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Biomarkers associated with toxicities related to CD19 chimeric antigen receptor T-cell (CAR-T) therapy in patients with relapsed/refractory B-cell leukemia and lymphoma: a scoping review protocol
dc.contributor.authorAgrusa, Jennifer E.
dc.date.accessioned2024-11-15T17:31:41Z
dc.date.available2024-11-15T17:31:41Z
dc.date.issued2024-11-15
dc.identifier.urihttps://hdl.handle.net/2027.42/195598en
dc.descriptionAnti-CD19 chimeric antigen receptor-modified T-cell (CAR-T) therapy is a type of targeted therapy that has improved outcomes for children and adults with relapsed/refractory CD19+ B-cell leukemia or lymphoma. This therapy, however, is associated with toxicities, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), which can lead to morbidity and mortality for affected patients. Clinical and biological risk factors are being studied in an effort to mitigate the risk of these toxicities and improve overall outcomes relating to CAR-T therapy. The objective of this scoping review is to ascertain the repertoire of biomarkers that have been associated with toxicities related to CAR-T therapy in children and adults with relapsed/refractory B-cell leukemias and lymphomas.en_US
dc.language.isoen_USen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCAR-Ten_US
dc.subjectbiomarkeren_US
dc.subjectleukemiaen_US
dc.subjectlymphomaen_US
dc.subjectscoping reviewen_US
dc.titleBiomarkers associated with toxicities related to CD19 chimeric antigen receptor T-cell (CAR-T) therapy in patients with relapsed/refractory B-cell leukemia and lymphoma: a scoping review protocolen_US
dc.typeWorking Paperen_US
dc.subject.hlbsecondlevelPediatrics
dc.subject.hlbtoplevelHealth Sciences
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/195598/1/CART Biomarker Scoping Review Protocol.docx
dc.identifier.doihttps://dx.doi.org/10.7302/24670
dc.identifier.orcid0000-0002-8932-863xen_US
dc.description.depositorSELFen_US
dc.owningcollnamePediatrics and Communicable Diseases, Department of


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International

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