Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration
dc.contributor.author | Passino, R | |
dc.contributor.author | Finneran, MC | |
dc.contributor.author | Hafner, H | |
dc.contributor.author | Feng, Q | |
dc.contributor.author | Huffman, LD | |
dc.contributor.author | Zhao, XF | |
dc.contributor.author | Johnson, CN | |
dc.contributor.author | Kawaguchi, R | |
dc.contributor.author | Oses-Prieto, JA | |
dc.contributor.author | Burlingame, AL | |
dc.contributor.author | Geschwind, DH | |
dc.contributor.author | Benowitz, LI | |
dc.contributor.author | Giger, RJ | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-05-21T15:13:13Z | |
dc.date.available | 2024-05-21T15:13:13Z | |
dc.date.issued | 2024-03-26 | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/38492223 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/193166 | en |
dc.description.abstract | In adult mammals, injured retinal ganglion cells (RGCs) fail to spontaneously regrow severed axons, resulting in permanent visual deficits. Robust axon growth, however, is observed after intra-ocular injection of particulate β-glucan isolated from yeast. Blood-borne myeloid cells rapidly respond to β-glucan, releasing numerous pro-regenerative factors. Unfortunately, the pro-regenerative effects are undermined by retinal damage inflicted by an overactive immune system. Here, we demonstrate that protection of the inflamed vasculature promotes immune-mediated RGC regeneration. In the absence of microglia, leakiness of the blood-retina barrier increases, pro-inflammatory neutrophils are elevated, and RGC regeneration is reduced. Functional ablation of the complement receptor 3 (CD11b/integrin-αM), but not the complement components C1q−/− or C3−/−, reduces ocular inflammation, protects the blood-retina barrier, and enhances RGC regeneration. Selective targeting of neutrophils with anti-Ly6G does not increase axogenic neutrophils but protects the blood-retina barrier and enhances RGC regeneration. Together, these findings reveal that protection of the inflamed vasculature promotes neuronal regeneration. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation.haspart | 113931 | |
dc.rights | Licence for published version: Creative Commons Attribution-NonCommercial 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject | CD11 | |
dc.subject | CP: Neuroscience | |
dc.subject | axon regeneration | |
dc.subject | blood-retina barrier | |
dc.subject | microglia | |
dc.subject | neutrophils | |
dc.subject | retinal gangl retinal ganglion cells | |
dc.subject | vascular inflammation | |
dc.subject | Animals | |
dc.subject | Neutrophils | |
dc.subject | Optic Nerve Injuries | |
dc.subject | Nerve Regeneration | |
dc.subject | Retinal Ganglion Cells | |
dc.subject | Axons | |
dc.subject | beta-Glucans | |
dc.subject | Mammals | |
dc.title | Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration | |
dc.type | Article | |
dc.identifier.pmid | 38492223 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/193166/2/XF_25_neutrophil-inflicted vasculature damage suppresses immune-mediated ON rege_2024.pdf | |
dc.identifier.doi | 10.1016/j.celrep.2024.113931 | |
dc.identifier.doi | https://dx.doi.org/10.7302/22811 | |
dc.identifier.source | Cell Reports | |
dc.description.version | Published version | |
dc.date.updated | 2024-05-21T15:13:08Z | |
dc.identifier.orcid | 0000-0002-7574-7163 | |
dc.identifier.orcid | 0000-0002-2926-3336 | |
dc.description.filedescription | Description of XF_25_neutrophil-inflicted vasculature damage suppresses immune-mediated ON rege_2024.pdf : Published version | |
dc.identifier.volume | 43 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 113931 | |
dc.identifier.name-orcid | Passino, R | |
dc.identifier.name-orcid | Finneran, MC | |
dc.identifier.name-orcid | Hafner, H | |
dc.identifier.name-orcid | Feng, Q | |
dc.identifier.name-orcid | Huffman, LD | |
dc.identifier.name-orcid | Zhao, XF; 0000-0002-7574-7163 | |
dc.identifier.name-orcid | Johnson, CN | |
dc.identifier.name-orcid | Kawaguchi, R | |
dc.identifier.name-orcid | Oses-Prieto, JA | |
dc.identifier.name-orcid | Burlingame, AL | |
dc.identifier.name-orcid | Geschwind, DH | |
dc.identifier.name-orcid | Benowitz, LI | |
dc.identifier.name-orcid | Giger, RJ; 0000-0002-2926-3336 | |
dc.working.doi | 10.7302/22811 | en |
dc.owningcollname | Michigan Research Experts Deposits |
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