Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging
dc.contributor.author | Ghosh, AK | |
dc.contributor.author | O'Brien, M | |
dc.contributor.author | Mau, T | |
dc.contributor.author | Yung, R | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-05-06T19:08:05Z | |
dc.date.available | 2024-05-06T19:08:05Z | |
dc.date.issued | 2017-09-01 | |
dc.identifier.issn | 1945-4589 | |
dc.identifier.issn | 1945-4589 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/28898202 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/193086 | en |
dc.description.abstract | Adipose tissue (AT) inflammation is a central mechanism for metabolic dysfunction in both diet-induced obesity and age-associated obesity. Studies in diet-induced obesity have characterized the role of Fetuin A (Fet A) in Free Fatty Acids (FFA)-mediated TLR4 activation and adipose tissue inflammation. However, the role of Fet A & TLR4 in aging-related adipose tissue inflammation is unknown. In the current study, analysis of epidymymal fat pads of C57/Bl6 male mice, we found that, in contrast to data from diet-induced obesity models, adipose tissue from aged mice have normal Fet A and TLR4 expression. Interestingly, aged TLR4-deficient mice have diminished adipose tissue inflammation compared to normal controls. We further demonstrated that reduced AT inflammation in old TLR4-deficient mice is linked to impaired ER stress, augmented autophagy activity, and diminished senescence phenomenon. Importantly, old TLR4-deficient mice have improved glucose tolerance compared to age-matched wild type mice, suggesting that the observed reduced AT inflammation in aged TLR4- deficient mice has important physiological consequences. Taken together, our present study establishes novel aspect of aging-associated AT inflammation that is distinct from diet-induced AT inflammation. Our results also provide strong evidence that TLR4 plays a significant role in promoting aging adipose tissue inflammation. | |
dc.format.medium | ||
dc.language | eng | |
dc.publisher | Impact Journals | |
dc.rights | Licence for published version: Creative Commons Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Inflammation | |
dc.subject | aging | |
dc.subject | obesity | |
dc.subject | Adipose Tissue | |
dc.subject | Aging | |
dc.subject | Animals | |
dc.subject | Inflammation | |
dc.subject | Male | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice, Knockout | |
dc.subject | Toll-Like Receptor 4 | |
dc.title | Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging | |
dc.type | Article | |
dc.identifier.pmid | 28898202 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/193086/2/aging-09-1971.pdf | |
dc.identifier.doi | 10.18632/aging.101288 | |
dc.identifier.doi | https://dx.doi.org/10.7302/22731 | |
dc.identifier.source | Aging | |
dc.description.version | Published version | |
dc.date.updated | 2024-05-06T19:08:04Z | |
dc.identifier.orcid | 0000-0002-8181-027X | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 9 | |
dc.identifier.startpage | 1971 | |
dc.identifier.endpage | 1982 | |
dc.identifier.name-orcid | Ghosh, AK | |
dc.identifier.name-orcid | O'Brien, M | |
dc.identifier.name-orcid | Mau, T | |
dc.identifier.name-orcid | Yung, R; 0000-0002-8181-027X | |
dc.working.doi | 10.7302/22731 | en |
dc.owningcollname | Internal Medicine, Department of |
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