Now showing items 2291-2297 of 2297
High-Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single-Cell Level
(Wiley Periodicals, Inc., 2023-02)
Cancer cell migration represents an essential step toward metastasis and cancer deaths. However, conventional drug discovery focuses on cytotoxic and growth-inhibiting compounds rather than inhibitors of migration. Drug ...
Reply to Correspondence on “Synergy and Antagonism between Allosteric and Active-Site Inhibitors of Abl Tyrosine Kinase”
(Wiley Periodicals, Inc., 2022-11-14)
Manley and co-workers provide data demonstrating that, at super-pharmacological concentrations (300 μM), a ternary complex between Abl, asciminib, and ATP-competitive inhibitors is possible. The work in our manuscript ...
Unique Dimerization Topology and Countercation Binding Modes in 12-Metallacrown-4 Compounds
(Wiley-VCH Verlap & Co. KGaA, 2022-11-17)
Seven dimeric metallacrowns (MC) based on Ln[12-MCM(III)N(shi)-4], where LnIII=Dy, Ho, Yb, or Y, MIII=Mn or Ga, and shi3− is salicylhydroximate, have been synthesized and characterized by single-crystal X-ray diffraction, ...
Engineering Functional Membrane–Membrane Interfaces by InterSpy
(Wiley Periodicals, Inc., 2023-03)
Engineering synthetic interfaces between membranes has potential applications in designing non-native cellular communication pathways and creating synthetic tissues. Here, InterSpy is introduced as a synthetic biology tool ...
High-Energy Aqueous Magnesium Ion Batteries with Capacity-Compensation Evolved from Dynamic Copper Ion Redox
(Wiley Periodicals, Inc., 2023-05)
The low specific capacity and low voltage plateau are significant challenges in the advancement of practical magnesium ion batteries (MIBs). Here, a superior aqueous electrolyte combining with a copper foam interlayer ...
Electronic Modulation of Semimetallic Electrode for 2D van der Waals Devices
(Wiley Periodicals, Inc., 2023-05)
Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases
(Wiley Periodicals, Inc., 2023-05-08)
In the biosynthesis of the tryptophan-linked dimeric diketopiperazines (DKPs), cytochromes P450 selectively couple DKP monomers to generate a variety of intricate and isomeric frameworks. To determine the molecular basis ...