Synthesis of potential antiprogestogens

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dc.contributor.author Beyer, Bernardo en_US
dc.contributor.author Terenius, Lars en_US
dc.contributor.author Brueggemeier, Robert W. en_US
dc.contributor.author Ranade, Vasant V. en_US
dc.contributor.author Counsell, Raymond E. en_US
dc.date.accessioned 2006-04-07T16:32:03Z
dc.date.available 2006-04-07T16:32:03Z
dc.date.issued 1976-01 en_US
dc.identifier.citation Beyer, Bernardo, Terenius, Lars, Brueggemeier, Robert W., Ranade, Vasant V., Counsell, Raymond E. (1976/01)."Synthesis of potential antiprogestogens." Steroids 27(1): 123-131. <http://hdl.handle.net/2027.42/21879> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6TC9-47NVJT1-BD/2/5396a79cbda853c5add9ba39df0b72bf en_US
dc.identifier.uri http://hdl.handle.net/2027.42/21879
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=178072&dopt=citation en_US
dc.description.abstract Acylated derivatives of 17[alpha]-hydroxyprogesterone were prepared in order to test the hypothesis that dialkylamino alkyl moieties have the effect of transforming progestogens into antiprogestogens. This approach has been successful with certain estrogens. Compounds with other functional groups were synthesized to determine whether these might exert binding influence outside the area occupied by progesterone itself. The compounds were tested for competitive affinity against tritiated progesterone and receptor from rabbit uterus cytosol. The low affinity of all derivatives makes it unlikely that they would be active as antiprogestational agents. en_US
dc.format.extent 427315 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title Synthesis of potential antiprogestogens en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Public Health en_US
dc.subject.hlbsecondlevel Chemistry en_US
dc.subject.hlbsecondlevel Chemical Engineering en_US
dc.subject.hlbsecondlevel Biological Chemistry en_US
dc.subject.hlbtoplevel Engineering en_US
dc.subject.hlbtoplevel Science en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Medical Pharmacology, University of Uppsala, Uppsala, Sweden; Laboratory of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.; en_US
dc.contributor.affiliationum Department of Medical Pharmacology, University of Uppsala, Uppsala, Sweden; Laboratory of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.; en_US
dc.contributor.affiliationum Department of Medical Pharmacology, University of Uppsala, Uppsala, Sweden; Laboratory of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.; en_US
dc.contributor.affiliationum Department of Medical Pharmacology, University of Uppsala, Uppsala, Sweden; Laboratory of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.; en_US
dc.contributor.affiliationum Laboratory of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.; Department of Medical Pharmacology, University of Uppsala, Uppsala, Sweden en_US
dc.identifier.pmid 178072 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/21879/1/0000285.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0039-128X(76)90073-8 en_US
dc.identifier.source Steroids en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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