Now showing items 1-10 of 1274
High levels of non-activated receptors in glucocorticoid-sensitive S49wt mouse lymphoma cells incubated with dexamethasone
(Elsevier, 1994-10)
Upon agonist binding the heteromeric glucocorticoid receptor complex under goes a conformational change (receptor activation). This event involves the dissociation of a dimer of 90 kDa heat shock proteins. Whereas receptor ...
Relationship between the subunit structure of insulin receptor and its competence to bind insulin and undergo phosphorylation
(Elsevier, 1984-11-01)
Insulin receptor partially purified from human placenta by chromatography on immobilized wheat germ agglutinin was subjected to affinity cross linking to determine the relationship between the subunit structure of the ...
Leukotriene C4 induces vasogenic cerebral edema in rats
(Elsevier, 1984-06)
Leukotriene C4 (LTC4) is reported to neither contract nor relax isolated human cerebra artdial strips (1), but in skin LTC4 will increase vascular permeability in post capillary venules, increase blood flow (2) and elicit ...
Hormonal regulation of plasminogen activator in rat hepatoma cells
(Kluwer Academic Publishers; Martinus Nijhoff Publishers ; Springer Science+Business Media, 1983-03)
Plasminogen activators are membrane-associated, arginine-specific serine proteases which convert the inactive plasma zymogen plasminogen to plasmin, an active, broad-spectrum serine protease. Plasmin, the major fibrinolytic ...
Characterization of gastrin amidation in the rat and porcine antrum: comparison with the pituitary
(Elsevier, 1990-04-24)
The formation of biologically active gastrin from glycine-extended processing intermediates occurs via the action of a peptide [alpha]-amidating enzyme. The observation that gastrin exists primarily as unamidated precursors ...
The specificity and significance of the inhibition of Fc receptor binding by anti H-2 sera
(Springer-Verlag; Springer-Verlag New York Inc., 1975-12)
The possibility that Ia antigens are unique among H-2 antigens in their relationship to the Fc receptor was investigated in an EA rosette assay. Antibody specific for antigens in various regions of the H-2 complex was ...
Suppression of natural killer (NK) cell activity of spleen cells by thymocytes
(Elsevier, 1981-02)
The in vitro influence of thymus cells on natural killer cell activity of spleen cells against prelabeled target cells (YAC-I and RL[male symbol]I) has been studied in syngeneic as well as in allogeneic murine models. In ...