3.8% (P = 0.52) were non-susceptible to ceftazidime in the SBS and inpatient-acquired cohorts, respectively. In the SBS cohort, home ethanol lock therapy and prior culture results impacted Gramnegative pathogen distribution. Broader empiric Gram-negative coverage for CLABSI among SBS patients compared to inpatients is unnecessary. Third-generation cephalosporins represent appropriate empiric Gramnegative agents for febrile SBS patients presenting from the community to our institution. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | Wiley | |
dc.subject | Anti-Bacterial Agents | |
dc.subject | Catheter-Related Infections | |
dc.subject | Catheterization, Central Venous | |
dc.subject | Fever | |
dc.subject | Humans | |
dc.subject | Parenteral Nutrition, Home | |
dc.subject | Parenteral Nutrition, Total | |
dc.subject | Short Bowel Syndrome | |
dc.title | How Broad Should Gram-Negative Coverage Be for Febrile Parenteral Nutrition Dependent Short Bowel Syndrome Patients? | |
dc.type | Article | |
dc.identifier.pmid | 35045560 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/192638/2/How Broad Should Gram-Negative Coverage Be for Febrile Parenteral Nutrition Dependent Short Bowel Syndrome Patients.pdf | |
dc.identifier.doi | 10.1097/MPG.0000000000003382 | |
dc.identifier.doi | https://dx.doi.org/10.7302/22454 | |
dc.identifier.source | Journal of pediatric gastroenterology and nutrition | |
dc.description.version | Published version | |
dc.date.updated | 2024-03-14T16:06:43Z | |
dc.identifier.orcid | 0000-0002-9566-9377 | |
dc.identifier.volume | 74 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 845 | |
dc.identifier.endpage | 849 | |
dc.identifier.name-orcid | Stultz, JS | |
dc.identifier.name-orcid | Fly, JH | |
dc.identifier.name-orcid | Bagga, B | |
dc.identifier.name-orcid | Arnold, SR | |
dc.identifier.name-orcid | Algotar, A; 0000-0002-9566-9377 | |
dc.identifier.name-orcid | Lee, KR | |
dc.working.doi | 10.7302/22454 | en |
dc.owningcollname | Pediatrics and Communicable Diseases, Department of |
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