Effect of phentolamine on platelet aggregation in patients with pheochromocytoma
dc.contributor.author | Zweifler, Andrew J. | en_US |
dc.contributor.author | Romero, Sylvia | en_US |
dc.date.accessioned | 2006-04-07T16:35:18Z | |
dc.date.available | 2006-04-07T16:35:18Z | |
dc.date.issued | 1975-10 | en_US |
dc.identifier.citation | Zweifler, Andrew J., Romero, Sylvia (1975/10)."Effect of phentolamine on platelet aggregation in patients with pheochromocytoma." Thrombosis Research 7(4): 505-513. <http://hdl.handle.net/2027.42/21983> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1C-4C00HBB-GM/2/a0da3dfb14f52f68b57ab2d3e1913601 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/21983 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1198544&dopt=citation | en_US |
dc.description.abstract | Since exogeneous catecholamines potentiate ADP-induced aggregation in vitro, and this effect is blocked directly by phentolamine, it was assumed that platelets from patients with pheochromocytoma would be unusually sensitive to ADP and that this sensitivity would be reduced in the presence of phentolamine. Findings in four patients with pheochromocytoma were compared to results in 20 normals. Phentolamine had no immediate effect in either group. Pheochromocytoma platelets became more responsive to ADP after standing and this increase in responsiveness was inhibited by phentolamine. These results: 1) suggest that catecholamine concentrations in the plasma of patients with pheochromocytoma are not high enough to potentiate ADP aggregation and 2) may be explained by assuming that pheochromocytoma platelets are saturated with catecholamines. | en_US |
dc.format.extent | 593607 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effect of phentolamine on platelet aggregation in patients with pheochromocytoma | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine Hypertension Section University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine Hypertension Section University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 1198544 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/21983/1/0000393.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0049-3848(75)90098-5 | en_US |
dc.identifier.source | Thrombosis Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.