Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms
dc.contributor.author | Figueroa-Romero, C | |
dc.contributor.author | Hur, J | |
dc.contributor.author | Lunn, JS | |
dc.contributor.author | Paez-Colasante, X | |
dc.contributor.author | Bender, DE | |
dc.contributor.author | Yung, R | |
dc.contributor.author | Sakowski, SA | |
dc.contributor.author | Feldman, EL | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-05-06T19:17:06Z | |
dc.date.available | 2024-05-06T19:17:06Z | |
dc.date.issued | 2016-03-01 | |
dc.identifier.issn | 1044-7431 | |
dc.identifier.issn | 1095-9327 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/26704906 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/193091 | en |
dc.description.abstract | Amyotrophic lateral sclerosis is a late-onset and terminal neurodegenerative disease. The majority of cases are sporadic with unknown causes and only a small number of cases are genetically linked. Recent evidence suggests that post-transcriptional regulation and epigenetic mechanisms, such as microRNAs, underlie the onset and progression of neurodegenerative disorders; therefore, altered microRNA expression may result in the dysregulation of key genes and biological pathways that contribute to the development of sporadic amyotrophic lateral sclerosis. Using systems biology analyses on postmortem human spinal cord tissue, we identified dysregulated mature microRNAs and their potential targets previously implicated in functional process and pathways associated with the pathogenesis of ALS. Furthermore, we report a global reduction of mature microRNAs, alterations in microRNA processing, and support for a role of the nucleotide binding protein, TAR DNA binding protein 43, in regulating sporadic amyotrophic lateral sclerosis-associated microRNAs, thereby offering a potential underlying mechanism for sporadic amyotrophic lateral sclerosis. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.subject | Amyotrophic lateral sclerosis | |
dc.subject | Epigenetics | |
dc.subject | MicroRNA | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Amyotrophic Lateral Sclerosis | |
dc.subject | Case-Control Studies | |
dc.subject | DNA-Binding Proteins | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | MicroRNAs | |
dc.subject | Middle Aged | |
dc.subject | Spinal Cord | |
dc.title | Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms | |
dc.type | Article | |
dc.identifier.pmid | 26704906 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/193091/2/nihms-748924.pdf | |
dc.identifier.doi | 10.1016/j.mcn.2015.12.008 | |
dc.identifier.doi | https://dx.doi.org/10.7302/22736 | |
dc.identifier.source | Molecular and Cellular Neuroscience | |
dc.description.version | Published version | |
dc.date.updated | 2024-05-06T19:17:05Z | |
dc.identifier.orcid | 0000-0001-7546-4190 | |
dc.identifier.orcid | 0000-0002-0736-2149 | |
dc.identifier.orcid | 0000-0002-8181-027X | |
dc.identifier.orcid | 0000-0002-5064-9022 | |
dc.identifier.orcid | 0000-0002-9162-2694 | |
dc.identifier.volume | 71 | |
dc.identifier.startpage | 34 | |
dc.identifier.endpage | 45 | |
dc.identifier.name-orcid | Figueroa-Romero, C; 0000-0001-7546-4190 | |
dc.identifier.name-orcid | Hur, J; 0000-0002-0736-2149 | |
dc.identifier.name-orcid | Lunn, JS | |
dc.identifier.name-orcid | Paez-Colasante, X | |
dc.identifier.name-orcid | Bender, DE | |
dc.identifier.name-orcid | Yung, R; 0000-0002-8181-027X | |
dc.identifier.name-orcid | Sakowski, SA; 0000-0002-5064-9022 | |
dc.identifier.name-orcid | Feldman, EL; 0000-0002-9162-2694 | |
dc.working.doi | 10.7302/22736 | en |
dc.owningcollname | Neurology, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.