Evidence for an activating factor formed during prostaglandin biosynthesis
dc.contributor.author | Cook, Harold W. | en_US |
dc.contributor.author | Lands, William E. M. | en_US |
dc.date.accessioned | 2006-04-07T16:36:29Z | |
dc.date.available | 2006-04-07T16:36:29Z | |
dc.date.issued | 1975-07-22 | en_US |
dc.identifier.citation | Cook, Harold W., Lands, William E.M. (1975/07/22)."Evidence for an activating factor formed during prostaglandin biosynthesis." Biochemical and Biophysical Research Communications 65(2): 464-471. <http://hdl.handle.net/2027.42/22023> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4G3D5KD-6S/2/f0b286a24eb96c79abedf95911bfbbb9 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22023 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1148003&dopt=citation | en_US |
dc.description.abstract | SummaryThe oxygenation of 5,8,11,14-eicosatetraenoic acid by acetone powder preparations of sheep vesicular glands proceeded with a lag or accelerative phase when inhibitory concentrations of NaCN were present. This accelerative feature of the reaction suggested that an activating material might be produced as the oxygenation reaction proceeds. When a second addition of fresh enzyme was made to a reaction mixture, the lag phase was as short as in uninhibited controls. This indicated that an activating factor was required for optimal activity of this dioxygenase, and that it accumulated during the oxygenation reaction in the presence of NaCN. The factor was extracted from an aqueous incubation medium with cold diethyl ether. There was a positive relationship between the amount of activating factor added and the resultant increase in the initial velocity of the oxygenation system. | en_US |
dc.format.extent | 375610 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Evidence for an activating factor formed during prostaglandin biosynthesis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry The University of Michigan Ann Arbor, Michigan 48104, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry The University of Michigan Ann Arbor, Michigan 48104, USA | en_US |
dc.identifier.pmid | 1148003 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22023/1/0000439.pdf | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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