Changes in adipose tissue macrophages and T cells in aging.
dc.contributor.author | Garg, SK | |
dc.contributor.author | Delaney, C | |
dc.contributor.author | Shi, H | |
dc.contributor.author | Yung, R | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-05-06T19:28:17Z | |
dc.date.available | 2024-05-06T19:28:17Z | |
dc.date.issued | 2014-01-01 | |
dc.identifier.issn | 1040-8401 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/24579699 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/193097 | en |
dc.description.abstract | Adipose tissue historically was believed to be an inert tissue, functioning primarily in the storage of energy and thermal homeostasis. However, recent discoveries point toward a critical role for adipocytes in endocrine function as well as immune regulation. Excess body fat, accumulated through aging and/or a calorie-rich diet, is associated with many chronic metabolic and inflammatory diseases. Within the stromal vascular fraction of adipose tissue, macrophages and T cells accumulate with increasing tissue mass, secreting pro- or anti-inflammatory cytokines. In this review we discuss the current understanding of immune cell function in both diet-induced and age-related obesity. In both models of obesity, the classically activated, pro-inflammatory (M1) subtype takes precedence over the alternatively activated, anti-inflammatory (M2) macrophages, causing tissue necrosis and releasing pro-inflammatory cytokines like interleukin-6. Other distinct adipose tissue macrophage subtypes have been identified by surface marker expression and their functions characterized. Adipose tissue T cell recruitment to adipose tissue is also different between aging- and diet-induced obesity. Under both conditions, T cells exhibit restricted T-cell receptor diversity and produce higher levels of pro-inflammatory signals like interferon-γ and granzyme B relative to young or healthy mice. However, numbers of regulatory T cells are dramatically different between the 2 models of obesity. Taken together, these findings suggest models of age- and diet-induced obesity may be more distinct than previously thought, with many questions yet to be resolved in this multidimensional disease. © 2014 Begell House, Inc. | |
dc.format.medium | ||
dc.language | eng | |
dc.publisher | Begell House | |
dc.subject | Adipose Tissue | |
dc.subject | Aging | |
dc.subject | Animals | |
dc.subject | Cytokines | |
dc.subject | Humans | |
dc.subject | Inflammation Mediators | |
dc.subject | Macrophages | |
dc.subject | Mice | |
dc.subject | Obesity | |
dc.subject | T-Lymphocytes | |
dc.title | Changes in adipose tissue macrophages and T cells in aging. | |
dc.type | Article | |
dc.identifier.pmid | 24579699 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/193097/2/nihms516202.pdf | |
dc.identifier.doi | 10.1615/CritRevImmunol.2013006833 | |
dc.identifier.doi | https://dx.doi.org/10.7302/22742 | |
dc.identifier.source | Critical Reviews in Immunology | |
dc.description.version | Published version | |
dc.date.updated | 2024-05-06T19:28:15Z | |
dc.identifier.orcid | 0000-0002-8181-027X | |
dc.identifier.volume | 34 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 14 | |
dc.identifier.name-orcid | Garg, SK | |
dc.identifier.name-orcid | Delaney, C | |
dc.identifier.name-orcid | Shi, H | |
dc.identifier.name-orcid | Yung, R; 0000-0002-8181-027X | |
dc.working.doi | 10.7302/22742 | en |
dc.owningcollname | Internal Medicine, Department of |
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