Autonomic nervous cardiovascular regulation in borderline hypertension
dc.contributor.author | Julius, Stevo | en_US |
dc.contributor.author | Esler, Murray D. | en_US |
dc.date.accessioned | 2006-04-07T16:34:50Z | |
dc.date.available | 2006-04-07T16:34:50Z | |
dc.date.issued | 1975-10-31 | en_US |
dc.identifier.citation | Julius, Stevo, Esler, Murray (1975/10/31)."Autonomic nervous cardiovascular regulation in borderline hypertension." The American Journal of Cardiology 36(5): 685-696. <http://hdl.handle.net/2027.42/21968> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T10-4BW0S05-1RN/2/c8f37754e8047259f291449af4cbf57d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/21968 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=171939&dopt=citation | en_US |
dc.description.abstract | Borderline hypertension attracts investigative interest since it is an early predictor of established hypertension and its sequelae. This condition offers the opportunity of studying arterial hypertension at its inception, before the development of secondary pressure-related changes. A number of abnormalities of the circulation have been described in borderline hypertension. The peripheral resistance is either elevated or inappropriately adjusted to the prevailing increased cardiac output and blood flow. Cardiac output, heart rate and stroke volume are elevated in a proportion of patients. Decreased plasma volume, enhanced pressor responsiveness and elevated plasma renin activity have also been noted. All these changes could hypothetically be explained by a neurogenic mechanism. Although the experimental evidence supporting a neurogenic origin of borderline hypertension is incomplete and often indirect, most findings point toward an abnormal autonomic control of the circulation in this disorder.It is postulated that in a subgroup of patients with borderline hypertension a neurogenic mechanism is in fact operative. There is a need for further characterization of this category of borderline hypertension and for description of its natural history, particularly in relation to the possible subsequent development of essential hypertension. | en_US |
dc.format.extent | 1658659 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Autonomic nervous cardiovascular regulation in borderline hypertension | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | From The Hypertension Section, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | From The Hypertension Section, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA | en_US |
dc.identifier.pmid | 171939 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/21968/1/0000377.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-9149(75)90170-8 | en_US |
dc.identifier.source | The American Journal of Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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