"Hyper-homocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model".
dc.contributor.author | Hofmann, MA | |
dc.contributor.author | Lalla, E | |
dc.contributor.author | Lu, Y | |
dc.contributor.author | Gleason, MR | |
dc.contributor.author | Wolf, BM | |
dc.contributor.author | Tanji, N | |
dc.contributor.author | Ferran, LJ | |
dc.contributor.author | Kohl, B | |
dc.contributor.author | Rao, V | |
dc.contributor.author | Kisiel, W | |
dc.contributor.author | Stern, DM | |
dc.contributor.author | Schmidt, AM | |
dc.coverage.spatial | Sorronto, Italy | |
dc.date.accessioned | 2024-05-21T19:42:33Z | |
dc.date.available | 2024-05-21T19:42:33Z | |
dc.date.issued | 2001-04-01 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/11254667 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/193172 | en |
dc.description.abstract | Although hyperhomocysteinemia (HHcy) is a well-known risk factor for the development of cardiovascular disease, the underlying molecular mechanisms are not fully elucidated. Here we show that induction of HHcy in apoE-null mice by a diet enriched in methionine but depleted in folate and vitamins B6 and B12 increased atherosclerotic lesion area and complexity, and enhanced expression of receptor for advanced glycation end products (RAGE), VCAM-1, tissue factor, and MMP-9 in the vasculature. These homocysteine-mediated (HC-mediated) effects were significantly suppressed, in parallel with decreased levels of plasma HC, upon dietary supplementation with folate and vitamins B6/B12. These findings implicate HHcy in atherosclerotic plaque progression and stability, and they suggest that dietary enrichment in vitamins essential for the metabolism of HC may impart protective effects in the vasculature. | |
dc.description.sponsorship | International Conference on Homocysteine Metabolism | |
dc.language | eng | |
dc.subject | Animals | |
dc.subject | Apolipoproteins E | |
dc.subject | Arteriosclerosis | |
dc.subject | Cells, Cultured | |
dc.subject | Diet | |
dc.subject | Disease Models, Animal | |
dc.subject | Folic Acid | |
dc.subject | Humans | |
dc.subject | Hyperhomocysteinemia | |
dc.subject | Immunohistochemistry | |
dc.subject | Male | |
dc.subject | Matrix Metalloproteinase 9 | |
dc.subject | Methionine | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice, Knockout | |
dc.subject | Pyridoxine | |
dc.subject | Receptor for Advanced Glycation End Products | |
dc.subject | Receptors, Immunologic | |
dc.subject | Thromboplastin | |
dc.subject | Vascular Cell Adhesion Molecule-1 | |
dc.subject | Vasculitis | |
dc.subject | Vitamin B 12 | |
dc.title | "Hyper-homocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model". | |
dc.type | Presentation | |
dc.identifier.pmid | 11254667 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/193172/2/Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model.pdf | |
dc.identifier.doi | 10.1172/JCI10588 | |
dc.identifier.doi | https://dx.doi.org/10.7302/22817 | |
dc.date.updated | 2024-05-21T19:42:32Z | |
dc.description.filedescription | Description of Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model.pdf : Published version | |
dc.identifier.name-orcid | Hofmann, MA | |
dc.identifier.name-orcid | Lalla, E | |
dc.identifier.name-orcid | Lu, Y | |
dc.identifier.name-orcid | Gleason, MR | |
dc.identifier.name-orcid | Wolf, BM | |
dc.identifier.name-orcid | Tanji, N | |
dc.identifier.name-orcid | Ferran, LJ | |
dc.identifier.name-orcid | Kohl, B | |
dc.identifier.name-orcid | Rao, V | |
dc.identifier.name-orcid | Kisiel, W | |
dc.identifier.name-orcid | Stern, DM | |
dc.identifier.name-orcid | Schmidt, AM | |
dc.working.doi | 10.7302/22817 | en |
dc.owningcollname | Internal Medicine, Department of |
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