SUPPRESSION OF SYMPATHETIC NERVOUS FUNCTION IN LOW-RENIN ESSENTIAL HYPERTENSION
dc.contributor.author | Esler, Murray D. | en_US |
dc.contributor.author | Randall, Otelio S. | en_US |
dc.contributor.author | Bennett, J. | en_US |
dc.contributor.author | Zweifler, Andrew J. | en_US |
dc.contributor.author | Julius, Stevo | en_US |
dc.contributor.author | Rydelek, P. | en_US |
dc.contributor.author | Cohen, Edwin L. | en_US |
dc.contributor.author | Dequattro, V. | en_US |
dc.date.accessioned | 2006-04-07T16:27:12Z | |
dc.date.available | 2006-04-07T16:27:12Z | |
dc.date.issued | 1976-07-17 | en_US |
dc.identifier.citation | Esler, M., Randall, O., Bennett, J., Zweifler, A., Julius, S., Rydelek, P., Cohen, E., Dequattro, V. (1976/07/17)."SUPPRESSION OF SYMPATHETIC NERVOUS FUNCTION IN LOW-RENIN ESSENTIAL HYPERTENSION." The Lancet 308(7977): 115-118. <http://hdl.handle.net/2027.42/21720> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1B-49MMTD9-T6/2/a2003c0c09f8787ca86e0ca71e5dea56 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/21720 | |
dc.description.abstract | Study of general haemodynamics in 15 patients with low-renin essential hypertension showed haemodynamic and pathophysiological heterogeneity. However, there was suppression of sympathetic nervous system function in all low-renin patients, regardless of haemodynamic pattern. Subnormal sympathetic nervous activity was manifested by a low normal mean plasma-noradrenaline concentration at rest, diminished noradrenaline responsiveness to postural stimulation, and a reduced blood-pressure response to the indirectly acting sympathomimetic amine tyramine. It is proposed that the syndrome of low-renin essential hypertension is of diverse aetiology, but with secondary sympathetic nervous system underactivity as a feature common to the various forms. The low plasmarenin activity is probably an expression of defective sympathetic nervous system stimulation of renin release. | en_US |
dc.format.extent | 461916 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | SUPPRESSION OF SYMPATHETIC NERVOUS FUNCTION IN LOW-RENIN ESSENTIAL HYPERTENSION | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Hypertension Section, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.. | en_US |
dc.contributor.affiliationum | Hypertension Section, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.. | en_US |
dc.contributor.affiliationum | Hypertension Section, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.. | en_US |
dc.contributor.affiliationum | Hypertension Section, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.. | en_US |
dc.contributor.affiliationum | Hypertension Section, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.. | en_US |
dc.contributor.affiliationum | Hypertension Section, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.. | en_US |
dc.contributor.affiliationum | Section of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor, United States | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Southern California Medical Center, Los Angeles, California, United States | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/21720/1/0000112.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0140-6736(76)92844-0 | en_US |
dc.identifier.source | The Lancet | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.